Results 61 to 70 of about 8,395 (249)

Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin [PDF]

, 2017
In the vasculature, a physiologic production of nitric oxide (NO) is maintained by endothelial nitric oxide synthase (eNOS). Induction of inducible nitric oxide synthase (ÍNOS) under inflammatory conditions (e.g. septic shock) resulting in high levels of
Linscheid, Philippe, Mueller, Nicolas J., Schaffner, Andreas, Schoedon, Gabriele, Walter, Roland Β.   +4 more
core  

Synthesis of 6-Hydroxymethylpterin α- and β-D-Glucosides [PDF]

, 2010
The key precursor, N(2)-(N,N-dimethylaminomethylene)-6-hydroxymethyl-3-[2-(4-nitrophenyl)ethyl]pterin (11) was efficiently prepared from 2,5,6-triamino-4-hydroxypyrimidine (8) in 5 steps.
Baba, Hiroki, Ejiri, Kazumasa, Hanaya, Tadashi, Yamamoto, Hiroshi   +3 more
core   +1 more source

Mutationen im PTS-Gen und mögliche Auswirkungen auf Funktion und Struktur der 6-Pyruvoyl-Tetrahydropterin-Synthase [PDF]

, 2002
Background: Research on Juvenile Idiopathic Arthritis (JIA) should support patients, caregivers/parents (carers) and clinicians to make important decisions in the consulting room and eventually to improve the lives of patients with JIA.
Preuße, Friedrich-Alexander, Prof. Dr. O. Bandmann   +1 more
core   +9 more sources

A Twenty Year Association with Pteridines - Chemistry, Biochemistry and Molecular Biology

Pteridines, 1998
The author has summarised the science in his published works which contained chemistry. biochemistry and molecular biology related to pteridines as a dedication to Professor Wolfgang Pfleiderer on the occasion of his seventieth birthday.
Armarego Wilfred L. F.
doaj   +1 more source

Applications of QSPR and Machine Learning in Molecular Photonics

Advanced Optical Materials, Volume 13, Issue 33, November 25, 2025.
Quantitative structureproperty relationships (QSPR) and machine learning (ML) are transforming photochemistry by enabling pre‐synthetic screening of photoactive molecules. This review outlines advances in data‐driven discovery of optical materials and functional dyes, identifies effective descriptors and models for photophysical processes, and provides
Andrey A. Buglak, Platon P. Chebotaev, Mikhail A. Filatov   +2 more
wiley   +1 more source

An Allele of Glutamate Formiminotransferase Triggers 5‐Methyl‐Tetrahydrofolate‐to‐MeFox Conversion and Facilitates Folate Biofortification in Maize

Advanced Science, Volume 12, Issue 42, November 13, 2025.
This work demonstrates the distinct roles of the glutamate formiminotransferase (GFT) enzyme in plants. The GFT triggers the conversion of 5‐methyl‐tetrahydrofolate to MeFox in plants, a process distinct from its role as a formiminotransferase in mammals.
Tong Lian, Wenzhu Guo, Yanjing Wang, Weiwei Wen, Weixuan Wang, Ling Jiang, Qiuju Liang, Ji'an Liu, Haijun Liu, Yuan Xue, Lixu Pan, Qiaoquan Liu, Ping Yin, Delin Zhang, Jianbing Yan, Chunyi Zhang   +15 more
wiley   +1 more source

Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]

, 2011
Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin, Kunuthur, S. P., Milliken, P. H., Suckling, C. J., Wadsworth, R. M.   +4 more
core   +1 more source

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source

A Modified Microbiological Method for Determination of Folate Levels in Erythrocyte and Plasma

Pteridines, 2007
Pteridines are natural heterocyclic compounds and they are generally divided into two main groups which are denominated as conjugated and unconjugated pteridines.
Sipahi Hande, Baydar Terken, Ozalp Meral, Sahin Gonul   +3 more
doaj   +1 more source

The Role of Neopterin and Interleukin‐6 Detection in Saliva and Plasma in Oral and Oropharyngeal Cancer Patients: A Prospective Study

Clinical and Experimental Dental Research, Volume 11, Issue 5, October 2025.
ABSTRACT Objectives The incidence of oral and oropharyngeal cancer is continually rising and affects increasingly younger patients. Consequently, many studies focus on early diagnosis using appropriate biomarkers. Neopterin and interleukin‐6 (IL‐6) are promising predictive and prognostic markers of immune response activation, both systemic and local ...
Lenka Šašková, Peter Tvrdý, Bohuslav Melichar, Josef Tomandl, Jana Zapletalová, Michal Mozol'a, Petr Michl, David Král, Richard Pink   +8 more
wiley   +1 more source