GPR37 processing in neurodegeneration: a potential marker for Parkinson’s Disease progression rate [PDF]
npj Parkinson's DiseaseThe orphan G protein-coupled receptor 37 (GPR37), widely associated with Parkinson’s disease (PD), undergoes proteolytic processing under physiological conditions.
Josep Argerich +11 more
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Ecto-GPR37: a potential biomarker for Parkinson’s disease [PDF]
Translational Neurodegeneration, 2021 Objective α-Synuclein has been studied as a potential biomarker for Parkinson’s disease (PD) with no concluding results. Accordingly, there is an urgent need to find out reliable specific biomarkers for PD.
Xavier Morató +12 more
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Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics [PDF]
Frontiers in Molecular Neuroscience, 2018 Despite the progress in deorphanization of G Protein-Coupled Receptors (GPCRs), ≈100 GPCRs are still classified as orphan receptors without identified endogenous ligands and with unknown physiological functions.
Wu Zheng +20 more
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Protectin DX resolves fracture-induced postoperative pain in mice via neuronal signaling and GPR37-activated macrophage efferocytosis [PDF]
The Journal of Clinical InvestigationProtectin DX (PDX) is a member of the superfamily of specialized proresolving mediators and exerts anti-inflammatory actions in animal models; however, its signaling mechanism remains unclear.
Yize Li +7 more
doaj +2 more sources
GPR37-enhanced ubiquitination of ATP1A1 inhibits tumor progression and radiation resistance in esophageal squamous cell carcinoma [PDF]
Cell Death and DiseaseRadiotherapy resistance is one of the main reasons for the dismal clinical outcome of patients with esophageal squamous cell carcinoma (ESCC). Therefore, clarifying the targets and molecular mechanisms of radiotherapy resistance in ESCC is of great ...
Jiaru Hu +10 more
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Gpr37 modulates the severity of inflammation-induced GI dysmotility by regulating enteric reactive gliosis [PDF]
iScienceSummary: The enteric nervous system (ENS) is contained within two layers of the gut wall and is made up of neurons and enteric glial cells (EGCs) that regulate gastrointestinal (GI) function.
Keiramarie Robertson +13 more
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Cell ReportsSummary: Parkinson’s disease (PD) is a common neurodegenerative disease and is difficult to treat due to its elusive mechanisms. Recent studies have identified a striking association between oligodendrocytes and PD progression, yet how oligodendrocytes ...
Zhen‐Zhong Xu
exaly +3 more sources
GPR37 Activation Alleviates Bone Cancer Pain via the Inhibition of Osteoclastogenesis and Neuronal Hyperexcitability [PDF]
Advanced ScienceOsteolytic bone cancer pain is a primary concern for cancer patients with bone metastasis, and current therapies offer inadequate pain relief. The present study demonstrates that activation of the G protein‐coupled receptor 37 (GPR37) by neuroprotectin ...
Kaiyuan Wang +10 more
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LTCONS_00014107-miR-29b-2-3p-GPR37 axis promotes heat stimulation induced esophageal carcinogenesis [PDF]
Cancer Cell InternationalEsophageal cancer is a common malignant tumor of the digestive system, and Esophageal squamous cell carcinoma (ESCC) is the major histological subtype of esophageal cancer.
Wenting Liu +11 more
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From Hydra to Humans: Head Activator in Neurogenesis and Neurorepair [PDF]
CellsHydra vulgaris, an ancient cnidarian, exhibits remarkable regenerative and neurogenic abilities, mediated by morphogenetic peptides, particularly the head activator peptide.
Andrii Klymenko, David Lutz
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