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Journal of Organic Chemistry, 2022
The methods for modification of azoloannulated pteridines with (hetero)aromatic nucleophiles using a nucleophilic substitution of hydrogen (SNH) methodology have been developed in this work.
D. A. Gazizov +4 more
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The methods for modification of azoloannulated pteridines with (hetero)aromatic nucleophiles using a nucleophilic substitution of hydrogen (SNH) methodology have been developed in this work.
D. A. Gazizov +4 more
semanticscholar +1 more source
Тhio‐containing pteridines: Synthesis, modification, and biological activity
Archiv der Pharmazie, 2022The present article is devoted to searching for biologically active agents among novel thio‐containing pteridines. Synthetic protocols based on the condensation of 5,6‐diamino‐2‐thioxo‐2,3‐dihydropyrimidin‐4(1H)‐ones with dicarbonyl compounds were ...
M. S. Kazunin +7 more
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Polarographic Study of Pteridines
Journal of Pharmaceutical Sciences, 1966The electronegativity of the half-wave potentials of a series of pteridine congeners was found to be related to the substituent groups. The 2,4,7-triaminopteridines, 7-substituted 4-amino-2-aryl-6-pteridinecarboxarnides, and 4,7-diamino-2-aryl-6-pteridinecarboxamides were characterized, in that order, by decreasingly lower electronegative half-wave ...
M, Lapidus, M E, Rosenthale
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Pteridines and affective disorders
Acta Neuropsychiatrica, 2002The pteridine tetrahydrobiopterin (BH4) is an essential cofactor in the biosynthesis of dopamine, (nor)epinephrine, serotonin and nitric oxide (NO). Furthermore, BH4 has a direct influence on release mechanisms of these neurotransmitters and on serotonin receptor binding activityimmunology.
Hoekstra, R (Rosa), Fekkes, Durk
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Pteridine, XLI. Zur Synthese von Pteridin‐N‐8‐ribosiden
Chemische Berichte, 1971AbstractZur Synthese der ersten Pteridin‐N‐8‐riboside (912) werden 5‐Nitro‐4‐ribofuranosylamino‐pyrimidine (14) zunächst zu den 5‐Aminoderivaten (5, 6) reduziert, diese dann mit Glyoxyl‐säureester kondensiert (7, 8) und 7, 8 anschließend cyclisiert. Zur Charakterisierung der Produkte dienen UV‐ und NMR‐Spektren.
Hartmut Rokos, Wolfgang Pfleiderer
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Journal of the Chemical Society C: Organic, 1968
Pteridine-2-thiol was reduced by sodium borohydride to the 3,4-dihydro-derivative. Pteridine-2-thiol also reacted readily with sodium hydrogen sulphite and the following potentially carbanionic (‘Michael’) reagents; acetylacetone, ethyl acetoacetate, dimedone, and phloroglucinol.
Adrien Albert, John J. McCormack
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Pteridine-2-thiol was reduced by sodium borohydride to the 3,4-dihydro-derivative. Pteridine-2-thiol also reacted readily with sodium hydrogen sulphite and the following potentially carbanionic (‘Michael’) reagents; acetylacetone, ethyl acetoacetate, dimedone, and phloroglucinol.
Adrien Albert, John J. McCormack
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Pteridine, XVI. Zur Synthese und Struktur von Pteridin‐glykosiden
Chemische Berichte, 1962AbstractAusgehend von 2‐Amino‐4‐alkoxy‐7‐oxo‐dihydropteridinen wurden mit Halogenzuckern in siedendem Xylol und bei Gegenwart von Silbercarbonat Pteridin‐glykoside erhalten. Diese Produkte zeigen neben der erwarteten Säurelabilität der Glykosidbindung auch eine große Hydrolysenempfindlichkeit gegenüber Alkalien, was ebenso wie die UV ...
Wolfgang Pfleiderer, Rolf Lohrmann
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Nature, 1948
ALTHOUGH many derivatives of pteridine, both natural and synthetic, are known, the parent substance pteridine (I) does not appear to have been described. This substance has now been prepared by the condensation of 4 : 5-diaminopyrimidine with glyoxal bisulphite.
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ALTHOUGH many derivatives of pteridine, both natural and synthetic, are known, the parent substance pteridine (I) does not appear to have been described. This substance has now been prepared by the condensation of 4 : 5-diaminopyrimidine with glyoxal bisulphite.
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Pteridines. IX. Some pteridine isomers of triamterene
Journal of Medicinal Chemistry, 1968J, Weinstock, R Y, Dunoff
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