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The products of 5-fluorouridine by the action of the pseudouridine synthase TruB disfavor one mechanism and suggest another. [PDF]
Miracco EJ, Mueller EG.
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Functional and structural impact of target uridine substitutions on the H/ACA ribonucleoprotein particle pseudouridine synthase. [PDF]
Zhou J, Liang B, Liang B, Li H.
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Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase. [PDF]
Li S +5 more
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Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. [PDF]
Ulland TK +6 more
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X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold [PDF]
Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine in structural RNA. The pseudouridine synthase TruD, that modifies U13 in tRNA, belongs to a recently identified and large family of pseudouridine synthases present in all ...
B Martin Hallberg +2 more
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Pseudouridine synthases catalyze the isomerization of uridine to pseudouridine (Psi) in rRNA and tRNA. The pseudouridine synthase RluF from Escherichia coli (E.C.
Sivaraman J +2 more
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The Pseudouridine Synthases: Revisiting a Mechanism That Seemed Settled
Journal of the American Chemical Society, 2004RNA containing 5-fluorouridine, [f 5U]RNA, has been used as a mechanistic probe for the pseudouridine synthases, which convert uridine in RNA to its C-glycoside isomer, pseudouridine. Hydrated products of f 5U were attributed to ester hydrolysis of a covalent complex between an essential aspartic acid residue and f 5U, and the results were construed as
Christopher J, Spedaliere +3 more
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Journal of Molecular Recognition, 1996
E. coli pseudouridine synthase I (PSUI) catalyzes the rearrangement of uridine residues in positions 38, 39 and 40 of tRNA transcripts to pseudouridine. These positions are located in the anticodon stem-loop of the tRNA molecule. Fourteen different E. coli tRNAs are substrates for the enzyme, whereas four other tRNAs which contain uridine in position ...
David A Horne
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E. coli pseudouridine synthase I (PSUI) catalyzes the rearrangement of uridine residues in positions 38, 39 and 40 of tRNA transcripts to pseudouridine. These positions are located in the anticodon stem-loop of the tRNA molecule. Fourteen different E. coli tRNAs are substrates for the enzyme, whereas four other tRNAs which contain uridine in position ...
David A Horne
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