Results 41 to 50 of about 1,699 (149)
PLoS ONE, 2021 Prosaposin (PSAP), a highly conserved glycoprotein, is a precursor of saposins A–D. Accumulating evidence suggests that PSAP is a neurotrophic factor, as well as a regulator of lysosomal enzymes. Recently, the orphan G-protein-coupled receptors GPR37 and
Miho Taniguchi +10 more
doaj +2 more sources
Macroautophagy of the GPR37 orphan receptor and Parkinson disease-associated neurodegeneration [PDF]
Autophagy, 2009 Parkinson disease (PD) is among the most common human neurodegenerative diseases and it is characterized by progressive degeneration of dopaminergic neurons in the substantia nigra (SN), with concomitant accumulation of typical cytoplasmic inclusions called Lewy bodies (LB).
Daniela Marazziti +5 more
openaire +4 more sources
Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37 [PDF]
Journal of Clinical Investigation, 2018 Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an ...
Lintao, Qu, Michael J, Caterina
openaire +2 more sources
Mutation in Parkinson disease-associated, G-protein-coupled receptor 37 (GPR37/PaelR) is related to autism spectrum disorder. [PDF]
PLoS ONE, 2012 Little is known about the molecular pathogenesis of Autism spectrum disorder (ASD), a neurodevelopmental disorder. Here we identified two mutations in the G-protein-coupled receptor 37 gene (GPR37) localized on chromosome 7q31-33, called the AUTS1 region,
Eriko Fujita-Jimbo +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2019 Gonadotropin releasing hormone (GnRH) neurons, part of the hypothalamic-pituitary-gonadal axis, regulate reproduction. Prenatally, GnRH neurons migrate into the brain from the nasal placode along terminal nerve fibers, intermixed with olfactory sensory ...
Hassan Saadi +3 more
doaj +1 more source
Cytosolic GPR37, but not GPR37L1, multimerization and its reversal by Parkin: A live cell imaging study [PDF]
The FASEB Journal, 2021 Abstract Biochemical data have shown aggregated G protein‐coupled receptor 37 (GPR37) in the cytoplasm and Lewy bodies in Parkinson's disease (PD). Properly folded GPR37 at the plasma membrane appears to be neuroprotective. GPR37, and its homologue GPR37L1, are orphan G protein‐coupled receptors and their homo‐ and hetero‐dimers have ...
Li, Tianyi +5 more
openaire +3 more sources
Frontiers in Pharmacology, 2015 Orphan G protein-coupled receptors (GPCRs) represent a largely untapped resource for the treatment of a variety of diseases, despite sophisticated advances in drug discovery.
Nicola J Smith, Nicola J Smith
doaj +1 more source
Mouse Mutants of Gpr37 and Gpr37l1 Receptor Genes: Disease Modeling Applications
International Journal of Molecular Sciences, 2022 The vertebrate G protein–coupled receptor 37 and G protein–coupled receptor 37-like 1 (GPR37 and GPR37L1) proteins have amino acid sequence homology to endothelin and bombesin-specific receptors. The prosaposin glycoprotein, its derived peptides, and analogues have been reported to interact with and activate both putative receptors.
Marzia Massimi +3 more
openaire +3 more sources
G protein‐coupled receptor GPR37‐like 1 regulates adult oligodendrocyte generation [PDF]
Developmental Neurobiology, 2021 AbstractOligodendrocytes (OLs) continue to be generated from OL precursors (OPs) in the adult mammalian brain. Adult‐born OLs are believed to contribute to neural plasticity, learning and memory through a process of “adaptive myelination,” but how adult OL generation and adaptive myelination are regulated remains unclear.
Jing An +5 more
openaire +3 more sources
Glia, Volume 74, Issue 11, November 2026.Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis +10 more
wiley +1 more source