Results 81 to 90 of about 116,439 (236)

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Immunometabolic and Spatiotemporal Control of Tissue‐Resident Memory T Cell Biology

Barrier Immunity, EarlyView.
Tissue‐resident memory T (TRM) cells in barrier tissues provide a frontline defense against invading pathogens. Immune (Signals 1–3) and nutrient (Signal 4) cues play an integral role in directing TRM formation and heterogeneity. The spatial and temporal organization of these signals establishes durable TRM cells across tissues, enabling diverse ...
Jana L. Raynor, Hongbo Chi
wiley   +1 more source

Beeswax: Food and beyond

Food Biomacromolecules, EarlyView.
Abstract Honeybees (Apis mellifera L.) are an important class of insects that are the most beneficial in terms of economy. Beeswax is the second most important bee products after honey. Its commercial importance is due to its antimicrobial, antioxidant, anti‐inflammatory and antiseptic as well as regenerative properties.
Rajshri Naveen, Manickam Loganathan
wiley   +1 more source

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients

iMeta, EarlyView.
Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial‐driven sepsis from extensive skin barrier loss and subsequent scar formation. This makes MBI a compelling model for studying multi‐system microbial dysbiosis following skin barrier destruction.
Runzhi Huang, Yixu Li, Xiaoliang Li, Xulin Chen, Gang Xu, Shurun Huang, Weixi Yang, Xiaodong Li, Haiming Xin, Jianqiang Jiao, Hui Chen, Yuguo Xie, Peng Duan, Wenjun Liu, Xiangdong Deng, Zongyu Li, Yiping Xiu, Jiansheng Zheng, Rujun Chen, Zhaohong Chen, Xingang Wang, Xiaojian Li, Gaoxing Luo, Yi Zhang, Hongyan Zhang, Shichu Xiao, Liang Xiao, Ruijin Guo, Jie Zhang, Xiaofei Ye, Hongtai Tang, Qiao Zuo, Bin Qu, Bingwei Sun, Changhong Lu, Chengliang Deng, Deyi Zheng, Geng Ji, Haisheng Li, Haizhou Yu, Hua Zhou, Jian Wu, Lanjun Nie, Lei Wang, Pihong Zhang, Qingfu Zhang, Shengwu Chao, Sisi Yang, Xianglin Ding, Xiangsheng Ding, Ying Yan, Jiangyong Shen, Yongjian Zhao, Yunchuan Pan, Yunbiao Shen, Yu Zhang, Zhihui Yao, Zhe Cheng, Jiangfan Xie, Zhigang Chu, Shijie Li, Long Xu, Xiuming Yang, Sujie Xie, Hanlin Sun, Shuyuan Xian, Dezhi Han, Maolong Dong, Chengde Xia, Peng Luo, Yongming Yao, Zhaofan Xia, Shizhao Ji   +72 more
wiley   +1 more source

Exploring the Link Between Psoriasis and Genetic Predictors of Cardiac Magnetic Resonance Traits: A Bidirectional Mendelian Randomization Study

iNew Medicine, EarlyView.
ABSTRACT Psoriasis is a chronic autoimmune disease characterized by systemic inflammation and skin involvement, affecting millions of individuals worldwide. However, few studies have evaluated whether psoriasis and cardiac magnetic resonance imaging (CMR) traits share a common genetic basis.
Junlin Yang, Pengzhan Yin, Shutian An, Zhanglei Li, Yewen Jiang, Jun Wang, Yongqiang Yu, Ren Zhao, Xiaohu Li   +8 more
wiley   +1 more source

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

COVID-19 in patients with psoriasis: A Latin American case series

JAAD International, 2021
Isabela Campo-Slebi, MD, María Fernanda Meza-Corso, MD, Paola Cárdenas, MD, Juan Raúl Castro-Ayarza, MD, Cesar González, MD, Carolina Cortés, MD, Manuel Franco, MD, Fernando Valenzuela, MD   +7 more
doaj   +1 more source

Effectiveness of baricitinib in acquired reactive perforating collagenosis: a case report

Frontiers in Immunology
BackgroundAcquired reactive perforating collagenosis (ARPC) poses a clinical challenge with an unclear pathogenesis. This disease has been frequently proven resistant to immunosuppressive treatments, significantly affecting the quality of life of ...
Jianfeng Zheng, Jianfeng Zheng, Yangfeng Ding, Yangfeng Ding, Yuanyuan Chen, Yuanyuan Chen, Yuling Shi, Yuling Shi, Yunlu Gao, Yunlu Gao   +9 more
doaj   +1 more source

TAM pathway proteins as novel salivary biomarkers for periodontitis

Journal of Periodontology, EarlyView.
Abstract Background The identification of molecular biomarkers that help clinicians in early diagnosis is a key focus of periodontal research. The major aim of this cross‐sectional observational study was to assess whether salivary TAM pathway protein levels have the potential to discriminate between periodontally healthy or gingivitis controls and ...
Karina Mendes, Ana T. P. C. Gomes, Dimitris N. Tatakis, Tiago Marques, Marla Pinto, Pedro C. Lopes, Maria J. Correia, Nuno Rosa   +7 more
wiley   +1 more source

Outcomes and risk factors of COVID-19 in patients with bullous pemphigoid: a cross-sectional study

Frontiers in Immunology
BackgroundThe outcomes of coronavirus disease 2019 (COVID-19) in patients with bullous pemphigoid (BP) remain insufficiently understood. This study aimed to evaluate the impact of COVID-19 on BP patients and identify factors influencing the risk and ...
Yuexin Zhang, Yuexin Zhang, Dawei Huang, Dawei Huang, Yuling Shi, Yuling Shi, Yangfeng Ding, Yangfeng Ding, Yunlu Gao, Yunlu Gao   +9 more
doaj   +1 more source