Results 21 to 30 of about 1,699 (149)

Lipid‐Based Modulation of Neurogenesis: DHA‐H and HPA Promote Proliferation and Differentiation in Alzheimer's Models [PDF]

Alzheimers Dement
Abstract Background Lipids are fundamental to neuronal function, and disruptions in lipid homeostasis are increasingly recognized as key contributors to neurodegenerative diseases such as Alzheimer's disesase. While lipid dysregulation is known to alter protein function, the therapeutic potential of lipid‐based interventions remains largely unexplored.
Castroflorio E, Cabot J, Suau M, Fernández‐García P, Lladó V, Escriba P, Torres M.   +6 more
europepmc   +2 more sources

NAT10 contributes to the progression of multiple myeloma through ac4C modification of GPR37

Hematology
Background: Multiple myeloma (MM) is a malignant plasma-cell disease. Epigenetic modifications, including acetylation, are thought to contribute to tumorigenesis.
Haiyan Liu, Xiuxiu Zhang, Qin Lu, Hui Zhang   +3 more
doaj   +3 more sources

Mitochondrial DNA methylation predicts immunotherapy response and prognosis in lung adenocarcinoma: evidence from scRNA-Seq and machine learning [PDF]

BMC Cancer
Background Lung adenocarcinoma (LUAD) represents an aggressive malignancy characterized by high metastatic potential. Emerging evidence suggests mitochondrial DNA methylation (MTDM) plays a pivotal role in regulating gene expression through protein ...
Jian Ding, Gang Cheng, Qian Xue, Weizhen Guo, Yikun Cheng, Cheng Yang, Jiabing Tong, Zegeng Li, Yating Gao   +8 more
doaj   +2 more sources

Prosaposin orchestrates a TGFβ1-driven paracrine loop between Schwann cells and gastric cancer to accelerate perineural invasion [PDF]

Journal of Experimental & Clinical Cancer Research
Perineural invasion (PNI) is an established adverse prognostic factor in gastric cancer (GC), yet the molecular events initiating this process remain poorly defined.
Shijie Yang, Huan Xi, Miao Yu, LinFan Qi, Lin Ma, ZiJian Wu, Guangming Zhang, Shixun Ma, Hui Cai   +8 more
doaj   +2 more sources

Identification and validation of lung adenocarcinoma (LUAD)-associated targets for monascin from the extracts of Monascus purpureus-fermented rice: Compound preparation, high-throughput genome sequencing and bioinformatics analysis [PDF]

Saudi Pharmaceutical Journal
Despite the remarkable bioactivities exhibited by monascin against several tumors, its therapeutic targets remain unexplored. In this study, our objective is to identify therapeutic targets based on the antitumor activity of monascin against lung ...
Xilinqiqige Bao, Hanqing Li, Jiayin Xu, Xiaoqing Liu, Runa A, Jianming Chen, Fengzheng Chen, Nan Ya, Rigula Sa   +8 more
doaj   +2 more sources

Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression [PDF]

Scientific Reports
Osteocalcin (OCN) is an endocrine hormone that signals in the periphery, regulating male fertility, energy expenditure and glucose homeostasis. It can also cross the blood-brain-barrier and act on the brain via receptors GPR37 and GPR158.
Natalia K. Freus, Isabel Wank, Maximilian Häfele, Liubov S. Kalinichenko, Christian P. Müller, Sandra Strobelt, Andreas Ludwig, Andreas Hess, Silke Kreitz   +8 more
doaj   +2 more sources

GPR37 is processed in the N‐terminal ectodomain by ADAM10 and furin [PDF]

The FASEB Journal, 2021
Abstract GPR37 is an orphan G protein‐coupled receptor (GPCR) implicated in several neurological diseases and important physiological pathways in the brain. We previously reported that its long N‐terminal ectodomain undergoes constitutive metalloprotease‐mediated cleavage and shedding, which have been rarely described for class A ...
Mattila, S. Orvokki, Tuhkanen, Hanna E., Lackman, Jarkko J., Konzack, Anja, Morató Arús, Xavier, Argerich, Josep, Saftig, Paul, Ciruela Alférez, Francisco, Petäjä-Repo, Ulla E.   +8 more
openaire   +4 more sources

Prognostic, chemotherapy and immunotherapy roles of GPR37/GPR37L1 in pan-cancer. [PDF]

Medicine (Baltimore)
G protein-coupled receptor 37 ( GPR37 ) and G protein-coupled receptor 37 like 1 ( GPR37L1 ) are implicated in tumorigenesis; however, their prognostic significance and roles in chemotherapy and immunotherapy responses across diverse cancers is ...
Zhu G, He J, Shi N, Cai Z, Zhang J, Wang SCY, Li J, Zhang M, Wang Y.   +8 more
europepmc   +3 more sources

GzESTY as an optimized cell-based assay for initial steps in GPCR deorphanization [PDF]

Nature Communications
G protein-coupled receptors (GPCRs) are key pharmacological targets, yet many remain underutilized due to unknown activation mechanisms and ligands. Orphan GPCRs, lacking identified natural ligands, are a high priority for research, as identifying their ...
Luca Franchini, Joseph J. Porter, John D. Lueck, Cesare Orlandi   +3 more
doaj   +2 more sources

GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling [PDF]

International Journal of Molecular Sciences, 2021
G-protein-coupled receptors (GPCRs) are commonly pharmacologically modulated due to their ability to translate extracellular events to intracellular changes. Previously, studies have mostly focused on protein–protein interactions, but the focus has now expanded also to protein–lipid connections.
Hertz, Ellen, Saarinen, Marcus, Svenningsson, Per   +2 more
openaire   +2 more sources