Results 21 to 30 of about 50,737 (331)

Free acquisition of psychotropic drugs by the Brazilian adult population and presence on the National List of Essential Medicines [PDF]

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2022
The aims of the present study were to estimate the free-of-charge acquisition of psychotropic drugs among Brazilian adults; analyze the distribution of psychotropics according to their presence on the Relação Nacional de Medicamentos Essenciais (RENAME ...
Patrícia Silveira Rodrigues   +3 more
doaj   +1 more source

Chemical Analysis of Suspected Unrecorded Alcoholic Beverages from the States of São Paulo and Minas Gerais, Brazil

open access: yesJournal of Analytical Methods in Chemistry, 2015
Our study analyzed 152 samples of alcoholic beverages collected from the states of São Paulo and Minas Gerais, Brazil, using gas chromatography with flame ionization detection (GC-FID) and mass spectrometry (GC-MS), Fourier transform infrared ...
Giuseppina Negri   +2 more
doaj   +1 more source

Analise Demografica e Socioeconomica do Uso e do Acesso a Medicamentos Antidepressivos no Brasil [PDF]

open access: yesarXiv, 2021
Depressive disorders, in addition to causing direct negative impacts on health, are also responsible for imposing substantial costs on society. In relation to the treatment of depression, antidepressants have proven effective, and, to the World Health Organization, access to psychotropic drugs for people with mental illnesses offers a chance of ...
arxiv  

Drug Selection via Joint Push and Learning to Rank [PDF]

open access: yesIEEE/ACM Transactions on Computational Biology and Bioinformatics ( Volume: 17, Issue: 1, 01 Jan.-Feb. 2020), 2018
Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection problem as to accurately predicting 1). the ranking positions of sensitive drugs and 2).
arxiv   +1 more source

Hyperbolic Molecular Representation Learning for Drug Repositioning [PDF]

open access: yesarXiv, 2022
Learning accurate drug representations is essential for task such as computational drug repositioning. A drug hierarchy is a valuable source that encodes knowledge of relations among drugs in a tree-like structure where drugs that act on the same organs, treat the same disease, or bind to the same biological target are grouped together.
arxiv  

Two parallel medial prefrontal cortex-amygdala pathways mediate memory deficits via glutamatergic projection in surgery mice

open access: yesCell Reports, 2023
Summary: The neural circuit mechanisms underlying postoperative cognitive dysfunction (POCD) remain elusive. We hypothesized that projections from the medial prefrontal cortex (mPFC) to the amygdala are involved in POCD.
Xiao-Yu Sun   +7 more
doaj  

AMFPMC -- An improved method of detecting multiple types of drug-drug interactions using only known drug-drug interactions [PDF]

open access: yesarXiv, 2023
Adverse drug interactions are largely preventable causes of medical accidents, which frequently result in physician and emergency room encounters. The detection of drug interactions in a lab, prior to a drug's use in medical practice, is essential, however it is costly and time-consuming.
arxiv  

Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B

open access: yesActa Pharmaceutica Sinica B, 2023
Colorectal cancer (CRC) is a type of malignant tumor that seriously threatens human health and life, and its treatment has always been a difficulty and hotspot in research.
Haowei Liu   +5 more
doaj  

Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration

open access: yesHuman Brain Mapping, Volume 44, Issue 1, Page 245-257, January 2023., 2023
In older adults who experienced the death of a partner, higher prolonged grief symptoms were associated with less anticorrelation between retrosplenial default network and cingulo‐opercular networks during resting state, and more dwell time in a dynamic functional connectivity state involving positive correlations between large‐scale brain networks ...
Saren H. Seeley   +3 more
wiley   +1 more source

NeuroCADR: Drug Repurposing to Reveal Novel Anti-Epileptic Drug Candidates Through an Integrated Computational Approach [PDF]

open access: yesarXiv, 2023
Drug repurposing is an emerging approach for drug discovery involving the reassignment of existing drugs for novel purposes. An alternative to the traditional de novo process of drug development, repurposed drugs are faster, cheaper, and less failure prone than drugs developed from traditional methods.
arxiv  

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