Results 51 to 60 of about 1,699 (149)

REG4 promotes peritoneal metastasis of gastric cancer through GPR37

Oncotarget, 2016
Being the major reason of recurrence and death after surgery, peritoneal metastasis of gastric cancer dooms the prognosis of advanced gastric cancer patients. Regenerating islet-derived family, member 4 (REG4) is believed to promote peritoneal metastasis, however, its mechanism is still a moot point at present.
Wang, Hexiao, Hu, Lei, Zang, Mingde, Zhang, Baogui, Duan, Yantao, Fan, Zhiyuan, Li, Jianfang, Su, Liping, Yan, Min, Zhu, Zhenggang, Liu, Bingya, Yang, Qiumeng   +11 more
openaire   +3 more sources

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling

Cell Reports, 2023
Summary: Macrophages release soluble mediators following efferocytic clearance of apoptotic cells to facilitate intercellular communication and promote the resolution of inflammation. However, whether inflammation resolution is modulated by extracellular
Purbasha Bhattacharya, Umesh Kumar Dhawan, Mohammed Tayab Hussain, Praveen Singh, Karran Kiran Bhagat, Aarushi Singhal, Shani Austin-Williams, Shantanu Sengupta, Manikandan Subramanian   +8 more
doaj   +1 more source

Predicting Relevant Microglia‐Associated Cell–Cell Communication Pathways in Alzheimer's Disease: A Role for SPP1

Glia, Volume 74, Issue 10, October 2026.
We used CellChat to infer altered cell–cell communication in Alzheimer's disease Microglia signal to each other via SPP1 in Alzheimer's disease. SPP1‐expressing microglia are present around amyloid‐β plaques. ABSTRACT Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease ...
Janssen M. Kotah, Marina Trombetta Lima, Esmée C. Dragt, Asimenia Voulgaroglou, Nieske Brouwer, Inge R. Holtman, Susanne M. Kooistra, Bart J. L. Eggen   +7 more
wiley   +1 more source

Protectin D1 alleviates cardiac ischemia-reperfusion injury in rats by up-regulating GPR37/JNK/PPAR-γ signaling pathway in cardiac macrophages

Di-san junyi daxue xuebao, 2019
Objective To investigate the mechanism by which protectin D1 (PD1) alleviates cardiac ischemia-reperfusion (IR) injury via GPR37/JNK/PPAR-γ signaling pathway.
ZENG Yalin, ZHOU Qin, XIONG Qingsong, CHEN Yunqing   +3 more
doaj   +1 more source

An epigenome-wide analysis of socioeconomic position and tumor DNA methylation in breast cancer patients

Clinical Epigenetics, 2023
Background Disadvantaged socioeconomic position (SEP), including lower educational attainment and household income, may influence cancer risk and outcomes.
Jianhong Chen, Mark D. Long, Sirinapa Sribenja, Sung Jun Ma, Li Yan, Qiang Hu, Song Liu, Thaer Khoury, Chi-Chen Hong, Elisa Bandera, Anurag K. Singh, Elizabeth A. Repasky, Elizabeth G. Bouchard, Michael Higgins, Christine B. Ambrosone, Song Yao   +15 more
doaj   +1 more source

Cancer‐related pain: A bidirectional modulator of cancer progression

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He, Yu Zhang, Qian Liu, Biao Yan, Peiwei Chai, Renbing Jia   +5 more
wiley   +1 more source

GPR37-centered ceRNA network contributes to metastatic potential in lung adenocarcinoma: Evidence from high-throughput sequencing

Translational Oncology
The competing endogenous RNA (ceRNA)-based profiling has been extensively studied in carcinogenesis of lung adenocarcinoma (LUAD), while it has seldomly been applied to investigate the metastatic potential of LUAD. This study aims to examine the function
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu   +4 more
doaj   +1 more source

Comprehensive analysis of competitive endogenous RNA associated with immune infiltration in lung adenocarcinoma

Scientific Reports, 2021
To identify the prognostic biomarker of the competitive endogenous RNA (ceRNA) and explore the tumor infiltrating immune cells (TIICs) which might be the potential prognostic factors in lung adenocarcinoma.
Wenjie Chen, Wen Li, Zhenkun Liu, Guangzhi Ma, Yunfu Deng, Xiaogang Li, Zhu Wang, Qinghua zhou   +7 more
doaj   +1 more source

Metabolism in Tumor: Mechanisms and Therapeutic Perspectives

MedComm, Volume 7, Issue 9, September 2026.
Tumor metabolic reprogramming converges on three hubs—the SREBP1/2–FASN–SCD1 lipogenic axis, the HIF‐1α–GLUT1–LDHA glycolytic axis, and the LDLR–SCARB1–LXR cholesterol system—which integrate transcriptional, epigenetic (histone lactylation, m6A), and microenvironmental inputs to generate metabolic plasticity, immune evasion, and therapy resistance ...
Jia‐Chen Cheng, Yi‐Xuan Hu, Xiang‐Chun Huang, Shan Jiang, Jie‐Lin Wang, Yang Zhao, Shuo Chen   +6 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source