Results 41 to 50 of about 3,589 (204)
This review explores how to make staple foods and horticultural crops more nutritious, including how artificial intelligence‐based screening of gene banks helps deploy nutritionally rich germplasm into breeding. Genome editing can help develop crops richer in minerals, vitamins, and health‐promoting compounds, supporting healthier diets and more ...
Rhowell Jr. N. Tiozon +2 more
wiley +1 more source
Pteridines in the Control of Pigmentation
The influence of UVB irradiation on the metabolic pathway for the production of L-tyrosine from L-phenylalanine in the human epidermis has been examined in 12 healthy volunteers with photo skin types I-VI (Fitzpatrick classification). This metabolic pathway involves the induction of GTP-cyclohydrolase 1 (GTP-CH-1), the rate-limiting enzyme for de novo ...
Schallreuter, Karin U. +4 more
openaire +2 more sources
The diversity-oriented synthesis of pteridines—achievements and potential for development
The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines.
Suckling, Colin
core +1 more source
Chemotherapy of malaria. Part VIII. Synthesis of uracils, thiouracils, pteridines and thiopteridines [PDF]
Twenty-two pteridines of formula (I) and twenty-one thiopteridines of formula (II) have been synthesisedvia 4-aminouracils and 4:5-diaminouracils for assessing their antimalarial and antibacterial ...
Palande, B. N., Ganapathi, K.
core +1 more source
Capture‐SELEX of DNA Aptamers for Highly Selective Binding of Folate
Using capture‐SELEX, a DNA aptamer with sub‐micromolar affinity for folate was isolated, showing excellent selectivity. Using this aptamer, a light‐up fluorescent biosensor was developed for folate detection. Folate (vitamin B9) is an essential micronutrient for human health, particularly during pregnancy.
Yachen Xie, Yifan Chen, Juewen Liu
wiley +1 more source
Daily Variation and Effect of Dietary Folate on Urinary Pteridines
Introduction: Urinary pteridines are putative molecular biomarkers for noninvasive cancer screening and prognostication. Central to their translational biomarker development is the need to understand the sources and extent of their non-epidemiological ...
Shi, Honglan +5 more
core +1 more source
This study integrated bioinformatics analysis, cellular models, and PD/constipation mouse models to identify SHMT2 as a key shared biomarker linking Parkinson's disease and constipation. SHMT2 upregulation was validated in dopaminergic neurons and the enteric nervous system, highlighting its potential role in gut–brain axis dysfunction.
Jiehua Su +10 more
wiley +1 more source
In this study, we tested whether white and yellow morphs of the common wall lizard (Podarcis muralis) adopt alternative strategies shaped by the immuno‐competence handicap hypotheses (ICHH). We found that testosterone‐induced immune suppression was stronger in white males, while aggression decreased in both morphs.
Roberto Sacchi +5 more
wiley +1 more source
Alloxazine photosensitizers, molecularly engineered through sugar conjugation and methoxy substitution to enhance solubility, photodynamic potency, and fluorescence, enable image‐guided photodynamic therapy while inhibiting cancer cell growth in the absence of photoactivation.
Rubej R. Khan +7 more
wiley +1 more source
Neopterin, as a non-conjugated pteridine, is synthesized from guanosine triphosphate and its production is upregulated upon the activation of cellular immune response.
Girgin Gözde +5 more
doaj +1 more source

