Results 41 to 50 of about 3,922 (190)

Pyridyl‐Thiazole‐Thiosemicarbazones as Antitrypanosomatidae Agents: Design, Synthesis, and In Silico Profiling

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A novel pyridine–thiazole derivative, Compound 8, exhibited potent dual antitrypanosomatid activity. It demonstrated remarkable in vitro efficacy against Trypanosoma cruzi (IC50 = 1.0 µM) and L. amazonensis (IC50 = 3.9 µM). Molecular docking studies suggested interactions with heme and multiple molecular targets.
Anderson José Firmino Santos da Silva, Daiane Santiago da Cruz Olimpio, Lucas Manoel da Silva Sousa, Graziella Leite Brondani, Tacylla Lima Silva, Wéllyda Belmira de Lira Silva, Natáli Tereza Capistrano Costa, Marcelo Zaldini Hernandes, Policarpo Ademar Sales Junior, Valéria Rêgo Alves Pereira, Ana Cristina Lima Leite   +10 more
wiley   +1 more source

From o‐Phenylenediamine to Flavin Derivatives: A Potential Prebiotic Carbon Skeleton Expansion With Formaldehyde, Cyanide, and CO2

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A Strecker‐type reaction of aromatic ortho‐diamines with various aldehydes and cyanide assembles the bicyclic amidine core of flavin‐derived heterocycles under mild conditions. Subsequent oxidation, radical or photochemical cyanation, carboxylation with CO2, and CO2‐mediated cyclization build the three‐ring alloxazine scaffold. This sequence provides a
Christian Held, Rodrigo José da Silva Lima, Ji‐Woong Lee   +2 more
wiley   +1 more source

Control Strategies in Guanine Biocrystallization

Angewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Biological guanine crystals produce spectacular photonic phenomena in animals and hold great promise as new, sustainable optical materials. We review how organisms precisely control the structure, morphologies, and resulting optical properties of these crystals using a set of ingenious ‘design’ strategies, including control of pH, template‐directed ...
Shashanka S. Indri, Avital Wagner, Benjamin A. Palmer   +2 more
wiley   +2 more sources

Evaluation of Serum and Urinary Levels of some Pteridine Pathway Components in Healthy Turkish Children

Pteridines, 2012
Neopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response.
Girgin Gözde, Baydar Terken, Fuchs Dietmar, Sahin Gönül, Özmert Elif, Yurdakök Kadriye   +5 more
doaj   +1 more source

Pteridines in the Control of Pigmentation

Journal of Investigative Dermatology, 1997
The influence of UVB irradiation on the metabolic pathway for the production of L-tyrosine from L-phenylalanine in the human epidermis has been examined in 12 healthy volunteers with photo skin types I-VI (Fitzpatrick classification). This metabolic pathway involves the induction of GTP-cyclohydrolase 1 (GTP-CH-1), the rate-limiting enzyme for de novo ...
Schallreuter, Karin U., Schulz-Douglas, Vincent, Bünz, Andreas, Beazley, Wayne, Körner, Christa   +4 more
openaire   +2 more sources

Acral Melanocytic Lesions Under Conventional, Sub‐Ultraviolet Reflectance, and Ultraviolet‐Induced Fluorescence Dermoscopy: A Comparative Analysis

International Journal of Dermatology, Volume 65, Issue 8, Page 1625-1632, August 2026.
Conventional dermoscopy provided higher scores than ultraviolet‐induced fluorescence dermoscopy for parallel furrow pattern, parallel ridge pattern (PRP), fibrillar pattern, dots/clods, radial lines, blue–white structureless areas and blotch, and outperformed sub‐ultraviolet reflectance dermoscopy (sUVRD) for PRP and blue–white structureless areas ...
Handan Merve Erol Mart, Ahmet Taha Aydemir, Pawel Pietkiewicz, Bengu Nisa Akay   +3 more
wiley   +1 more source

Electronic Structure of Tetrahydropteridine Derivatives

Pteridines, 1999
Recently; the 4-amino analogue of tetrahydrobiopterin was found to be a strong inhibitor of nitric oxide synthase while being bound to the enzyme in a manner similar to the natural cofactor tetrahydrobiopterin.
Reibnegger Gilbert, Pauschenwein Jutta, Werner Ernst R.   +2 more
doaj   +1 more source

Reconfiguring biofortification strategies to transform food systems and address micronutrient deficiency of the 21st century

Journal of Integrative Plant Biology, Volume 68, Issue 8, Page 2511-2547, August 2026.
This review explores how to make staple foods and horticultural crops more nutritious, including how artificial intelligence‐based screening of gene banks helps deploy nutritionally rich germplasm into breeding. Genome editing can help develop crops richer in minerals, vitamins, and health‐promoting compounds, supporting healthier diets and more ...
Rhowell Jr. N. Tiozon, Alisdair R. Fernie, Nese Sreenivasulu   +2 more
wiley   +1 more source

Alternative cancer therapy through modeling pteridines photosensitizer quantum yield singlet oxygen production using swarm-based support vector regression and extreme learning machine

Cogent Engineering
Photodynamic cancer therapy circumvents the major side effects associated with the conventional cancer treatment methods, such as chemotherapy, surgery and exposure to radiation.
Nahier Aldhafferi
doaj   +1 more source

Pterin function in bacteria

Pteridines, 2017
Pterins are widely conserved biomolecules that play essential roles in diverse organisms. First described as enzymatic cofactors in eukaryotic systems, bacterial pterins were discovered in cyanobacteria soon after.
Feirer Nathan, Fuqua Clay
doaj   +1 more source