Drug resistance in B and non-B subtypes amongst subjects recently diagnosed as primary/recent or chronic HIV-infected over the period 2013–2016: Impact on susceptibility to first-line strategies including integrase strand-transfer inhibitors [PDF]
, 2017 Objectives To characterize the prevalence of transmitted drug resistance mutations (TDRMs) by plasma analysis of 750 patients at the time of HIV diagnosis from January 1, 2013 to November 16, 2016 in the Veneto region (Italy), where all drugs included in
Alvarez, M +18 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Analyzing the role of ACE2, AR, MX1 and TMPRSS2 genetic markers for COVID-19 severity
Human Genomics, 2023 Background The use of molecular biomarkers for COVID-19 remains unconclusive. The application of a molecular biomarker in combination with clinical ones that could help classifying aggressive patients in first steps of the disease could help clinician ...
Silvia Martinez-Diz +10 more
doaj +1 more source
The role of the N-acetylglucosamine phosphoenolpyruvate phosphotransferase system from Lactobacillus plantarum 8014 in the mechanism of action of glycocin F : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University, Manawatū, New Zealand [PDF]
, 2017 The rise in antibiotic-resistant bacteria is becoming a severe public health problem because of the shortage of new antibiotics to combat existing resistant bacterial pathogens.
Bailie, Marc Alex
core
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma
Frontiers in Immunology, 2022 Autologous T cells expressing the Chimeric Antigen Receptor (CAR) have been approved as advanced therapy medicinal products (ATMPs) against several hematological malignancies.
Noelia Maldonado-Pérez +22 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Representation of "Disease" by mothers of adolescent childhood cancer survivors
Психология и Психотерапия Семьи, 2018 To describe representations of "disease" in families with adolescent childhood cancer survivors. Method: Participants were 8 mothers with experience of encounter of childhood cancer and 7 mothers without it. They chose one picture from TAT as association
Julia Bykhovets, Phd, Lina Kogan-Lerner
doaj
Mitigating gas migration with eutectic bismuth alloy plugs
Petroleum ResearchGas migration is an important concern to address in oil wells, especially in those that are to be abandoned. Stopping a gas leakage is not a simple task, and this can be particularly detrimental when setting a cement plug, as the migrated gas can ...
Lewaa Hmadeh +4 more
doaj +1 more source
Potential of the Other Genetic Information Coded by the Viral RNA Genomes as Antiviral Target
Pharmaceuticals, 2019 In addition to the protein coding information, viral RNA genomes code functional information in structurally conserved units termed functional RNA domains.
Alfredo Berzal-Herranz +3 more
doaj +1 more source