Results 91 to 100 of about 24,819 (234)

Genetic Regulation of Puberty Timing in Humans. [PDF]

, 2015
Understanding the regulation of puberty timing has relevance to developmental and human biology and to the pathogenesis of various diseases. Recent large-scale genome-wide association studies on puberty timing and adult height, body mass index (BMI) and ...
Day, Felix R, Ong, Ken K, Perry, John RB
core   +2 more sources

Management of precocious puberty [PDF]

International Journal of Pediatric Endocrinology, 2013
The objectives of treatment for children with central precocious puberty (CPP) are to avoid psychosocial problems caused by early pubertal development and to normalize adult height (AH). A long-acting GnRH analog is the treatment of choice for CPP.
openaire   +2 more sources

An International ASXL3 Natural History Study: Deep Phenotypic Analyses Including Detailed Reports of a Milder Phenotype, Novel Associations, and Clinical Recommendations

American Journal of Medical Genetics Part A, Volume 197, Issue 11, November 2025.
ABSTRACT Natural History Studies can help inform clinician and caregiver expectations, form the basis of management guidelines, and provide a comparator for therapeutic intervention. In rare conditions, where collection of prospective longitudinal data is untimely and impractical, quasi‐natural history data—from multiple individuals of different ages ...
E. Woods, N. Holmes, A. S. Denommé‐Pichon, M. Vincent, N. Belova, C. Gooch, B. Isidor, C. W. Ockeloen, E. Pavlidou, H. Stewart, V. J. M. Verhoeven, A. Ververi, A. Dixit, A. Sarkar, R. Legg, E. Reid, M. Balasubramanian   +16 more
wiley   +1 more source

Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy [PDF]

, 2002
We studied bone mineral density (BMD), bone metabolism, and body composition in 47 children with central precocious puberty (n = 36) or early puberty (n = 11) before, during, and after cessation of GnRH agonist.
Boot, A.M. (Annemieke), Drop, S.L.S. (Stenvert), Krenning, E.P. (Eric), Muinck Keizer-Schrama, S.M.P.F. (Sabine) de, Sluis, I.M. (Inge) van der   +4 more
core  

Endocrine disruptors and abnormalities of pubertal development [PDF]

, 2008
Onset and development of puberty is regulated by the neuroendocrine system. Population-based studies worldwide have observed secular trends towards earlier puberty development. These changes are apparently caused by environmental factors such as improved
Adair, Adair, Berg-Kelly, Blanck, Colon, DeCastro, Den Hond, Den Hond, Dunger, Gamba, Gladen, Gore, Grumbach, Guo, Hertz-Picciotto, Ibanez, Kaya, Klein, Krstevska-Konstantinova, Kubo, Kuhl, Lebrethon, Lee, Legler, Levine, Levy, Lewis, Marshall, Marshall, McKee, McLachlan, Mol, Naftolin, Ohtake, Parent, Patton, Petroff, Proos, Ramirez, Rasier, Rockett, Roselli, Rubin, Safe, Sagiv, Saiyed, Selevan, Singh, Skynner, Staessen, Styne, Teilmann, Tena-Sempere, Tena-Sempere, Terasawa, Traggiai, Vasiliu, Vinggaard, Wade, Warner, Wu, Wu, Zeinoaldini   +62 more
core   +2 more sources

Bone Mineral Accrual From Adolescence Into Young Adulthood and Peak Bone Mass: A Longitudinal Cohort Study

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims Understanding bone mass accumulation patterns and factors influencing them during growth is important for preventing osteoporosis later in life. This study investigated longitudinal changes in bone mineral content (BMC), bone mineral density (BMD), and bone mineral apparent density (BMAD) during growth, with the aim of ...
Arzhang Naseri, Farnaz Atighi, Alireza Keshtkar, Pedram Talezadeh, Marzieh Bakhshayeshkaram, Marjan Jeddi, Mohammad Mahdi Dabbaghmanesh, Seyed Taghi Heydari, Naeimehossadat Asmarian, Mohammad Hossein Dabbaghmanesh   +9 more
wiley   +1 more source

Elevating and empowering reproductive futures: Pediatric and adolescent gynecology's specialized care across the globe

International Journal of Gynecology &Obstetrics, Volume 171, Issue 2, Page 528-537, November 2025.
Abstract Pediatric and adolescent gynecology (PAG) is an expanding subspecialty of obstetrics and gynecology that addresses the reproductive health needs of girls and young women worldwide. In regions with limited subspecialist healthcare providers, general obstetricians, gynecologists, and nurse‐midwives, frontline healthcare providers provide ...
Nichole A. Tyson, Méabh Ní Bhuinneáin, Hema Divakar, Lauren Mauger, Judith Simms Cendan, Marisa Labovsky, FIGO Committee on Adolescent and Youth Health   +6 more
wiley   +1 more source

Juvenile granulosa cell tumor in a nine year old

Journal of Pediatric Surgery Case Reports, 2020
Pediatric granulosa cell tumors of the ovary are rare functional neoplasms causing secondary precocious puberty. The tumor possesses significant diagnostic challenge when occurs in a patient approaching puberty due to masking of symptoms.
Syed Waqas Ali, Nouman Nawaz Ali, M. Sajjad Ashraf, Muhammad Arif Mateen Khan, Muhammad Usman Tariq   +4 more
doaj   +1 more source

Trajectory and Trend of Weight Status, Emotional Wellbeing and Sleep From Infancy to Childhood to Adolescence in Scotland: An Analysis of Growing up in Scotland Birth Cohort 1

Pediatric Obesity, Volume 20, Issue 11, November 2025.
ABSTRACT Background Childhood obesity interventions often overlook sleep and emotional wellbeing, though research shows both are associated with weight status across childhood. The timing of their co‐development and the most effective point for intervention remain poorly understood. The aim of this study was to examine the trajectories of sleep, weight
Emma Louise Gale, Joanne Elizabeth Cecil, Andrew James Williams   +2 more
wiley   +1 more source

Teratoid Hepatoblastoma: Clinicopathologic Features and Outcomes

Pediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Background Teratoid hepatoblastoma (HB) is a rare histologic subtype of the most common pediatric liver cancer. Understanding of the clinicopathologic features and outcomes of patients with this disease is currently limited. Methods Multi‐institution, retrospective chart review was conducted to compare 20 children with teratoid HB to 129 ...
Brian T. Hickner, Andres F. Espinoza, Soo Jin Cho, Stephen Sarabia, Martin Urbicain, Ann Wang, Sanjeev A. Vasudevan, Dolores H. López‐Terrada, Kalyani R. Patel   +8 more
wiley   +1 more source