Results 31 to 40 of about 3,953 (191)
A traceless solid-phase synthesis of pteridines
, 2003 The linking of pyrimidines to polystyrene supports via either a 2- or 4-thioether provides access to pteridines through solid-phase synthesis. Oxidative cleavage (dimethyldioxirane) followed by nucleophilic substitution by amines, azide, or water ...
La Rosa, S. +2 more
core +4 more sources
In silico and in vivo screening of triamterene synthetic analogues as promising diuretics
Medičnì Perspektivi, 2022 The modification of lead-compound aimed to the increasing of activity, decrement of toxicity or improvement of selectivity is one of the most important methods used for elaboration of novel medications.
K.V. Sokolova +4 more
doaj +1 more source
Acral Melanocytic Lesions Under Conventional, Sub-Ultraviolet Reflectance, and Ultraviolet-Induced Fluorescence Dermoscopy: A Comparative Analysis. [PDF]
Int J DermatolConventional dermoscopy provided higher scores than ultraviolet‐induced fluorescence dermoscopy for parallel furrow pattern, parallel ridge pattern (PRP), fibrillar pattern, dots/clods, radial lines, blue–white structureless areas and blotch, and outperformed sub‐ultraviolet reflectance dermoscopy (sUVRD) for PRP and blue–white structureless areas ...
Mart HME +3 more
europepmc +2 more sources
A Complete Telomere-To-Telomere Assembly of <i>Plectropomus leopardus</i> and Phylogenomic Insights Into Perciformes. [PDF]
Evol ApplABSTRACT The leopard coral grouper, Plectropomus leopardus Lacepède, 1802, is an ecologically and economically important species in the family Epinephelidae. However, the absence of a complete reference genome has impeded advanced genetic research on this species, and the phylogenetic position of Epinephelidae within Perciformes remains unresolved ...
Zhao B +8 more
europepmc +2 more sources
The diversity-oriented synthesis of pteridines—achievements and potential for development
, 2013 The importance of pteridines in the key cofactors, tetrahydrofolate and tetrahydrobiopterin, has encouraged the development of the chemistry and chemical biology of pteridines.
Suckling, Colin
core +4 more sources
Pteridines, 2017 Conjugated and unconjugated pteridines and their derivatives are important cofactors in cellular metabolism. Hence, the amount of unconjugated pteridines in biological fluids has been found to be modified as a result of several disorders. It is necessary
Espinosa-Mansilla Anunciación +1 more
doaj +1 more source
Beyond the Classics: The Synergy of AI and Genomics Reveals an Expanded Repertoire of Pigmentation Genes. [PDF]
J Exp Zool B Mol Dev EvolClassical approaches for coloration analysis are limited by human low‐resolution phenotyping and genetic analysis. Artificial intelligence allows us to find genes beyond the tip of the iceberg that explain color and pattern diversity in nature. ABSTRACT Pigmentation has long served as a powerful system for exploring gene–trait relationships, yet much ...
Ahi EP, Karagic N.
europepmc +2 more sources
Pharmaceuticals, 2023 Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (4, 5a–c, 6a,b), 5-arylethylidene-amino-2-thiopyrimidine-4-ones (7,8), and 6-arylpteridines (9,10) as dual ...
Samar El-Kalyoubi +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources
Allergology International, 2019 Background: Pteridines are metabolites of tetrahydrobiopterin, which serves as co-enzyme of nitric oxide synthase. We sought to investigate the usefulness of pteridines as biomarkers for childhood asthma control.
Saki Kasuga +10 more
doaj +1 more source