Results 141 to 150 of about 2,211 (199)

Synthesis, hydrolysis and stability of psilocin glucuronide

Forensic Science International, 2014
A two-step synthesis of psilocin glucuronide (PCG), the main metabolite of psilocin, with methyl 2,3,4-tri-O-isobutyryl-1-O-trichloroacetimidoyl-α-d-glucopyranuronate is reported. With the synthesized PCG, hydrolysis conditions in serum and urine were optimized. Escherichia coli proved to be a better enzyme source for β-glucuronidase than Helix pomatia.
Jennifer Schürenkamp, Heidi Pfeiffer, Matthias Lehr   +2 more
exaly   +3 more sources

Detection of psilocin in body fluids

Forensic Science International, 2000
Active compounds of some mushrooms e.g. Psilocybe cubensis, Paneolus subalteatus or Stropharia coronilla, the psychotropic agents psilocybin and psilocin, have hallucinogenic effects. In one case of 'magic mushroom' intake, we had to analyse blood and urine. Psilocin was detected in the urine with REMEDi HS.
H Käferstein
exaly   +3 more sources

Comparison of psilocin with psilocybin, mescaline and LSD-25

Psychopharmacology, 1962
1. Reactions induced by LSD, mescaline, psilocin, and psilocybin are qualitatively similar. 2. The time course of the psilocin and psilocybin reactions are shorter than those of LSD or mescaline reactions. li 4. Psilocin is approximately 1.4 times as potent as psilocybin.
E J Miner, Harris Isbell, Isbell Harris   +2 more
exaly   +3 more sources

Immunochemical monitoring of psilocybin and psilocin to identify hallucinogenic mushrooms

Journal of Pharmaceutical and Biomedical Analysis, 2020
Development of rapid and reliable immunochemical methods for monitoring psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine; Pyb) and psilocin (dephosphorylated metabolite; Psi), the psychoactive compounds contained within hallucinogenic mushrooms (magic mushrooms), is desirable in order to identify these mushrooms and regulate their illicit use ...
Izumi Morita, Hiroyuki Oyama, Jun Ogata   +2 more
exaly   +3 more sources

Development of a psilocin immunoassay for serum and blood samples

International Journal of Legal Medicine, 2004
After the immunisation of rabbits with a psilocin-specific immunogen, polyclonal antisera were obtained. With these antisera a competitive, heterogeneous radioimmunoassay for the detection of psilocin was developed. As tracer a derivative of psilocin was synthesised, which contained a tritiated CH(3) group.
J Beike, Kohler H, Brinkmann B
exaly   +3 more sources

Psilocin suppresses methamphetamine‐induced hyperlocomotion and acquisition of conditioned place preference via D2R‐mediated ERK signaling

CNS Neuroscience and Therapeutics, 2023
Psilocin is an active metabolite form of psilocybin and exerts psychoactive effects. Recent studies suggest that psilocin may have regulatory effects on abuse drugs, but the mechanisms remain unclear.
Qing Shang, Hongyan Qian, Xinshe Liu
exaly   +2 more sources

Psilocin – The “real deal” or an extraction byproduct

Journal of Forensic Sciences, 2022
AbstractMost illicit drug casework samples at the Israel Police National Drug Laboratory are found to be mixtures of substances. Some are a mixture of an illicit drug with fillers, and others may contain more than one illicit drug. This study was triggered by a routine gas chromatography‐mass spectrometry (GC‐MS) analysis of an unusual casework sample.
Ori, Gutman, Dana, Tenne, Uriel, Bretler
openaire   +2 more sources

The fate of psilocin in the rat

Biochemical Pharmacology, 1962
Abstract The synthesis of 14 C-psilocin labelled in two different positions is described. The resorption, distribution, excretion and metabolism of psilocin in the rat was studied quantitatively with the labelled compounds.
F, KALBERER, W, KREIS, J, RUTSCHMANN
openaire   +2 more sources

The Detection of Psilocin in Human Urine

Journal of Forensic Sciences, 2001
Abstract Pharmacokinetic studies of psilocybin in humans have shown the rapid dephosphorylation of psilocybin to psilocin with further conversion to 4-hydroxy-tryptophole (4HT) and 4-hydroxyindole-3-acetic acid (4HIAA) in plasma. Our study shows that psilocin also undergoes conjugation and can be found in the urine as the psilocin ...
A F, Grieshaber, K A, Moore, B, Levine
openaire   +2 more sources

Psilocybin and psilocin regulate microglial immunomodulation and support neuroplasticity via serotonergic and AhR signaling.

International Immunopharmacology
BACKGROUND Psilocybin, a serotonergic psychedelic, has demonstrated therapeutic potential in neuropsychiatric disorders. While its neuroplastic and immunomodulatory effects are recognized, the underlying mechanisms remain unclear. This study investigates
Salma Laabi, Claire LeMmon, Callie Vogel, Mariana Chacon, V. M. Jiménez   +4 more
semanticscholar   +1 more source