Results 51 to 60 of about 50,737 (331)
Animal Models and Experimental Medicine, EarlyView.In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang +5 more
wiley +1 more source
High prevalence of prescription of psychotropic drugs for older patients in a general hospital
BMC Pharmacology and Toxicology, 2017 Background Many elderly patients receive psychotropic drugs. Treatment with psychotropic agents is associated with serious side effects including an increased risk of falls and fractures.
Inken Arnold +7 more
doaj +1 more source
A clustering and graph deep learning-based framework for COVID-19 drug repurposing [PDF]
arXiv, 2023 Drug repurposing (or repositioning) is the process of finding new therapeutic uses for drugs already approved by drug regulatory authorities (e.g., the Food and Drug Administration (FDA) and Therapeutic Goods Administration (TGA)) for other diseases. This involves analyzing the interactions between different biological entities, such as drug targets ...
arxiv
Annals of Neurology, EarlyView.Objective The objective is to evaluate cognitive and behavioral progression and identify early predictors of these changes in a cohort of amyotrophic lateral sclerosis (ALS) patients. Methods A total of 161 ALS patients were tested at diagnosis (T0), and 107 were re‐tested after 1 year (T1) using cognitive/behavioral tests. All patients underwent whole‐
Barbara Iazzolino +13 more
wiley +1 more source
Key Factors that Influence Consumer Preferences for Natural‐Hyped Products
Psychology &Marketing, Volume 40, Issue 2, Page 373-390, February 2023., 2023 Abstract Natural‐hyped products are receiving greater attention from and acceptance by consumers worldwide. Environmental factors that foster the demand for natural‐hyped products, specifically hemp‐based products include the deregulation of the cannabis industry and greater consumer desire for natural foods.
Franklin Velasco +3 more
wiley +1 more source
STAR Protocols, 2023 Summary: Analysis of synaptic strength and plasticity provides functional insights of complicated neural circuits. Here, we describe steps for cell- and projection-specific optogenetic manipulation of divergent basal ganglia circuits using anterograde ...
Ya-Wei Ji +4 more
doaj
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
BMC Psychiatry, 2020 Background Research suggests that economic recessions might be associated with a higher use of psychotropic drugs, but literature is scarce and contradictory in identifying the most vulnerable groups. This study aims to assess possible changes in the use
Manuela Silva +6 more
doaj +1 more source
Drug prescription clusters in the UK Biobank: An assessment of drug-drug interactions and patient outcomes in a large patient cohort [PDF]
arXiv, 2022 In recent decades, there has been an increase in polypharmacy, the concurrent administration of multiple drugs per patient. Studies have shown that polypharmacy is linked to adverse patient outcomes and there is interest in elucidating the exact causes behind this observation.
arxiv
Nursing Open, Volume 10, Issue 2, Page 1016-1028, February 2023., 2023 Abstract Aim The aim of the study was to reach consensus on modifiable risk factors for a novel system of care to address Manifestations of Frailty in hospitalized older adults. Design Consensus study. Method A modified nominal group technique, incorporating expert group face‐to‐face interaction, review of existing evidence and pre/post‐meeting ...
Susanne Coleman +17 more
wiley +1 more source