Results 11 to 20 of about 1,420,968 (272)
External evaluation of published population pharmacokinetic models of posaconazole
Frontiers in Pharmacology, 2022 Population pharmacokinetic (PopPK) models of posaconazole have been established to promote the precision dosing. However, the performance of these models extrapolated to other centers has not been evaluated.
Shuqi Huang +9 more
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Journal of Global Antimicrobial Resistance, 2023 : Objectives: Several linezolid population pharmacokinetic (popPK) models have been established to facilitate optimal therapy; however, their extrapolated predictive performance to other clinical sites is unknown. This study aimed to externally evaluate
Yan Qin +7 more
doaj +5 more sources
The external validity of published randomized controlled trials in primary care [PDF]
BMC Family Practice, 2009 Background A criticism of Randomized Controlled Trials (RCTs) in primary care is that they lack external validity, participants being unrepresentative of the wider population.
Montgomery Alan A +4 more
doaj +6 more sources
Internal and External Evaluation of the Book Principles and Methodology of Translation Published by SAMT [PDF]
پژوهشنامۀ انتقادی متون و برنامههای علوم انسانی, 2021 The present research aimed at analyzing the book Principles and Methodology of Translation in terms of its formal characteristics, content, and methodology, using the critical library research method in general and McDonough, Shaw, and Masuhara’s (2013 ...
Alireza Rasti
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Systematic external evaluation of published population pharmacokinetic models for tacrolimus in adult liver transplant recipients [PDF]
European Journal of Pharmaceutical Sciences, 2020 Background:Diverse tacrolimus population pharmacokinetic models in adult liver transplant recipients have been established to describe the PK characteristics of tacrolimus in the last two decades. However, their extrapolated predictive performance remains unclear.Therefore,in this study,we aimed to evaluate their external predictability and identify ...
Xiaojun Cai +2 more
exaly +5 more sources
Comparing postoperative complications of internal versus external fixation for closed diaphyseal tibial fractures in cats [PDF]
Veterinary EvidencePICO Question In cats with closed diaphyseal tibial fractures, does internal fixation, when compared to external fixation, result in a lower postoperative complication rate? Clinical bottom line Category of research Treatment.
Stephen Keith John, Jake Chitty
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External evaluation of published population pharmacokinetic models of tacrolimus in adult renal transplant recipients [PDF]
British Journal of Clinical Pharmacology, 2016 AimSeveral tacrolimus population pharmacokinetic models in adult renal transplant recipients have been established to facilitate dose individualization. However, their applicability when extrapolated to other clinical centres is not clear. This study aimed to (1) evaluate model external predictability and (2) analyze potential influencing factors ...
Zheng Jiao, Junjun Mao
exaly +3 more sources
External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings [PDF]
British Journal of Clinical Pharmacology, 2013 AimsVancomycin is one of the most evaluated antibiotics in neonates using modeling and simulation approaches. However no clear consensus on optimal dosing has been achieved. The objective of the present study was to perform an external evaluation of published models, in order to test their predictive performances in an independent dataset and to ...
Karel Allegaert +2 more
exaly +6 more sources
Pharmaceutics, 2023 Apixaban and rivaroxaban have first-line use for many patients needing anticoagulation for venous thromboembolism (VTE). The pharmacokinetics of these drugs in non-obese subjects have been extensively studied, and, while changes in pharmacokinetics have ...
Cyril Leven +6 more
doaj +3 more sources
Drug Design, Development and TherapyKeyu Yan,1 Xi Xie,2 Qing Shao,1 Na Wang,1 Miaomiao Yang1 1Department of Pharmacy, Xi’an Mental Health Center, Xi’an, Shaanxi, People’s Republic of China; 2Department of Clinical Laboratory, Hunan Prevention and Treatment Institute for Occupational ...
Yan K, Xie X, Shao Q, Wang N, Yang M
doaj +3 more sources