Results 101 to 110 of about 8,581 (194)

The psychedelic psilocybin and light exposure have similar and synergistic effects on gene expression patterns in the visual cortex

Molecular Brain
Psilocybin, a psychedelic compound found in specific hallucinogenic mushrooms, is known to induce changes in visual perception and experience in humans.
Ram Harari, Dmitriy Getselter, Evan Elliott   +2 more
doaj   +1 more source

Psilocybin for major depressive disorder: a systematic review of randomized controlled studies

Frontiers in Psychiatry
ObjectivesThe purpose of this systematic review of randomized controlled trials (RCTs) was to evaluate the effectiveness, safety, and tolerability of psilocybin in adult patients with major depressive disorder (MDD).MethodsA systematic search (up to ...
Li-Juan Li, Yu Mo, Zhan-Ming Shi, Xing-Bing Huang, Xing-Bing Huang, Yu-Ping Ning, Yu-Ping Ning, Hua-Wang Wu, Hua-Wang Wu, Xin-Hu Yang, Xin-Hu Yang, Wei Zheng, Wei Zheng   +12 more
doaj   +1 more source

A Missing Voice? Peer Support Workers’ Perceptions of Psychedelic‐Assisted Therapy in Australia: A Cross‐Sectional Survey

Brain and Behavior, Volume 16, Issue 6, June 2026.
Despite their capacity to bridge providers and clients, peer support workers remain largely absent from Australia's emerging psychedelic‐assisted therapy (PAT) landscape. This study identifies a broadly supportive and optimistic PSW workforce, while highlighting the need for tailored education pathways and structured integration models to enable ...
Aloysius Amos Lau, Shalini Arunogiri, Boen Raner‐Galutera, Siegfried Lichtwark, Sarah J. Catchlove   +4 more
wiley   +1 more source

Amid magic and menace: psychiatrists' attitudes to psilocybin therapy.

OBJECTIVES Understanding variations in knowledge and attitudes of psychiatrists to psilocybin therapy is important for the collective discourse about the potential impact on clinical practice and public health in Ireland.
Ivers, Jo-Hanna, Tobin, Katy, Harrington, Colm, Hendricks, Peter S, Gribben, Andrew, Murnane, Kevin S, Kelly, John R, Thuery, Guillaume, Burke, Tara, Husein, Amanda, Harkin, Andrew   +10 more
core   +1 more source

Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis

Frontiers in Psychiatry
IntroductionThe subjective effects of psilocybin on obsessive-compulsive disorder (OCD) are under-explored. Therefore, we conducted a qualitative study of participant experiences from the first randomized placebo-controlled trial of single-dose ...
T. H. W. Ching, B. Stahnke, S. Shnayder, G. Agin-Liebes, T. G. Adams, L. Amoroso, O. Baiz, A. Belser, C. Bohner, M. Burke, E. D’Amico, G. DePalmer, J. Eilbott, G. Fram, R. Grazioplene, J. Hokanson, A. Jankovsky, S. A. Kichuk, B. Martins, P. Purohit, H. Schaer, Y. P. Sierra, C. Witherow, C. Pittenger, C. Pittenger, C. Pittenger, C. Pittenger, C. Pittenger, C. Pittenger, B. Kelmendi   +29 more
doaj   +1 more source

Expectations and Motivations for Participation in Clinical Trials Utilizing Psychedelics for Treatment‐Resistant Depression: A Qualitative Study

Brain and Behavior, Volume 16, Issue 6, June 2026.
Individuals with treatment‐resistant depression considering psychedelic trial participation were motivated by chronic illness, failed treatments, and hope for a novel intervention, while actively minimizing expectations to guard against disappointment.
Christopher Poppe, Liisa Lyck, Laura Bechtold, Dimitris Repantis   +3 more
wiley   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

The effect of psilocybin on empathy and prosocial behavior: a proposed mechanism for enduring antidepressant effects

npj Mental Health Research
Psilocybin is a serotonergic psychedelic shown to have enduring antidepressant effects. Currently, the mechanism for its enduring effects is not well understood. Empathy and prosocial behavior may be important for understanding the therapeutic benefit of
Kush V. Bhatt, Cory R. Weissman
doaj   +1 more source

Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats

Frontiers in Neuroscience
Psilocybin is a hallucinogen with complex neurobiological and behavioral effects. This is the first study to use MRI to follow functional changes in brain activity in response to different doses of psilocybin in fully awake, drug naive rats.
Evan Fuini, Arnold Chang, Richard J. Ortiz, Richard J. Ortiz, Taufiq Nasseef, Josh Edwards, Marc Latta, Elias Gonzalez, Taylor J. Woodward, Bryce Axe, Ashwath Maheswari, Noah Cavallaro, Heather B. Bradshaw, Praveen P. Kulkarni, Craig F. Ferris, Craig F. Ferris   +15 more
doaj   +1 more source

Japanese Cohort Study Identifies an Association Between the Serotonin Transporter–Linked Polymorphic Region and Suicide Death

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
The odds ratios and corresponding 95% confidence intervals for suicide death by 5‐HTTLPR S allele, in main and subgroup analyses. Statistical significance is indicated. ABSTRACT Introduction More than 720 000 individuals die by suicide annually worldwide, making it a major public health concern and a leading cause of death among young people ...
Shohei Okada, Toshiyuki Shirai, Masao Miyachi, Gentaro Yamasaki, Kiriko Minami, Ryo Tsukamoto, Kentaro Mouri, Takaki Tanifuji, Ryuichi Katada, Satoshi Okazaki, Ikuo Otsuka, Akitoyo Hishimoto   +11 more
wiley   +1 more source