Results 151 to 160 of about 4,068 (193)

Comparative void-volume analysis of psychrophilic and mesophilic enzymes: Structural bioinformatics of psychrophilic enzymes reveals sources of core flexibility [PDF]

BMC Structural Biology, 2011
Abstract Background Psychrophiles, cold-adapted organisms, have adapted to live at low temperatures by using a variety of mechanisms. Their enzymes are active at cold temperatures by being structurally more flexible than mesophilic enzymes.
Kyle E Watters, Christopher Bystroff, Jonathan S Dordick   +2 more
exaly   +5 more sources

Psychrophilic enzymes: structural adaptation, pharmaceutical and industrial applications

Applied Microbiology and Biotechnology, 2021
Psychrophiles are cold-living microorganisms synthesizing enzymes that are permanently active at almost near-zero temperatures. Psychrozymes are supposed to be structurally more flexible than their homologous proteins. This structural flexibility enables these proteins to undergo conformational changes during catalysis and improve catalytic efficiency ...
Sepideh Parvizpour, Mohd Shahir Shamsir, Jafar Razmara   +2 more
exaly   +5 more sources

Psychrophilic enzymes: a thermodynamic challenge

BBA - Proteins and Proteomics, 1997
Psychrophilic microorganisms, hosts of permanently cold habitats, produce enzymes which are adapted to work at low temperatures. When compared to their mesophilic counterparts, these enzymes display a higher catalytic efficiency over a temperature range of roughly 0-30 degrees C and a high thermosensitivity.
Charles Gerday, Jean Louis Arpigny, Etienne Baise   +2 more
exaly   +4 more sources

Machine learning techniques for differentiating psychrophilic and non-psychrophilic bacterial α/β hydrolase enzymes

Biologia (Poland)
Psychrophilic enzymes represent a category of macromolecules that have acquired specific properties that enable these enzymes to perform their catalytic activity at low temperatures with high efficiency. One of the factors contributing to their adaptation is increased active site flexibility. Psychrophilic enzymes are of significant industrial interest
Nurcan Vardar-Yel
exaly   +4 more sources

Structural adaptation to low temperatures − analysis of the subunit interface of oligomeric psychrophilic enzymes [PDF]

FEBS Journal, 2007
Enzymes from psychrophiles show higher catalytic efficiency in the 0–20 °C temperature range and often lower thermostability in comparison with meso/thermophilic homologs. Physical and chemical characterization of these enzymes is currently underway in order to understand the molecular basis of cold adaptation.
Francesco Bossa, Stefano Pascarella
exaly   +5 more sources

Psychrophilic enzymes: revisiting the thermodynamic parameters of activation may explain local flexibility

BBA - Proteins and Proteomics, 2000
Basic theoretical and practical aspects of activation parameters are briefly reviewed in the context of cold-adaptation. In order to reduce the error impact inherent to the transition state theory on the absolute values of the free energy (DeltaG(#)), enthalpy (DeltaH(#)) and entropy (DeltaS(#)) of activation, it is proposed to compare the variation of
Thierry Lonhienne, Charles Gerday, Georges Feller   +2 more
exaly   +4 more sources

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Psychrophilic enzymes: hot topics in cold adaptation

Nature Reviews Microbiology, 2003
More than three-quarters of the Earth's surface is occupied by cold ecosystems, including the ocean depths, and polar and alpine regions. These permanently cold environments have been successfully colonized by a class of extremophilic microorganisms that are known as psychrophiles (which literally means cold-loving).
Georges Feller, Charles Gerday, Feller Georges   +2 more
exaly   +4 more sources

Heat-labile Enzymes in a Psychrophilic Bacterium

Journal of Bacteriology, 1967
The oxidative and fermentative activities of a psychrophilic bacterium (strain 82), whose maximal growth temperature is 35 C, were completely destroyed by exposure of the cells to 46 C for about 1 hr, whereas those of mesophilicEscherichia coliwere unaffected. Similar results were obtained with cell-free extracts.
K, Purohit, J L, Stokes
openaire   +2 more sources

Psychrophilic Enzymes: Cool Responses to Chilly Problems

, 2011
Georges Feller, Feller Georges
exaly   +3 more sources

Enzyme Catalysis in Psychrophiles

2017
Cold-active enzymes are produced by organisms, known as psychrophiles, adapted to permanently cold habitats. Low temperatures have an exponential deleterious effct on reaction rates, and thus psychrophilic enzymes have to be adapted to secure appropriate reaction rates in their environment.
Collins, Tony, Gerday, Charles
openaire   +2 more sources