Results 71 to 80 of about 22,716 (169)

Depletion of LncRNA NEAT1 Rescues Mitochondrial Dysfunction Through NEDD4L-Dependent PINK1 Degradation in Animal Models of Alzheimer’s Disease

Frontiers in Cellular Neuroscience, 2020
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and the main cause of dementia among the elderly worldwide. Unfortunately, the mechanism of AD remains unclear, and no effective therapies are available yet.
Zhonghua Huang, Jing Zhao, Wei Wang, Jun Zhou, Jie Zhang   +4 more
doaj   +1 more source

GSK3α‐mediated regulation of the RNA demethylase fat mass and obesity‐associated protein (FTO) during murine spermatogenesis

The FEBS Journal, EarlyView.
FTO regulates mRNA stability and translational efficiency through its m6A‐demethylation activity. GSK3 functions as an upstream regulator of FTO, leading to its inhibition via phosphorylation. In male germ cells, FTO activity is kept in check by GSK3α.
Neha Choudhari, Budheswar Dehury, Rounak Roy, Radhakrishnan Periyasamy, Indrashis Bhattacharya, Mahesh Sahare, Srinivasan Vijayraghavan, Souvik Dey   +7 more
wiley   +1 more source

Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader‐Willi syndrome

The Journal of Physiology, EarlyView.
Abstract figure legend Prader‐Willi syndrome (PWS) originates from deficiencies in chromosome 15q11‐13 region clustering around a critical region containing multiple‐repeat non‐coding RNA gene Snord116, resulting in metabolic and behavioural abnormalities leading to hyperphagia and obesity.
Volodymyr Rybalchenko, Ryan Butler
wiley   +1 more source

Targeting Spatiotemporal Heterogeneity of oncomiRNAs: A New Frontier in Cancer Therapy

Cancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background miRNAs are short RNA transcripts that modulate gene expression after transcription and have emerged as pivotal regulators of cancer biology. A subset, termed oncomiRNAs, functions as oncogenes or tumor suppressors, influencing key cellular events such as cell growth, programmed cell death, neovascularization, tissue invasion, and ...
T. Jeethy Ram, Muralee Damodaran
wiley   +1 more source

Mesenchymal stem cell‐derived exosomes for cardiac repair: Challenges, standardization gaps and a realistic path to clinical translation

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Mesenchymal stem cell‐derived exosomes (MSC‐sEVs) show preclinical promise for cardiac repair via anti‐inflammatory, anti‐apoptotic, pro‐angiogenic and anti‐fibrotic effects. However, translational hurdles remain, including non‐standardized isolation, unvalidated potency assays, incomplete GMP manufacturing, and lack of completed Phase II/III trials ...
Sakhavat Abolhasani, Yasin Ahmadi, Amin Jalizih   +2 more
wiley   +1 more source

Additional file 1: of miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

, 2016
Knock-down of DICER1 decreased miRNA levels. HeLa cells were transfected with 50 nM of DICER1 siRNA (DICER1 KD) or negative control (Ctl). 48 h post-transfection, representative miRNA levels were analyzed by qRT-PCR and were quantified as a percentage of control (n = 2). Values are mean ± SEM. (PDF 18 kb)
Jaekwang Kim, Fiesel, Fabienne, Belmonte, Krystal, Hudec, Roman, Wang, Wang-Xia, Chaeyoung Kim, Nelson, Peter, Springer, Wolfdieter, Jungsu Kim   +8 more
openaire   +1 more source

Integrin α5β1 in pancreatic ductal adenocarcinoma: Tumour‒stroma crosstalk, hypoxia and therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ITGA5/integrin α5β1 promotes PDAC progression by integrating fibronectin‐dependent adhesion, hypoxia‐associated ECM remodelling, pancreatic stellate cell/cancer‐associated fibroblast activation, desmoplasia and tumour‒stroma crosstalk. These processes contribute to impaired drug delivery and therapeutic resistance.
Chenzhe Ma, Yingying Wang, Yumin Li
wiley   +1 more source

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions.

PLoS ONE, 2015
Mutations of the PTEN-induced putative kinase 1 (PINK1) gene are a cause of autosomal recessive forms of Parkinson's disease. Recent studies have revealed that PINK1 is an essential factor for controlling mitochondrial quality, and that it protects cells
Hitoshi Murata, Hitoshi Takamatsu, Sulai Liu, Ken Kataoka, Nam-Ho Huh, Masakiyo Sakaguchi   +5 more
doaj   +1 more source

Elucidating the Mechanisms of Trichloroethylene‐Induced Kidney Cancer: Network Toxicology, Molecular Docking, and In Vitro Validation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
An integrated network toxicology, molecular docking, and in vitro validation approach was applied to identify TP53, ACTB, and CASP3 as key targets mediating trichloroethylene‐driven kidney carcinogenesis via aberrant signaling regulation. ABSTRACT Trichloroethylene (TCE), a pervasive environmental contaminant, is epidemiologically linked to kidney, but
Weijie Ma, Hui Cai
wiley   +1 more source

Additional file 4: of miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

, 2016
The levels of miR-27a (a) and miR-27b (b) in the luciferase assay. HeLa cells were transfected with miR-27a/b or negative control (Ctl) along with the reporter constructs as indicated in the X axis. 48 h post-transfection, miR-27a/b levels were measured by qRT-PCR. Each level was normalized to the corresponding U6 level. Data are shown as a fold change
Jaekwang Kim, Fiesel, Fabienne, Belmonte, Krystal, Hudec, Roman, Wang, Wang-Xia, Chaeyoung Kim, Nelson, Peter, Springer, Wolfdieter, Jungsu Kim   +8 more
openaire   +1 more source