Results 71 to 80 of about 3,391,421 (303)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Rancang Bangun Alat Elliptical trainer Outdoor

Mekanika, 2020
The placement of outdoor fitness equipment at tourist attractions is one of the attractions for tourists. Besides that, it can also be used as a means of health socialization for the community in public places. The elliptical trainer type air walker is a
Zainal Arifin, Singgih Dwi Prasetyo, Suyitno Suyitno, Dominicus Danardono Dwi Prija Tjahjana, Rendy Adhi Rachmanto, Wibawa Endra Juwana, Chico Hermanu B. Apribowo, Trismawati Trismawati   +7 more
doaj   +1 more source

Competition and cost overruns in procurement [PDF]

Most cases of cost overruns in public procurement are related to important changes in the initial project design. This paper deals with the problem of design speciffication in public procurement and provides a rationale for design misspeciffication.
Juan José Ganuza
core  

Engaging with a healthy tourism “offer”: strategies to improve place perceptions [PDF]

, 2017
The purpose of this paper is to explore how engagement with a healthy tourism “offer” could improve place perceptions through the development of collaborative strategies to promote a wellbeing destination. Design/methodology/approach – This paper takes a
Ann Hemingway, ISCA/Cebr, Local Government Improvement and Development, Mintel, Stacy Wall, Susanna Curtin   +5 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Place centric design of public displays for libraries

, 2021
Public libraries are lively third places welcoming people from all levels of society. In addition to offering extensive collections of documents, they host a wide range of events: from public readings, clubs, to hands-on participatory activities. Each of these events sparks the curation and creation of a variety of content by librarians and patrons ...
openaire   +1 more source

Public design of digital commons in urban places: A case study

International Journal of Human-Computer Studies, 2015
This paper can be framed within the growing interest in the public dimension of technology design: it proposes a framework for the public design of urban technologies by elaborating on the concepts of digital commons, matters of concerns and engagement. The framework is discussed through the case study of a mobility application developed within a wider
Teli, Maurizio, Bordin, Silvia, Menendez Blanco, Maria, Orabona, Giusi, De Angeli, Antonella   +4 more
openaire   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

The built environment and place attachment: Insights from Japanese cities

Preventive Medicine Reports
Objective: Place attachment plays an important role in individuals' health and well-being. Understanding the associations between urban design attributes and place attachment can inform strategies to promote place attachment.
Jiuling Li, Mohammad Javad Koohsari, Andrew T. Kaczynski, Ryo Tanimoto, Reo Watanabe, Tomoki Nakaya, Yufeng Luo, Jing Zhao, Akitomo Yasunaga, Koichiro Oka, Tomoya Hanibuchi   +10 more
doaj   +1 more source

Introducing Design Thinking in Social Innovation and in the Public Sector: a design based learning framework

European Public & Social Innovation Review, 2017
Design Thinking (DT) is becoming a mantra in the different areas of innovation: including SI and Public sector (Manzini&Rizzo, 2011; Deserti&Rizzo, 2015).
Francesca Rizzo,, Alessandro Deserti, , Onur Cobanli   +2 more
doaj   +1 more source