Results 71 to 80 of about 50,913 (300)

Decoding the Gut‐Brain Axis: Multi‐Omics Reveals a Causal Chain Linking Human Genome, Gut Microbiota, Blood Metabolites, and Alertness in the Brain

Med Research, EarlyView.
This multi‐omics study identified genetic loci, gut microbiota, blood metabolites, and gray matter volumes of orbitofrontal cortex and cerebellum that were potentially relevant to alerting in healthy Chinese adults. Subsequent two‐step one‐sample Mendelian randomization further revealed a serial mediation pathway: Bacteroides intestinalis influences ...
Hongru Li, Chuansheng Chen, Ofir Turel, Yu Pu, Hong Chen, Tingyong Feng, Jiang Qiu, Xu Lei, Qinghua He   +8 more
wiley   +1 more source

Psychopharmacology of Addiction [PDF]

Psikiyatride Güncel Yaklaşımlar, 2012
Addiction is a primary, chronic, neurobiological disease, with genetic, psychosocial, and environmental factors influencing its development. Developments in the psychopharmacology of addiction is much slower than the other disciplines of psychiatry.
Tugce Toker Ugurlu, Ceyhan Balci Sengul, Cem Sengul   +2 more
doaj  

Bone Adaptation and Labor Organization in Co‐Located Medieval Anatolian Populations

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT Skeletal evidence from geographically co‐located populations offers a rare opportunity to disentangle subsistence‐driven bone adaptation from socially organized labor. This study examines upper limb morphology in two Byzantine communities—the urban center of Tyana (10th–13th c.
Gökhan Çakan, Ahmet G. Erdemir, Adalet E. Yıldız, Üstün Aydıngöz, Osman Doğanay, Ömür Dilek Erdal   +5 more
wiley   +1 more source

Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6‐catalyzed metabolism of solanidine

Clinical and Translational Science
Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%–25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained.
Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden   +7 more
doaj   +1 more source

Validation of the Catatonia Quick Screen in the Original Bush‐Francis Catatonia Rating Scale Cohort

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Delayed catatonia diagnosis may cause preventable harm. The 4‐item Catatonia Quick Screen (CQS) allows rapid screening, but its specificity requires evaluation. We assessed CQS sensitivity and specificity using the original Bush Francis Catatonia Rating Scale (BFCRS) cohort.
James Luccarelli, Joshua Ryan Smith, Mark Kalinich, Jo Ellen Wilson, Jonathan P. Rogers, Stephan Heckers, Andrew Francis   +6 more
wiley   +1 more source

PSYCHOPHARMACOLOGY OF HYPNOTICS

Psychiatry and Clinical Psychopharmacology, 2021
The following article identifies the appropriate strategies for the prescription of hypnotic drugs. Initially, a clinical evaluation of insomnia is provided which includes definitions of good and poor sleepers and the physiology of sleep. The paper then
Michel Bourin, Brid. Àiene. Nic Dhonnchadha   +1 more
doaj  

Estimating thresholds for risk of cannabis use disorder using standard delta‐9‐tetrahydrocannabinol (THC) units

Addiction, EarlyView.
Abstract Background and aims Lower risk guidelines for safer levels of cannabis use could help to reduce the health burden posed by cannabis use disorder (CUD). We aimed to estimate risk thresholds for CUD based on delta‐9‐tetrahydrocannabinol (THC) consumption using standard THC units (1 unit = 5 mg THC).
Rachel Lees Thorne, Will Lawn, Kat Petrilli, Katie Trinci, Anya Borissova, Shelan Ofori, Claire Mokrysz, H. Valerie Curran, Lindsey A. Hines, Tom P. Freeman   +9 more
wiley   +1 more source

Psychopharmacology in dermatology [PDF]

Dermatologic Therapy, 2008
Many patients with skin disorders have psychologic issues associated with their chief complaints. Dermatologists who wish to help their patients with psychodermatologic conditions can greatly enhance their therapeutic armamentarium by becoming familiar with the use of a few selected psychotropic agents.
Chai Sue, Lee, Robert, Accordino, Josephine, Howard, John, Koo   +3 more
openaire   +2 more sources

The psychoactive effects of repeated ketamine infusions and their mechanistic role in the treatment of alcohol use disorder: Secondary analysis of a randomised controlled trial

Addiction, EarlyView.
Abstract Background and aims Ketamine assisted psychotherapy is a promising new treatment for alcohol use disorder (AUD). The psychoactive effects of repeated intravenous (IV) ketamine infusions in people with AUD and their mechanistic role in treating AUD are largely unknown.
Cassie Bloy, Ananya Sarma, Bethan Marsh, Lorna Hardy, Meryem Grabski, Merve Mollaahmetoglu, Joshua Shotton, Shamhethan Bhaskaran, Anne Lingford‐Hughes, H. Val Curran, Celia Morgan, Will Lawn   +11 more
wiley   +1 more source

Systematic Overview of Bacopa monnieri (L.) Wettst. Dominant Poly-Herbal Formulas in Children and Adolescents

Medicines, 2017
Background: The Ayurvedic medicinal system employs a holistic approach to health, utilising the synergistic properties of organic resources. Research into the Ayurvedic herb Bacopa monnieri (L.) Wettst. (B.monnieri) has reported improvements in cognitive
James D Kean, Luke A Downey, Con Stough
doaj   +1 more source