Results 161 to 170 of about 2,780 (214)

Synthesis, hydrolysis and stability of psilocin glucuronide

Forensic Science International, 2014
A two-step synthesis of psilocin glucuronide (PCG), the main metabolite of psilocin, with methyl 2,3,4-tri-O-isobutyryl-1-O-trichloroacetimidoyl-α-d-glucopyranuronate is reported. With the synthesized PCG, hydrolysis conditions in serum and urine were optimized. Escherichia coli proved to be a better enzyme source for β-glucuronidase than Helix pomatia.
Jennifer Schürenkamp, Matthias Lehr
exaly   +3 more sources

Psilocin – The “real deal” or an extraction byproduct

Journal of Forensic Sciences, 2022
AbstractMost illicit drug casework samples at the Israel Police National Drug Laboratory are found to be mixtures of substances. Some are a mixture of an illicit drug with fillers, and others may contain more than one illicit drug. This study was triggered by a routine gas chromatography‐mass spectrometry (GC‐MS) analysis of an unusual casework sample.
Ori, Gutman, Dana, Tenne, Uriel, Bretler
openaire   +2 more sources

Immunochemical monitoring of psilocybin and psilocin to identify hallucinogenic mushrooms

Journal of Pharmaceutical and Biomedical Analysis, 2020
Development of rapid and reliable immunochemical methods for monitoring psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine; Pyb) and psilocin (dephosphorylated metabolite; Psi), the psychoactive compounds contained within hallucinogenic mushrooms (magic mushrooms), is desirable in order to identify these mushrooms and regulate their illicit use ...
Izumi Morita, Hiroyuki Oyama, Yuki Kiguchi   +2 more
exaly   +3 more sources

Detection of psilocin in body fluids

Forensic Science International, 2000
Active compounds of some mushrooms e.g. Psilocybe cubensis, Paneolus subalteatus or Stropharia coronilla, the psychotropic agents psilocybin and psilocin, have hallucinogenic effects. In one case of 'magic mushroom' intake, we had to analyse blood and urine. Psilocin was detected in the urine with REMEDi HS.
G, Sticht, H, Käferstein
openaire   +2 more sources

The fate of psilocin in the rat

Biochemical Pharmacology, 1962
Abstract The synthesis of 14 C-psilocin labelled in two different positions is described. The resorption, distribution, excretion and metabolism of psilocin in the rat was studied quantitatively with the labelled compounds.
F, KALBERER, W, KREIS, J, RUTSCHMANN
openaire   +2 more sources

The Detection of Psilocin in Human Urine

Journal of Forensic Sciences, 2001
Abstract Pharmacokinetic studies of psilocybin in humans have shown the rapid dephosphorylation of psilocybin to psilocin with further conversion to 4-hydroxy-tryptophole (4HT) and 4-hydroxyindole-3-acetic acid (4HIAA) in plasma. Our study shows that psilocin also undergoes conjugation and can be found in the urine as the psilocin ...
A F, Grieshaber, K A, Moore, B, Levine
openaire   +2 more sources

Metabolism of psilocybin and psilocin: clinical and forensic toxicological relevance

Drug Metabolism Reviews, 2017
Psilocybin and psilocin are controlled substances in many countries. These are the two main hallucinogenic compounds of the "magic mushrooms" and both act as agonists or partial agonists at 5-hydroxytryptamine (5-HT)2A subtype receptors. During the last few years, psilocybin and psilocin have gained therapeutic relevance but considerable physiological ...
Ricardo Jorge Dinis-Oliveira
exaly   +3 more sources

GLC-Mass Spectral Analysis of Psilocin and Psilocybin

Journal of Pharmaceutical Sciences, 1977
With the combined technique of GLC-mass spectrometry, psilocin and psilocybin, two hallucinogenic indoles, were analyzed as their trimethylsilyl derivatives. The method was applied to these two components in an extract of Psilocybe cubensis (Earle) Sing.
D B, Repke, D T, Leslie, D M, Mandell, N G, Kish   +3 more
openaire   +2 more sources

Comparison of psilocin with psilocybin, mescaline and LSD-25

Psychopharmacology, 1962
1. Reactions induced by LSD, mescaline, psilocin, and psilocybin are qualitatively similar. 2. The time course of the psilocin and psilocybin reactions are shorter than those of LSD or mescaline reactions. li 4. Psilocin is approximately 1.4 times as potent as psilocybin.
A B, WOLBACH, E J, MINER, H, ISBELL
exaly   +3 more sources

Psilocin, Bufotenine and Serotonin: Historical and Biosynthetic Observations

Journal of Psychedelic Drugs, 1979
(1979). Psilocin, Bufotenine and Serotonin: Historical and Biosynthetic Observations. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 61-69.
W S, Chilton, J, Bigwood, R E, Jensen
openaire   +2 more sources