Results 91 to 100 of about 22,716 (169)

Therapeutic intervention with sinomenine and irisin to preserve cardiac function after ischaemia–reperfusion injury

Experimental Physiology, Volume 111, Issue 8, Page 3557-3569, 1 August 2026.
Abstract Despite advancements in reperfusion therapy, myocardial ischaemia–reperfusion (IR) injury remains a major clinical challenge. This study investigated whether a novel dual‐target pre‐conditioning strategy using sinomenine and irisin could enhance myocardial resistance against IR injury. Ninety male Sprague–Dawley rats were utilized.
Lianjun Wu, Sining Bi, Amany Belal, Zhuzhu Liu   +3 more
wiley   +1 more source

Additional file 3: of miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

, 2016
a Comparison of 3′UTR sequences of PINK1 mRNAs from different species. Multiple alignment was performed using ClustalW program with 3′UTR sequences of PINK1 mRNAs from human (NM_032409), chimpanzee (XM_001164912), monkey (XM_001096957), rat (NM_001106694), and Mouse (NM_026880). Seed match sites for miR-27a/b are highlighted in red.
Kim, Jaekwang, Fiesel, Fabienne, Belmonte, Krystal, Hudec, Roman, Wang, Wang-Xia, Kim, Chaeyoung, Nelson, Peter, Springer, Wolfdieter, Kim, Jungsu   +8 more
openaire   +1 more source

A high‐fat, high‐sucrose diet exacerbates muscle and metabolic pathology and undermines glucocorticoid efficacy in dystrophin‐deficient mice

The Journal of Physiology, Volume 604, Issue 15, Page 6440-6464, 1 August 2026.
Abstract figure legend A high‐fat, high‐sucrose diet (HFHSD) exacerbated muscle and metabolic dysregulation in mdx mice while also altering the physiological response to prednisolone (Pred) In diaphragms of control diet (CD)‐fed mdx mice, prednisolone treatment improved muscle function and reduced fibrosis, inflammatory signalling, and mitochondrial ...
Morgan E. Vorwald, Swathy Krishna, Ji Heun Lee, Melissa Roths, Rudy J. Valentine, Joshua T. Selsby   +5 more
wiley   +1 more source

Acylglycerol Kinase Inhibition Restores Mitophagy and Alleviates Alzheimer's Disease Pathology

MedComm
Mitophagy is a conserved cellular process that removes dysfunctional or excess mitochondria. Increasing evidence suggests that impaired mitophagy plays a crucial role in AD development. Promoting mitophagy has been shown to be protective in models of AD,
Wensheng Li, Xuan Yu, Cuiping Guo, Yuting Huang, Zhen Wei, Yi Liu, Jian‐Zhi Wang, Rong Liu, Weike Ji, Qiuhong Duan, Jing Wang, Guihua Wang, Xiaochuan Wang   +12 more
doaj   +1 more source

Neuroprotective effect of an unsaturated mannuronate oligosaccharide derived from enzyme-degraded polymannuronate on an in vitro Parkinson's disease-like model

Journal of Agriculture and Food Research
This study mainly aimed to explore the intervention effect of an unsaturated mannuronate oligosaccharide (MOS) on Parkinson's disease (PD) and its potential mechanism at the cellular level.
Decheng Bi, Jinfeng Huang, Nanting Zhu, Jue Cao, Yan Wu, Lijun Yao, Xueying Ding, Jianyong Wu, Xu Cao, Xu Xu   +9 more
doaj   +1 more source

Additional file 8: of miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1)

, 2016
a Schematic diagram of miR-23a ~ 27a ~ 24–2 and miR-23b ~ 27b ~ 24–1 clusters. b, c The levels of miR-23a/b upon mitochondrial damages. HeLa cells were incubated with DMSO, 10 μM CCCP, or combination of 10 μM oligomycin and 4 μM antimycin as indicated. miR-23a/b levels were measured by qRT-PCR and normalized to corresponding U6 levels.
Kim, Jaekwang, Fiesel, Fabienne, Belmonte, Krystal, Hudec, Roman, Wang, Wang-Xia, Kim, Chaeyoung, Nelson, Peter, Springer, Wolfdieter, Kim, Jungsu   +8 more
openaire   +1 more source

Luteolin attenuates LPS-induced damage in IPEC-J2 cells by enhancing mitophagy via AMPK signaling pathway activation

Frontiers in Nutrition
BackgroundLuteolin (LUT), a flavonoid compound widely present in natural plants, has been extensively studied for its diverse biological properties, involving anti-inflammatory,antioxidant, anti-apoptosis and other properties.MethodsThe aim of this study
Jianyun Yuan, Ke Zhang, Lingling Yang, Xinyi Cheng, Jinyan Chen, Xiaoquan Guo, Huabin Cao, Caiying Zhang, Chenghong Xing, Guoliang Hu, Yu Zhuang   +10 more
doaj   +1 more source

Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.

PLoS Pathogens
Mitochondria, recognized as the "powerhouse" of cells, play a vital role in generating cellular energy through dynamic processes such as fission and fusion.
Zhe Sun, Zicheng Ma, Wandi Cao, Chenlong Jiang, Lei Guo, Kesen Liu, Yanni Gao, Juan Bai, Jiang Pi, Ping Jiang, Xing Liu   +10 more
doaj   +1 more source

Naringenin's rescue of broiler spleen from LPS-triggered pyroptosis and inflammation: Decoding the AMPK/PINK1/Parkin-driven mitophagy pathway

Poultry Science
Naringenin (Nar) is known to maintain mitochondrial homeostasis, antioxidation and anti-inflammation. Damaged mitochondria can promote excessive Reactive oxygen species (ROS) production, triggering pyroptosis and inflammation process in immune tissues ...
Yu Xia, Yidan Wang, Jiahui Xue, Jiahong Chu, Yanhe Zhang, Fuze She, Huijie Chen, Shu Li   +7 more
doaj   +1 more source

PTEN induced putative kinase 1 (PINK1) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source