ACE‐mediated Glycosylation Stabilizes PSAP To Promote GPR37‐dependent Macrophage‐Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration [PDF]
Advanced ScienceIntervertebral disc degeneration (IDD) represents a complex pathological process involving impaired cellular homeostasis and extracellular matrix dysregulation.
Youfeng Guo +6 more
doaj +3 more sources
GPR37 and its neuroprotective mechanisms: bridging osteocalcin signaling and brain function [PDF]
Frontiers in Cell and Developmental BiologyOsteocalcin (OCN) is a hormone secreted by osteoblasts and has attracted widespread attention for its role in regulating brain function. Clinical studies indicate a positive correlation between levels of circulating OCN and cognitive performance. Indeed,
Xuepeng Bian +4 more
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GPR37 promotes the malignancy of lung adenocarcinoma via TGF-β/Smad pathway
Open Medicine (Poland), 2020 This paper aimed to research the function and in-depth mechanism of GPR37 in lung adenocarcinoma (LUAD). Herein, based on TCGA and Oncomine databases, we revealed that GPR37 was expressed at high levels in LUAD, and upregulation of GPR37 was related to ...
Wang Jian +4 more
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Pharmacological Research, 2022 Lung adenocarcinoma (LUAD) is associated with poor prognosis. Identifying novel cancer targets and helpful therapeutic strategies remains a serious clinical challenge.
Xiaona Xie, Luqiong Cai, Yaozhe Li
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GPR37 modulates body weight and insulin sensitivity in a sex-biased manner. [PDF]
PLoS ONEMetabolic disorders are a growing public health concern in the United States, with approximately 40% of the population living with obesity. The urgent need for novel therapeutic targets has driven interest in G protein-coupled receptors (GPCRs), a ...
Mariam Ahmed +6 more
doaj +2 more sources
Neuroprotectin D1 and GPR37 protect against chemotherapy-induced peripheral neuropathy and the transition from acute to chronic pain [PDF]
Pharmacological ResearchChemotherapy-induced peripheral neuropathy (CIPN) significantly impacts patient’s quality of life and complicates cancer treatment. Neuroprotectin D1 (NPD1)/protectin D1 (PD1), derived from docosahexaenoic acid (DHA), exhibits analgesic actions in animal
Jing Xu +6 more
doaj +2 more sources
Biomedicines, 2022 The G protein-coupled receptor 37 (GPR37) has been reported to be expressed in macrophages and the activation of GPR37 by its ligand/agonist, and it can regulate macrophage-associated functions and inflammatory responses.
Haiyang Yang, Yanjiao Li
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Oligodendrocyte prosaposin restores subarachnoid haemorrhage-induced consciousness impairment [PDF]
Experimental and Molecular MedicineSubarachnoid haemorrhage (SAH) is a life-threatening cerebrovascular event frequently accompanied by consciousness disturbances, yet the underlying mechanisms remain poorly defined.
Haiying Li +10 more
doaj +2 more sources
Role and regulatory mechanism of GPR37 in neurological diseases [PDF]
Frontiers in Cellular NeuroscienceG protein-coupled receptor 37 is an orphan Class A GPCR predominantly expressed in the central nervous system (CNS), implicated in diverse physiological and pathological processes.
Shuo Liu +7 more
doaj +2 more sources
Lactylation-related gene signature for prognosis prediction and immune infiltration assessment in lung adenocarcinoma via bulk and single-cell RNA sequencing [PDF]
Discover OncologyLung cancer remains the leading cause of cancer incidence and mortality globally, yet its molecular mechanisms remain poorly understood. Recent studies highlight the role of protein lactylation in regulating tumor microenvironment (TME) dynamics, tumor ...
Hua Zhou +3 more
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