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Rapid detection of Seneca Valley virus based on reverse transcription recombinase polymerase amplification and CRISPR-Cas13a. [PDF]

open access: yesVirulence
Wu Y   +13 more
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Recombinant pseudorabies virus (PRV) expressing stabilized E2 of classical swine fever virus (CSFV) protects against both PRV and CSFV

Antiviral Research, 2023
Pseudorabies (PR) and classical swine fever (CSF) are economically important infectious diseases of pigs. Most pig farms in China are immunized against these two diseases. Here, we describe a stabilized E2 protein as an immunogen inserted into the PRV genome as a bivalent live virus-vectored vaccine.
Yang-yang Sun   +12 more
openaire   +2 more sources

Vaccines against pseudorabies virus (PrV)

Veterinary Microbiology, 2017
Aujeszkýs disease (AD, pseudorabies) is a notifiable herpesvirus infection of pigs causing substantial economic losses to swine producers. AD in pigs is controlled by the use of vaccination with inactivated and attenuated live vaccines. Starting with classically attenuated live vaccines derived from low virulent field isolates, AD vaccination has ...
C M, Freuling   +2 more
openaire   +2 more sources

The estrous cycle affects pseudorabies virus (PRV) infection of the CNS

Brain Research, 2001
Previous work had suggested that mucosal immunity may be affected by the stage of the estrous cycle. Here, susceptibility to a neurotropic virus infection at different stages of the estrous cycle was assessed in a rodent model after direct injection of the virus into visceral organs.
M L, Weiss   +6 more
openaire   +2 more sources

Degradation of cyclins D in pseudorabies virus (PRV) infected proliferating cells

Veterinary Microbiology, 2006
The pseudorabies virus code for an ICP0 protein which is half the size of the HSV1 ICP0 protein. In this work, we made the assumption that some function might have been lost in the ICP0 from PRV. One function attributed to the ICP0 from HSV1 was the stabilization of cyclins D.
Yannick, Blanchard   +4 more
openaire   +2 more sources

A live gI/gE-deleted pseudorabies virus (PRV) protects weaned piglets against lethal variant PRV challenge

Virus Genes, 2017
Emerging pseudorabies virus (PRV) variant has led to frequent outbreaks of PRV infection among Bartha-K61-vaccinated swine population in Chinese swine farms and caused high mortality in pigs of all age since late 2011. Here, we generated a gE/gI-deleted PRV (rPRVXJ-delgI/gE-EGFP) based on PRV variant strain (PRV-XJ) through homologous DNA recombination.
Yue, Yin   +8 more
openaire   +2 more sources

Effective cross-protection of a lyophilized live gE/gI/TK-deleted pseudorabies virus (PRV) vaccine against classical and variant PRV challenges

Veterinary Microbiology, 2022
Classical Bartha-K61 strains could not provide complete protection against the emerging highly virulent pseudorabies virus (PRV) variant strains, which has caused great economic losses to swine industry in China. In this study, a gE/gI/TK-deleted PRV vaccine strain based on a circulating PRV variant strain HeB12 was generated by serial passages in Vero
Yuzhang, Sun, Ling, Zhao, Zhen F, Fu
openaire   +2 more sources

Molecular epidemiology of outbreak-associated pseudorabies virus (PRV) strains in central China

Virus Genes, 2015
In several parts of China, there have been a large number of pseudorabies (PR) outbreaks which have devastated many swine farms even though the herds had been previously immunized with gE-deleted vaccines (Bartha-K61). The emergence of these outbreak-associated PRV strains might indicate that Bartha-K61 vaccine could not provide effective protection ...
Yinbiao, Wang   +11 more
openaire   +2 more sources

Infection of the mammalian nervous system by pseudorabies virus (PRV)

Seminars in Virology, 1994
Abstract Pseudorabies virus (PRV) is an alphaherpesvirus that causes a disease of economic impact in swine. Studies on the molecular biology and pathogenesis of PRV are well advanced. PRV has a striking neurotropism and can establish latent infections in the peripheral and central nervous system.
openaire   +1 more source

New baculovirus recombinants expressing Pseudorabies virus (PRV) glycoproteins protect mice against lethal challenge infection

Vaccine, 2009
The present study demonstrates the protective potential of novel baculovirus recombinants, which express the glycoproteins gB, gC, or gD of Pseudorabies virus (PRV; Alphaherpesvirus of swine) and additionally contain the glycoprotein G of Vesicular Stomatitis Virus (VSV-G) in the virion (Bac-G-PRV).
Agnieszka K, Grabowska   +5 more
openaire   +2 more sources

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