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Journal of Pharmacy and Pharmacology, 2010 AbstractObjectivesThe aim was to investigate the pharmacokinetic interaction between puerarin and edaravone, and the effect of borneol on the brain distribution kinetics of puerarin in rats.MethodsA reversed-phase high performance liquid chromatography method was developed and validated for the simultaneous determination of puerarin and edaravone in ...
Ming Xue
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In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase
Carbohydrate Research, 2004Puerarin (daidzein 8-C-glucoside), the most abundant isoflavone in Puerariae radix, is prescribed to treat coronary heart disease, cardiac infarction, problems in ocular blood flow, sudden deafness, and alcoholism. However, puerarin cannot be given by injection due to its low solubility in water.
Cheon-Seok Park
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Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis
Chemico-Biological Interactions, 2011Adverse drug reactions (ADR), especially intravenous hemolysis, have largely limited the application of puerarin injections in clinics. This study investigated the underlying mechanisms of puerarin-induced hemolysis. Our results show that puerarin induced concentration-dependent and time-dependent hemolysis when human erythrocytes were incubated in ...
Zi-Ren Su, Hua Zhou, Xiao-Ping Lai
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Drug Development and Industrial Pharmacy, 2006
Puerarin is a potential therapeutic agent for cardiovascular diseases. But its poor oral bioavailability restricts its clinical application. In present study, as an evaluation of a formulation to improve the bioavailability of the drug, puerarin and its phospholipid complex were given to rats by intragastrically (i.g.) administration to compare ...
A S C Chan
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Puerarin is a potential therapeutic agent for cardiovascular diseases. But its poor oral bioavailability restricts its clinical application. In present study, as an evaluation of a formulation to improve the bioavailability of the drug, puerarin and its phospholipid complex were given to rats by intragastrically (i.g.) administration to compare ...
A S C Chan
exaly +3 more sources
Cochrane Database of Systematic Reviews, 2016
Puerarin, a form of herbal medicine, is widely used in the treatment of ischaemic stroke in China.To assess the effects of puerarin in people with ischaemic stroke.We searched the Cochrane Stroke Group Trials Register and the Chinese Stroke Trials Register (last searched August 2015). In addition, we searched the Cochrane Central Register of Controlled
Bian, Liu +3 more
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Puerarin, a form of herbal medicine, is widely used in the treatment of ischaemic stroke in China.To assess the effects of puerarin in people with ischaemic stroke.We searched the Cochrane Stroke Group Trials Register and the Chinese Stroke Trials Register (last searched August 2015). In addition, we searched the Cochrane Central Register of Controlled
Bian, Liu +3 more
openaire +2 more sources
A Supramolecular Hydrogel of Puerarin
Journal of Biomedical Nanotechnology, 2018Supramolecular hydrogels have drawn increased attention because of their advantages in facile synthesis, biocompatibility, easy degradation and fast responses to external stimuli. Until now, the example of hydrogelators of pure natural resources has rarely been reported.
Yanbin, Cai +8 more
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Applied Microbiology and Biotechnology, 2009
The main product of the conversion of puerarin by unpermeabilized cells of bacterium Microbacterium oxydans CGMCC 1788 was puerarin-7-O-glucoside (241 +/- 31.9 microM). Permeabilization with 40% ethanol could not increase conversion yield, whereas it resulted in change of main product; a previous trace product became a main product (213 +/- 48.0 microM)
Cigang, Yu +9 more
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The main product of the conversion of puerarin by unpermeabilized cells of bacterium Microbacterium oxydans CGMCC 1788 was puerarin-7-O-glucoside (241 +/- 31.9 microM). Permeabilization with 40% ethanol could not increase conversion yield, whereas it resulted in change of main product; a previous trace product became a main product (213 +/- 48.0 microM)
Cigang, Yu +9 more
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Puerarin: A Review of Pharmacological Effects
Phytotherapy Research, 2013Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated.
Yan-Xi, Zhou, Hong, Zhang, Cheng, Peng
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Effects of glycyrrhizin on the pharmacokinetics of puerarin in rats
Xenobiotica, 20171. Puerarin has been reported to possess a wide range of pharmacological activities. This study investigated the effects of glycyrrhizin on the pharmacokinetics of puerarin in rats. 2. The pharmacokinetics of orally administered puerarin (50 mg/kg) with or without glycyrrhizin pretreatment (100 mg/kg/day for 7 days) were investigated.
Qun, Zhao +3 more
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