Results 101 to 110 of about 131,822 (267)

Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life [PDF]

, 2003
Background: Older adults are the main recipients of repeat prescriptions for benzodiazepine (BZD) hypnotics. BZDs can impair cognitive function and may not aid sleep when taken continuously for years.
Collins, R., Curran, H.V., Fletcher, S., Iliffe, S., Kee, S.C.Y., Woods, B.   +5 more
core   +1 more source

Placebo in Paediatric Clinical Trials: Systematic Literature Review and Framework‐Based Synthesis

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Introduction Placebo‐controlled trials can provide strong evidence on safety and efficacy, but their ethical acceptability in paediatric research is contested because children have limited decisional capacity and placebo use may entail withholding effective therapy.
Georgia Parry, Artur Abelian, Chloe C. E. Williams, Lydia E. Roberts, Megan Athersmith, Louise Oni   +5 more
wiley   +1 more source

A proof-of-concept investigation into ketamine as a pharmacological treatment for alcohol dependence: study protocol for a randomised controlled trial

Trials, 2017
Background Worldwide, alcohol abuse is a burgeoning problem. Abstinence is key to allow recovery of physical and mental health as well as quality of life, but treatment for alcohol dependence is associated with high relapse rates.
Amy McAndrew, Will Lawn, Tobias Stevens, Lilla Porffy, Brigitta Brandner, Celia J. A. Morgan   +5 more
doaj   +1 more source

Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats [PDF]

, 2018
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages,
Acevedo, Adriani, Aleksandrov, Andersen, Atianjoh, Berardo, Brandon, Brunelle, Burke, Camarini, Chong, Crawford, Crowley, Cryan, Dalsgaard, Diaz Heijtz, Doremus-Fitzwater, Duke, Fahlke, Feltmann, Fernandez, Frey, Frolov, Gaytan, Gaytan, Gaytan, Gaytan, Gill, Gowin, Heinz, Izenwasser, Jones, Justo, Kameda, Karanikas, Karim, Kozanian, Krasnova, Kuczenski, Kuczenski, Lambert, Mandt, Mannuzza, McClintick, McCullough, McDougall, McDougall, Naimi, National-Research-Council, Pascual, Pilatti, Pilatti, Pilatti, Pinsky, Ponce, Quinn, Quinn, Renard, Ruiz, Salisbury, Schenk, Schuckit, Schuckit, Soeters, Spear, Spear, Sripada, Stewart, Strakowski, Tirelli, Vendruscolo, Venkataraman, Venniro, Wagner, Wetzell, Wille-Bille, Winer, Wolgin   +77 more
core   +1 more source

Lucid Dreaming Frequency Associated With Grey–White Matter Networks: An Exploratory Multimodal MRI Study

Journal of Sleep Research, EarlyView.
ABSTRACT Lucid dreaming, defined as the experience of becoming aware of dreaming while dreaming, offers a unique window into a state of consciousness characterised by a blending of the sensory vividness of REM sleep with the self‐awareness of wakefulness. While past functional imaging has shed light on the neural activity supporting lucid dreaming, the
Nicola De Pisapia, Erdem Taskiran, Stefano Mastino, Gabriele Penazzi, Alessandro Grecucci   +4 more
wiley   +1 more source

The effects of memantine on prepulse inhibition. [PDF]

, 2009
Reduced prepulse inhibition (PPI) of startle provides evidence of deficient sensorimotor gating in several disorders, including schizophrenia. The role of NMDA neurotransmission in the regulation of PPI is unclear, due to cross-species differences in the
Bergsma, F, Swerdlow, NR, Talledo, J, van Bergeijk, DP, Weber, E   +4 more
core   +2 more sources

Association of Glucagon‐Like Peptide‐1 Receptor Agonists and Suicidality: A Systematic Review

Obesity Reviews, EarlyView.
ABSTRACT Introduction Increased risk of suicidality has been reported in association with glucagon‐like peptide receptor agonist (GLP‐1 RA) prescription. Herein, we conducted a comprehensive review evaluating reports of GLP‐1 RA prescription and suicidality.
Hezekiah C. T. Au, Yang Jing Zheng, Gia Han Le, Sabrina Wong, Kayla M. Teopiz, Angela T. H. Kwan, Joshua D. Rosenblat, Rodrigo B. Mansur, Hayun Choi, Roger S. McIntyre   +9 more
wiley   +1 more source

Safety Profile and Neurocognitive Function Following Acute 4-Fluoroamphetamine (4-FA) Administration in Humans

Frontiers in Pharmacology, 2018
Availability of novel psychoactive substances (NPS) exponentially increased over the last years. Risk evaluations of NPS are hampered by the lack of pharmacological studies in humans on health parameters.
Elizabeth B. de Sousa Fernandes Perna, Eef L. Theunissen, Patrick C. Dolder, Natasha L. Mason, Nadia R. P. W. Hutten, Stefan W. Toennes, Kim P. C. Kuypers, Johannes G. Ramaekers   +7 more
doaj   +1 more source

Dopamine receptors gene expression in male rat hippocampus after administration of MDMA (Ecstasy) [La Expresión Génica de Receptores de Dopamina en el Hipocampo de Ratas Macho Después de la Administración de MDMA (Éxtasis)] [PDF]

, 2015
Ecstasy is one of the most popular amusing drugs among young people. Documents indicate some effects of Ecstasy on hippocampus and close relations between dopaminergic functions with reward learning. Therefore, the aim of this study was evaluation of the
Kamran, H., Majid, S., Mehrdad, J., Simin, M.   +3 more
core  

Links between trauma and psychotic symptoms: Integrating cognitive behavioural and neuropsychoanalytic models of psychosis

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Purpose Cognitive‐behavioural therapy for psychosis (CBTp) achieves small to modest effect sizes, which invites the question, ‘What clinical modifications might improve outcomes?’ This paper proposes an integration of CBTp with a neuropsychoanalytic approach that in clinical practice might extend the gains achieved by CBTp alone.
Michael Garrett
wiley   +1 more source