Results 121 to 130 of about 293,751 (369)

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and TYK2 Inhibitors via IL10 Antagonism

Arthritis &Rheumatology, Accepted Article.
Background JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but TYK2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn's Disease, which highlights the complex role for JAK‐STAT signaling in different inflammatory processes. In this study, we investigated
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbery, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Treatment of psoriasis with biologic agents in Malta [PDF]

, 2016
Introduction: Biologic therapy has revolutionalised the treatment of moderate to severe psoriasis leading to improved clinical outcomes and quality of life scores.
Aquilina, Susan, Boffa, Michael J., Clark, Eileen, Mercieca, Liam, Scerri, Lawrence   +4 more
core  

Circulating Tumour Necrosis Factor is highly correlated with brainstem serotonin transporter availability in humans [PDF]

, 2016
Preclinical studies demonstrate that pro-inflammatory cytokines increase serotonin transporter availability and function, leading to depressive symptoms in rodent models.
Burden, A. David, Cavanagh, Jonathan, Combet, Emilie, Hadley, Donald, Krishnadas, Rajeev, Leman, Joyce, McInnes, Iain B., Nicol, Alice, Pimlott, Sally, Puri, Navesh, Sassarini, Jen   +10 more
core   +1 more source

Mucosal‐associated invariant T cells in rheumatic diseases.

Arthritis &Rheumatology, Accepted Article.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor (TCR) and restriction by the MHC class I‐related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines. Upon activation, MAIT cells rapidly produce pro‐inflammatory cytokines,
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Real-life effectiveness of once-daily calcipotriol and betamethasone dipropionate gel vs. ointment formulations in psoriasis vulgaris: final analysis of the 52-week PRO-long study [PDF]

, 2015
Background: Topical therapies are the mainstay of treatment for psoriasis vulgaris. The fixed combination of calcipotriol (Cal) 50 mu g/g plus betamethasone 0.5 mg/g (as dipropionate; BD) is a first-line topical treatment and available as a gel or ...
Hol, CW, Lambert, Jo, Vink, J
core   +1 more source

General practitioner consultation for postmenopausal bleeding after COVID‐19 vaccination—a self‐controlled cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims The incidence of postmenopausal bleeding (PMB) has been increasing over the past years. Little is known about the risk of PMB after COVID‐19 vaccination. Our study aimed to investigate this based on routine general practitioner (GP) healthcare data from the Netherlands.
Rana Jajou, Eugène P. van Puijenbroek, Renee Veldkamp, Jetty A. Overbeek, Florence P. A. M. van Hunsel, Agnes C. Kant   +5 more
wiley   +1 more source

The metabolomics of psoriatic disease. [PDF]

, 2017
Metabolomics is an emerging new "omics" field involving the systematic analysis of the metabolites in a biologic system. These metabolites provide a molecular snapshot of cellular activity and are thus important for understanding the functional changes ...
Afifi, Ladan, Chang, Hsin Wen, Jeon, Caleb, Lee, Kristina, Liao, Wilson, Trivedi, Megha, Yan, Di   +6 more
core  

The relationship among the health-related quality of life, illness severity, personality and psychiatric symptoms in patients with psoriasis: an empirical investigation [PDF]

, 2019
Background: Psoriasis is a complex and chronic inflammatory skin disorder. The mechanisms underlying this immune-mediated disease are not clear, but some evidence indicates that specific personality features and symptom patterns may play an important ...
Annalisa Tanzilli, Denise Erbuto, Elena Rogante, Maurizio Pompili, Salvatore Sarubbi, Severino Persechino, Tommaso Boldrini, Vittorio Lingiardi   +7 more
core   +1 more source

Clinical and epidemiologic features of psoriasis patients in an Egyptian medical centerCapsule Summary

JAAD International, 2020
Background: Identification of epidemiologic and phenotypic variations of psoriasis among different ethnic groups can further our understanding of this perplexing disease, aiming at better management of patients worldwide.
Mohamed Hussein Medhat El-Komy, MD, Heba Mashaly, MD, Khadiga S. Sayed, MD, Vanessa Hafez, MD, Marwa S. El-Mesidy, MD, Eman R. Said, MD, Marwa A. Amer, MD, Aya M. AlOrbani, MD, Dina G. Saadi, MD, Mona El-Kalioby, MD, Reem O. Eid, MSc, Yousra Azzazi, MSc, Hagar El Sayed, MD, Nesrin Samir, MD, Marwa R. Salem, MD, Eman D. El Desouky, MD, Hesham Abd El-Moaty Zaher, MD, Hoda Rasheed, MD   +17 more
doaj  

CapsDeMM: Capsule network for Detection of Munro's Microabscess in skin biopsy images [PDF]

arXiv, 2018
This paper presents an approach for automatic detection of Munro's Microabscess in stratum corneum (SC) of human skin biopsy in order to realize a machine assisted diagnosis of Psoriasis. The challenge of detecting neutrophils in presence of nucleated cells is solved using the recent advances of deep learning algorithms.
arxiv