Results 101 to 110 of about 636,686 (304)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Informal public transport modes in India: A case study of five city regions

IATSS Research, 2016
Traditionally, the provision of public transport is considered to be government's responsibility. Due to resource and capacity constraints in developing countries, however, government-provided public transport is often inadequate; it is the privately ...
Megha Kumar, Seema Singh, Akshima T. Ghate, Sarbojit Pal, Sangeetha Ann Wilson   +4 more
doaj   +1 more source

The principles of public transport network planning: a review of the emerging literature with select examples [PDF]

, 2011
This paper highlights for urban planners the key strategies and tactics that can be deployed to improve suburban public transport networks. Introduction The governance and management of public transport systems is an essential component of metropolitan
John Stone, Matthew Burke, Jago Dodson, Paul Mees   +3 more
core  

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Handling social considerations and the needs of different groups in public transport planning: a review of definitions, methods, and knowledge gaps

European Transport Research Review
This paper analyses the integration of social considerations into public transport planning. It addresses the challenge of balancing social benefits against objectives such as efficiency and cost minimization.
Robert Hrelja, Lena Levin, Rosalia Camporeale   +2 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Exploring shared e-scooter trip patterns and links to public transport service level

Multimodal Transportation
This paper explores how public transport and shared e-scooter travel interact. Trip end travel patterns of shared e-scooter users are explored in relation to Public Transport service levels. An index measuring transit service level is developed.
Graham Currie, Alexa Delbosc, Ryan Cox, Mahesha Jayawardhena, James Reynolds   +4 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Public transport subsidies and affordability in Mumbai, India [PDF]

This paper describes the role of public transport and the nature and incidence of transport subsidies in Mumbai, India. Mumbai has an extensive rail and bus network, and public transport is used for over 75 percent of all motorized trips in Greater ...
Cropper, Maureen, Bhattacharya, Soma
core