Results 21 to 30 of about 18,448 (248)
Aging, 2022 Estrogen and its receptor play a positive role in the development of osteoarthritis (OA). Psoralen is a plant-derived estrogen analog. This study aimed to verify whether psoralen inhibits OA through an estrogen-like effect.
Kui Huang +9 more
semanticscholar +1 more source
Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 A small library of coumarin and their psoralen analogues EMAC10157a-b-d-g and EMAC10160a-b-d-g has been designed and synthesised to investigate the effect of structural modifications on their inhibition ability and selectivity profile towards carbonic ...
R. Meleddu +12 more
semanticscholar +1 more source
Experimental and Therapeutic Medicine, 2021 Psoralen, one of the active ingredients in Psoralea corylifolia, has been previously reported to regulate the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs).
Yong-quan Huang +6 more
semanticscholar +1 more source
A Typical Dermoscopic Pattern of PLEVA. [PDF]
Clin Case RepABSTRACT PLEVA is a benign inflammatory disorder. Dermoscopy is a non‐invasive diagnostic modality. Thus, the new dermoscopic pattern mentioned in our literature can aid in the diagnosis of the disease, unlike the skin biopsy, which is an invasive modality and shows non‐specific features in PLEVA.
Mathur M +5 more
europepmc +2 more sources
Inflammation, 2021 To study the effects of psoralen on the intestinal barrier and alveolar bone loss (ABL) in rats with chronic periodontitis. Fifty-two 8-week-old specific pathogen-free (SPF) male Sprague-Dawley (SD) rats were randomly divided into the following four ...
Hua Liu +6 more
semanticscholar +1 more source
Psoralen induces liver injuries through endoplasmic reticulum stress signaling in female mice
Drug and chemical toxicology (New York, N.Y. 1978), 2021 Psoralen is the main coumarin component of Fructus psoraleae. Previously, we have found that psoralen induced hepatocytes apoptosis via PERK and ATF6 related ER stress pathways in vitro.
Ruili Yu +7 more
semanticscholar +1 more source
Experimental and Therapeutic Medicine, 2021 Psoralen is an effective active component extracted from Psoraleacorylifolia, which can promote bone formation in osteoporotic animals. However, to the best of our knowledge, its effect on fracture healing has not yet been examined. In the present study,
Kui Huang +6 more
semanticscholar +1 more source
Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020 Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety.
semanticscholar +1 more source
Human MLH1 protein participates in genomic damage checkpoint signaling in response to DNA interstrand crosslinks, while MSH2 functions in DNA repair. [PDF]
PLoS Genetics, 2008 DNA interstrand crosslinks (ICLs) are among the most toxic types of damage to a cell. For this reason, many ICL-inducing agents are effective therapeutic agents.
Qi Wu, Karen M Vasquez
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2023 Objective To explore the mechanism of psoralen synergized with exosomes (exos)-loaded SPC25 on nucleus pulposus (NP) cell senescence in intervertebral disc degeneration (IVDD).
Lei Yang +6 more
doaj +1 more source