Results 61 to 70 of about 6,488 (202)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Bone induction using puerarin

, 2007
AIM: Puerarin is one of the major phytoestrogens isolated from Pueraria lobata, a Chinese medicine known as Gegen. The aim of this investigation was to compare the amount of new bone produced by puerarin in collagen matrix (carrier) to that produced by
Wong, RWK, Rabie, ABM
core   +1 more source

Puerarin inhibits hepatocellular carcinoma invasion and metastasis through miR-21-mediated PTEN/AKT signaling to suppress the epithelial-mesenchymal transition

Brazilian Journal of Medical and Biological Research
Hepatocellular carcinoma (HCC) is one of the most common primary malignant tumors of the liver worldwide. Liver resection and transplantation are currently the only effective treatments; however, recurrence and metastasis rates are still high.
Yuan Zhou, Ruifeng Xue, Jinglin Wang, Haozhen Ren   +3 more
doaj   +1 more source

Puerarin enhances intestinal function in piglets infected with porcine epidemic diarrhea virus

Scientific Reports, 2021
Puerarin has been reported to be an excellent antioxidant, anti-inflammatory and antimicrobial agent, but the potential effect of puerarin on porcine epidemic diarrhea virus (PEDV) is unclear.
Mengjun Wu, Dan Yi, Qian Zhang, Tao Wu, Kui Yu, Meng Peng, Lei Wang, Di Zhao, Yongqing Hou, Guoyao Wu   +9 more
doaj   +1 more source

Classification, Structure–Activity Relationship, and Anti‐Osteoarthritis Mechanism of Natural Flavonoids

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Natural product flavonoids have a multi‐target therapeutic intervention effect on osteoarthritis. They promote autophagy and cartilage synthesis while alleviating oxidative stress, inhibiting inflammation, and inhibiting matrix degradation. By restoring OPG/RANKL balance and regulating bone metabolism, these compounds synergistically delay the ...
Haibin Wang, Shuqi Zheng, Chunlei Hua, Wanze Feng, Zengxia Liu, Yanhong Sun, Minhui Li   +6 more
wiley   +1 more source

Urinary and Biliary Metabolites of Puerarin in Rats.

Biological and Pharmaceutical Bulletin, 1995
Examination was made of the urinary and biliary excretion of the metabolites of puerarin, the major component of the roots of Pueraria lobata OHWI (Leguminosae) in rats. The urine of rats administered puerarin orally contained puerarin and four major metabolites, daidzein 4',7-di-O-sulfate (M-I), daidzein 7-O-beta-D-glucuronide (M-II), daidzein 4'-O ...
YASUDA, Takaaki, KANO, Yoshihiro, SAITO, Kenichi, OHSAWA, Keisuke   +3 more
openaire   +3 more sources

Kiwifruit Seed Polyphenols Ameliorate High‐Fat‐Induced Obese Mice via Inhibition of Inflammation and Regulation of Gut Microbiota Balance

Food Frontiers, Volume 7, Issue 5, September 2026.
Kiwifruit seed polyphenols (KSP) alleviate high‐fat diet‐induced obesity and metabolic dysfunction in mice by reducing body weight gain, adiposity, hepatic steatosis, and insulin resistance. KSP also suppresses inflammation, improves lipid metabolism, and reshapes gut microbiota composition, restoring short‐chain fatty acid production, thereby ...
Qingqing Liu, Jianxin Huang, Jinyue Xu, Qi Zhang, Ying Zhang, Haixia Yang, Wei Cao, Jianjun Deng   +7 more
wiley   +1 more source

Puerarin modulates proliferation, inflammation and ECM metabolism in human nucleus pulposus mesenchymal stem cells via the lncRNA LINC01535

Heliyon
Background: Intervertebral disc degeneration (IVDD) is a highly prevalent musculoskeletal disorder characterized by progressive destruction of the intervertebral disc, leading to chronic low back pain and disability.
Penglei Cui, Yueyang Sheng, Chengai Wu, Da He   +3 more
doaj   +1 more source

Development of an Oral Compound Pickering Emulsion Composed of Nanocrystals of Poorly Soluble Ingredient and Volatile Oils from Traditional Chinese Medicine

Pharmaceutics, 2018
In this study, an oral drug nanocrystals self-stabilized Pickering emulsion (NSSPE), which used nanocrystals of a poorly soluble ingredient from Puerariae Radix called puerarin as solid particle stabilizers and Ligusticum chuanxiong essential oil since ...
Jifen Zhang, Jiao Zhang, Shuai Wang, Tao Yi   +3 more
doaj   +1 more source

Puerarin‐Loaded Macrophage‐Derived Exosomes for Experimental Atherosclerosis

Food Frontiers, Volume 7, Issue 5, September 2026.
We developed a macrophage‐derived exosome‐based delivery system to enhance the therapeutic efficacy of puerarin (Pue) against atherosclerosis (AS). Exosomes were isolated from RAW264.7 cells, co‐cultured with Pue, and comprehensively characterized for morphology, stability, and drug loading.
Zijian Zou, Liangxing Tu, Ye Yang, Jianfang Feng, Yi Jin, Ruyue Yang, Meng Cheng   +6 more
wiley   +1 more source