Results 81 to 90 of about 100,051 (354)

Studies on the Stability and Microbial Biotransformation of Five Deschloroketamine Derivatives as Prerequisite for Wastewater‐Based Epidemiology Screening

Drug Testing and Analysis, EarlyView.
Microbial biotransformation and stability of deschloroketamine derivatives and their metabolites in WW by incubating parent compounds, rat urine, or rat feces showed that deschloroketamine parents and Phase I metabolite were still detectable and that Phase II metabolites decreased in peak areas.
Fabian Frankenfeld, Lea Wagmann, Markus R. Meyer   +2 more
wiley   +1 more source

Current Concepts on Drug Abuse and Dependence [PDF]

, 2015
Drug addiction is a complex disease characterized by compulsive and uncontrollable desire to seek and consume the drug. In time, drug-related terminology has undergone many changes, arising from the deepening of the mechanisms of action, but also about ...
Baconi, Daniela Luiza, Bălălău, Cristian, Ciobanu, Anne-Marie, Cobani, Oana Denisa, Negrei, Carolina, Vlăsceanu, Ana Maria   +5 more
core   +2 more sources

Risk of suicide during treatment with venlafaxine, italopram, fluoxetine, and dothiepin : retrospective cohort study [PDF]

, 2006
Objective To compare the risk of suicide in adults usingthe antidepressant venlafaxine compared with citalopram, fluoxetine, and dothiepin. Design Retrospective cohort study. Setting UK General Practice Research Database. Participants 219 088 patients,
Andrews, Elizabeth, Mines, Daniel, Roskell, Neil, Rubino, Annalisa, Tennis, Pat, Weich, Scott   +5 more
core   +2 more sources

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

Drug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer, Maria Carmela Emanuele, Brianna N. Stang, Katleen Van Uytfanghe, Jessica Masson, Xavier Bouvot, Catherine Lamoureux, Alessandro Proposito, Fabiano Reniero, Margaret V. Holland, Alex J. Krotulski, Luisa Mannina, Christophe P. Stove, Claude Guillou   +13 more
wiley   +1 more source

Psychotropic drugs in Nepal: perceptions on use and supply chain management

Globalization and Health, 2018
Background Psychotropic drugs play an important role in the treatment of mental, neurological and substance use disorders. Despite the advancement of the use of psycho-pharmaceuticals in the developed countries, the psychotropic drug production and ...
Nawaraj Upadhaya, Mark J. D. Jordans, Dristy Gurung, Ruja Pokhrel, Ramesh P. Adhikari, Ivan H. Komproe   +5 more
doaj   +1 more source

Medicaid Policy Changes in Mental Health Care and Their Effect on Mental Health Outcomes [PDF]

In recent years, Medicaid has experienced a dramatic increase in spending on prescription drugs in general and psychotropic medications in particular.
Alison Cuellar, Sara Markowitz
core  

Rapid and Simple Dispersive Liquid–Liquid Microextraction (DLLME) Sample Preparation for Propofol Analysis in Hair, Blood, and Urine by Gas Chromatography–Mass Spectrometry

Drug Testing and Analysis, EarlyView.
Development and validation of an extraction method based on dispersive liquid–liquid microextraction for the analysis by GC–MS of propofol in three different biological samples (blood, urine, and hair). The proposed method is very simple and rapid.
Sara Odoardi, Serena Mestria, Valeria Valentini, Giulia Biosa, Sabina Strano Rossi   +4 more
wiley   +1 more source

MOTS-c is an effective target for treating cancer-induced bone pain through the induction of AMPK-mediated mitochondrial biogenesis

Acta Biochimica et Biophysica Sinica
Bone cancer pain (BCP), due to cancer bone metastasis and bone destruction, is a common symptom of tumors, including breast, prostate, and lung tumors. Patients often experience severe pain without effective treatment.
Yang Long, Li Miaomiao, Liu Yucheng, Bai Yang, Yin Tianyu, Chen Yangyang, Jiang Jinhong, Liu Su   +7 more
doaj   +1 more source

Topical and Systemic Cannabidiol Improves Trinitrobenzene Sulfonic Acid Colitis in Mice [PDF]

, 2012
Background/Aims: Compounds of Cannabis sativa are known to exert anti-inflammatory properties, some of them without inducing psychotropic side effects. Cannabidiol (CBD) is such a side effect-free phytocannabinoid that improves chemically induced colitis
Ashton CH, Bergamaschi MM, Borrelli F, Christensen R, Costa B, Cunha JM, Danese S, Engel MA, Huestis MA, Izzo AA, Izzo AA, Járai Z, Karschner EL, Kimball ES, Krawisz JE, Lal S, Loftus, Marquéz L, Martin Storr, Massa F, Pertwee RG, Pertwee RG, Rudolf Schicho, Ryberg E, Schicho R, Schicho R, Schuelert N, Schölmerich J, Sibaev A, Stintzing S, Storr MA, Storr MA   +31 more
core   +1 more source

Workplace Drug Testing—Prevalence of Positive Test Results, Most Common Substances, and Importance of Medical Review

Drug Testing and Analysis, EarlyView.
Among 23,900 urine and oral fluid drug tests from Swedish workplaces, 4.6% tested positive for controlled substances. Cannabis, amphetamine, cocaine and benzodiazepines were most common. Many samples containing opiates, amphetamine or benzodiazepines were MRO verified as being due to medical prescriptions, while cannabis or cocaine were almost entirely
Anders Helander, Fredrik Sparring
wiley   +1 more source