Results 51 to 60 of about 207,857 (302)

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

CausalCellInfer: Prioritizing Cell‐Type‐Specific Disease Associations From Genetically Predicted Transcriptomes in Biobank Cohorts

Advanced Science, EarlyView.
Bulk and genotype‐imputed transcriptomes obscure the cellular drivers of complex disease. CausalCellInfer resolves them by integrating invariant marker selection, deep learning deconvolution, and regularized matrix completion. Applied to ∼500 000 UK Biobank participants across 29 traits, it uncovers hallmark cell‐type proportion shifts, including ...
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak‐Chung Sham, Hon‐Cheong So   +6 more
wiley   +1 more source

Comprehensive review of multidimensional biomarkers in the ShangHai At Risk for Psychosis (SHARP) program for early psychosis identification

PCN Reports, 2023
Psychosis is recognized as one of the largest contributors to nonfatal health loss, and early identification can largely improve routine clinical activity by predicting the psychotic course and guiding treatment.
TianHong Zhang, LiHua Xu, XiaoChen Tang, YanYan Wei, YeGang Hu, HuiRu Cui, YingYing Tang, ChunBo Li, JiJun Wang   +8 more
doaj   +1 more source

Psychiatric morbidity preceding psychotic and non-psychotic depression [PDF]

European Psychiatry, 2011
IntroductionPsychotic depression differs significantly from non-psychotic depression in many aspects. These differences comprise etiology, severity, treatment response and prognosis.Objectives/aimsThe aim of the study was to assess the diversity of the psychiatric morbidity preceding psychotic and non-psychotic depression.MethodsDanish, register-based,
Østergaard, Søren Dinesen, Dinesen, Peter Thisted, Petrides, Georgios, Skadhede, Søren, Munk-Jørgensen, Povl, Nielsen, Jimmi   +5 more
openaire   +3 more sources

B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source

Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept

International Journal of Bipolar Disorders, 2022
Objective To compare characteristics of bipolar disorder patients diagnosed as DSM-5 types I (BD-1) vs. II (BD-2). Methods We compared descriptive, psychopathological, and treatment characteristics in a sample of 1377 consenting, closely and repeatedly ...
Leonardo Tondo, Alessandro Miola, Marco Pinna, Martina Contu, Ross J. Baldessarini   +4 more
doaj   +1 more source

Mood instability and psychosis: analyses of British national survey data [PDF]

, 2014
We used British national survey data to test specific hypotheses that mood instability (1) is associated with psychosis and individual psychotic phenomena, (2) predicts the later emergence of auditory hallucinations and paranoid ideation, and (3 ...
Marwaha, Steven, Broome, M. R., Marwaha, S, Broome, MR, Kuipers, Liz, Broome, Matthew R; id_orcid, Freeman, D, Kuipers, E, Bebbington, Paul, Freeman, D., Bebbington, PE, Bebbington, P. E., Broome, Matthew R., Marwaha, S., Freeman, Daniel, Bebbington, Paul E, Marwaha, Steven; id_orcid, Kuipers, E.; id_orcid, Kuipers, Elizabeth   +18 more
core   +1 more source

Negotiating contested spaces and places: Narratives of social suffering and resistance in racialized Cape Town communities

American Journal of Community Psychology, EarlyView.
Abstract This study employs a schizocartographic approach to explore community narratives of space, memory, and violence in Kraaifontein, Cape Town. Through participants' accounts, ordinary places—gardens, shops, blocks, sports grounds, and streets—emerge as ambivalent geographies where trauma, resilience, and belonging intersect.
Guido Veronese, Chiara Fiscone, Ashraf Kagee   +2 more
wiley   +1 more source

Pathways between childhood victimization and psychosis-like symptoms in the ALSPAC Birth Cohort [PDF]

, 2013
Background: Several large population-based studies have demonstrated associations between adverse childhood experiences and later development of psychotic symptoms.
Lewis, G., Maughan, B., Fisher, H. L., Lewis, Glyn, Fisher, Helen L; id_orcid, Schreier, Andrea, Lewis, Glyn H, Maughan, Barbara, Maughan, Barbara; id_orcid, Munafo, Marcus R., Wolke, D., Wolke, Dieter, Fisher, H., Zammit, Stanley, Munafò, Marcus R, Munafo, M. R., Schreier, A.   +16 more
core   +1 more source

Diagnosing the system: Mental health, necropolitical uncare, and the abolition of migration detention

American Journal of Community Psychology, EarlyView.
Abstract This article examines the psychological effects of migration detention in the European Union's Closed Controlled Access Center (CCAC) on Samos through an ecological lens. It explores a double normalization of suffering: the brutalization of necropolitical migration governance and the simultaneous understanding of resulting distress as an ...
Julia Manek
wiley   +1 more source