Results 51 to 60 of about 223,608 (200)
PTEN: A master regulator of neuronal structure, function, and plasticity. [PDF]
, 2014 PTEN (phosphatase and tensin homolog on chromosome ten) is a dual protein/lipid phosphatase that dephosphorylates PIP3, thereby inhibiting the AKT/mTOR pathway. This inhibition ultimately decreases protein translation, cell proliferation and cell growth.
Garcia-Junco-Clemente, Pablo +1 more
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Neuropsychiatric Disease and Treatment, 2021 Xiaoli Ren,1 Zhiyun Wang,1 Congfang Guo2 1Department of Neurology, Tianjin First Central Hospital, Tianjin, 300192, People’s Republic of China; 2Department of Emergency, Tianjin First Central Hospital, Tianjin, 300192, People’s Republic of ...
Ren X, Wang Z, Guo C
doaj
Research Progress on PI3K/AKT/mTOR Signaling Pathway in Burkitt Lymphoma
Zhongliu Fangzhi Yanjiu, 2019 Burkitt lymphoma is a highly aggressive subtype of non-Hodgkin lymphoma. And it is one of the fastest growing human tumors. The lymphoma can be divided into three subclasses: endemic type, sporadic type and immunodeficiency-associated type, according to ...
SUN Yuanyuan, ZHANG Mingzhi
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MicroRNA-23a promotes myelination in the central nervous system. [PDF]
, 2013 Demyelinating disorders including leukodystrophies are devastating conditions that are still in need of better understanding, and both oligodendrocyte differentiation and myelin synthesis pathways are potential avenues for developing treatment ...
Fu, Ying-Hui +5 more
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The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer [PDF]
, 2020 According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further
Bratu, Ovidiu Gabriel +8 more
core +3 more sources
In vivo characterization of hippocampal electrophysiological processes in the heterozygous Pten knockout model of autism [PDF]
, 2018 While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism, little work has been done to demonstrate how corresponding in vitro physiological alterations in this model may underpin these cognitive deficits in ...
Barry, Jeremy +2 more
core +1 more source
USP13 serves as a tumor suppressor via the PTEN/AKT pathway in oral squamous cell carcinoma
Cancer Management and Research, 2019 Zhi Qu1, Ran Zhang2, Meng Su2, Weixian Liu1 1Department of Oral and Maxillofacial Surgery, Shengjing Hospital, China Medical University, Shenyang, China; 2Department of Prosthodontics, Second Affiliated Hospital ...
Qu Z, Zhang R, Su M, Liu W
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Di-san junyi daxue xuebao, 2021 Objective To determine the effect of DNAJC1 gene on the proliferation and apoptosis of multiple myeloma cell lines and preliminarily investigate its mechanism.
YANG Bihui +5 more
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Molecular landscape of borderline ovarian tumours: A systematic review
Open MedicineBorderline ovarian tumours (BOTs) show intriguing characteristics distinguishing them from other ovarian tumours. The aim of the systematic review was to analyse the spectrum of molecular changes found in BOTs and discuss their significance in the ...
Sadlecki Pawel +1 more
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Zhongliu Fangzhi Yanjiu, 2020 Objective To investigate the effect of miR-214 on the apoptosis of nasopharyngeal carcinoma (NPC) cells by regulating the activation of AKT signaling pathway through targeting PTEN.
HAN Jibo +4 more
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