Results 111 to 120 of about 184,542 (286)
Quantification of Age and Sex Ratio Differences between Trial and Target Population for New Drugs
Clinical Pharmacology &Therapeutics, EarlyView.Clinical trials are essential to understand the benefit‐harm profile of new drugs. Lack of adequate representation in age and sex ratio in clinical trials can result, for example, in higher side effects for underrepresented patients. We quantified differences in age and sex ratios between trial and target populations of new drugs approved by the FDA ...
Miquel Serra‐Burriel +2 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott +7 more
wiley +1 more source
T‐Shaped 8‐Aryl(ethynyl)‐Substituted Psoralens With Tunable Charge‐Transfer Absorption
European Journal of Organic Chemistry, EarlyView.Starting from 8‐methoxypsoralen, new 8‐arylated and 8‐alkynylated psoralen derivatives are accessible by cross‐coupling. These T‐shaped π‐expanded chromophores are luminescent and photophysics reveal a highly polar excited state with tunable charge‐transfer character.
Lena T. Leusch, Thomas J. J. Müller
wiley +1 more source
Tocotrienols: A Review From Source to Therapeutic Applications
Food Frontiers, EarlyView.Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño +6 more
wiley +1 more source
Frontiers in ImmunologyBackgroundAcute generalized exanthematous pustulosis (AGEP) is a rare but severe cutaneous adverse reaction characterized by the abrupt onset of non-follicular sterile pustules on an erythematous and edematous background.
Ji-Na Zheng +8 more
doaj +1 more source
Secukinumab demonstrates greater sustained improvements in daily activities and personal relationships than ustekinumab in patients with moderate‐to‐severe plaque psoriasis: 52‐week results from the
, 2017 Andrew Blauvelt +11 more
openalex +1 more source
Food Frontiers, EarlyView.ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani +3 more
wiley +1 more source
Food Biomacromolecules, EarlyView.Abstract Honeybees (Apis mellifera L.) are an important class of insects that are the most beneficial in terms of economy. Beeswax is the second most important bee products after honey. Its commercial importance is due to its antimicrobial, antioxidant, anti‐inflammatory and antiseptic as well as regenerative properties.
Rajshri Naveen, Manickam Loganathan
wiley +1 more source
comment: Clinical evaluation of different therapeutic modalities in psoriasis by Pasi score [PDF]
, 2013 Hisayoshi Imanishi, Daisuke Tsuruta
openalex +1 more source