Results 81 to 90 of about 50,737 (331)

Human phase‐I metabolism of three synthetic cannabinoids bearing a cumyl moiety and a cyclobutyl methyl or norbornyl methyl tail: Cumyl‐CBMEGACLONE, Cumyl‐NBMEGACLONE, and Cumyl‐NBMINACA

Drug Testing and Analysis, EarlyView.
The human phase‐I metabolism of three SCRAs bearing a cumyl moiety and a CBM or NBM tail, based on LC‐qToF‐MS data of authentic urine specimens. Abstract Synthetic cannabinoid receptor agonists (SCRAs) continue to show high prevalence on the new psychoactive substances drug market.
Arianna Giorgetti, Pietro Brunetti, Belal Haschimi, Benedikt Pulver, Jennifer Paola Pascali, Jan Riedel, Volker Auwärter   +6 more
wiley   +1 more source

Caffeine facilitates extinction of auditory fear conditioning in rats

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 521-525, December 2022., 2022
Abstract Caffeine is the most widely consumed psychostimulant drug which could affect learning and memory acting through central adenosine receptors. Although caffeine has been suggested to impair the acquisition and the expression of auditory fear conditioning, its effect on the extinction has not been elucidated. To address this issue, in the present
Takaaki Ozawa, Kodai Kaseda, Yukio Ichitani, Kazuo Yamada   +3 more
wiley   +1 more source

Psychotropic drugs in Nepal: perceptions on use and supply chain management

Globalization and Health, 2018
Background Psychotropic drugs play an important role in the treatment of mental, neurological and substance use disorders. Despite the advancement of the use of psycho-pharmaceuticals in the developed countries, the psychotropic drug production and ...
Nawaraj Upadhaya, Mark J. D. Jordans, Dristy Gurung, Ruja Pokhrel, Ramesh P. Adhikari, Ivan H. Komproe   +5 more
doaj   +1 more source

Waxy‐ or Putty‐Like Materials as a Novel Drug Preparation for Synthetic Cannabinoid Receptor Agonists: Detection in Prisons and In Vitro Cannabinoid Receptor Activity

Drug Testing and Analysis, EarlyView.
Waxy‐ or putty‐like materials has emerged as a novel drug preparation for synthetic cannabinoids and other drugs in UK prisons. An in vitro CB1 bioassay was used to evaluate the CB1 activating potential of MDMB‐INACA and extracts from eight seized samples. MDMB‐INACA had moderate efficacy but low potency at CB1.
Axelle Timmerman, Marie H. Deventer, Rachael Andrews, Robert Reid, Victoria Marland, Darren Edwards, Christopher R. Pudney, Niamh Nic Daéid, Christophe P. Stove, Caitlyn Norman   +9 more
wiley   +1 more source

A preliminary study on predictors of treatment response to repetitive transcranial magnetic stimulation in patients with treatment‐resistant depression in Japan

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 478-484, December 2022., 2022
Abstract Background Brain imaging studies have reported that the effect of repetitive transcranial magnetic stimulation (rTMS) is associated with the activities of the dorsolateral prefrontal cortex (DLPFC) and ventral medial prefrontal cortex (VMPFC). However, few studies have been conducted in Japanese patients. Aim We aimed to identify brain regions
Haruki Ikawa, Mamoru Tochigi, Yoshihiro Noda, Hiroshi Oba, Tatsuro Kaminaga, Keita Sakurai, Emi Ikebuchi, Naoki Hayashi, Hiroshi Kunugi   +8 more
wiley   +1 more source

MOTS-c is an effective target for treating cancer-induced bone pain through the induction of AMPK-mediated mitochondrial biogenesis

Acta Biochimica et Biophysica Sinica
Bone cancer pain (BCP), due to cancer bone metastasis and bone destruction, is a common symptom of tumors, including breast, prostate, and lung tumors. Patients often experience severe pain without effective treatment.
Yang Long, Li Miaomiao, Liu Yucheng, Bai Yang, Yin Tianyu, Chen Yangyang, Jiang Jinhong, Liu Su   +7 more
doaj   +1 more source

Associations Between Self‐Reported Cocaine Use Patterns and Cocaine and Its Metabolites in Hair: Implications for Clinical and Forensic Practices

Drug Testing and Analysis, EarlyView.
This study demonstrates that concentrations of cocaine and its main metabolites in hair reliably predict an individual's actual intensity of cocaine use and effectively differentiate between dependent and non‐dependent users. ABSTRACT In forensic toxicology, it has been debated if hair testing allows an estimation of the intensity of cocaine use—an ...
Simon Grison, Lydia Johnson‐Ferguson, Matthias Vonmoos, Markus R. Baumgartner, Boris B. Quednow   +4 more
wiley   +1 more source

Development of individual fitness score for conformity of prescriptions to the “Guidelines For Pharmacological Therapy of Schizophrenia”

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 502-509, December 2022., 2022
Abstract Aims The Guidelines for the Pharmacotherapy of Schizophrenia were established to improve the quality of medical care, and the EGUIDE project was conducted to train clinicians on guideline usage. A quality indicator (QI) was established to measure the prevalence of the guidelines, and a survey was conducted, which revealed a gap between the ...
Ken Inada, Kentaro Fukumoto, Naomi Hasegawa, Yuka Yasuda, Hisashi Yamada, Hikaru Hori, Kayo Ichihashi, Hitoshi Iida, Kazutaka Ohi, Hiroyuki Muraoka, Fumitoshi Kodaka, Kenta Ide, Naoki Hashimoto, Jun‐ichi Iga, Kazuyoshi Ogasawara, Kiyokazu Atake, Yoshikazu Takaesu, Tatsuya Nagasawa, Hiroshi Komatsu, Tsuyoshi Okada, Ryuji Furihata, Mikio Kido, Saya Kikuchi, Chika Kubota, Manabu Makinodan, Shinichiro Ochi, Masahiro Takeshima, Hirotaka Yamagata, Junya Matsumoto, Kenichiro Miura, Masahide Usami, Taishiro Kishimoto, Toshiaki Onitsuka, Eiichi Katsumoto, Akitoyo Hishimoto, Shusuke Numata, Norio Yasui‐Furukori, Koichiro Watanabe, Ryota Hashimoto   +38 more
wiley   +1 more source

Drug-drug interaction prediction based on co-medication patterns and graph matching [PDF]

arXiv, 2019
Background: The problem of predicting whether a drug combination of arbitrary orders is likely to induce adverse drug reactions is considered in this manuscript. Methods: Novel kernels over drug combinations of arbitrary orders are developed within support vector machines for the prediction.
arxiv  

Analytical and Pharmacological Characterization of 1‐(Furan‐2‐Carbonyl)‐LSD (1F‐LSD) and Comparison With 1‐(Thiophene‐2‐Carbonyl)‐LSD (1T‐LSD)

Drug Testing and Analysis, EarlyView.
The novel lysergamide 1‐(furan‐2‐carbonyl)‐LSD (1F‐LSD) was analytically characterized. 1F‐LSD showed LSD‐like activity in vivo similar to 1‐(thiophene‐2‐carbonyl)‐LSD (1T‐LSD) used for comparison. Administration studies in mice and LC–MS analysis revealed that 1F‐LSD served as a prodrug.
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare, Simon P. Elliott, Alexander Stratford, Adam L. Halberstadt   +5 more
wiley   +1 more source