Results 81 to 90 of about 6,488 (202)

Puerarin-loaded PEG-PE micelles with enhanced anti-apoptotic effect and better pharmacokinetic profile

, 2018
Puerarin (PUE) is the most abundant isoflavonoid in kudzu root. It is widely used as a therapeutic agent for the treatment of cardiovascular diseases. However, the short elimination half-life, poor-bioavailability, and acute intravascular hemolysis of ...
Shilin Luo, Jiang Zhang (453299), Jingjing Wang (140791), Xinyi Liu, Shilin Luo (3824935), Daxiong Xiang, Daxiong Xiang (5023772), Jingjing Wang, Jianhe Li, Jiang Zhang, Xinyi Liu (186154), Wenqun Li, Junyong Wu (2029666), Junyong Wu, Wenqun Li (5023769), Jianhe Li (387066)   +15 more
core   +1 more source

Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats

Acta Biochimica et Biophysica Sinica
Previous studies have shown that puerarin plays a key role in protecting humans and animals from cardiovascular diseases. The exact mechanism of the therapeutic effect of puerarin on various cardiovascular diseases (protective effect on cardiomyocytes ...
Pan Guopin, Cui Baoyue, Han Mingming, Lin Laibiao, Li Yinlan, Wang Ling, Guo Shuang, Yin Yaling, Zhan Heqin, Li Peng   +9 more
doaj   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Puerarin Acts Through Brain Serotonergic Mechanisms to Induce Thermal Effects.

, 2012
[[abstract]]The present study was attempted to investigate the effect of puerarin, an isoflavone compound isolated from Pueraria lobata, on both the basal body temperature and pyrogenic fever in unanesthetized, restrained rats.
Fu-Shin Chueh;Ching-Ping Chang;Chung-Ching Chio;Mao-Tsun Lin
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Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies

Drug Delivery, 2017
Now there are few good oral preparations of puerarin used in cerebrovascular diseases because of its poor oral absorption caused by the low water solubility and the poor penetration into brain.
Tao Yi, Dandan Tang, Fan Wang, Jiqiong Zhang, Jiao Zhang, Jirui Wang, Xiaoyu Xu, Jifen Zhang   +7 more
doaj   +1 more source

Strategies for Target Identification and Mechanism Elucidation in Phytochemicals

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Strategies for Target Identification of Phytochemicals: Labeling Methods VS. Non‐Labeling Methods ABSTRACT Drug targets serve as the fundamental biological basis through which phytochemicals exert their therapeutic effects, and target discovery represents both the core challenge and the rate‐limiting step in elucidating the mechanisms of action of ...
Jialing Chen, Yan Linghu, Dasong Wang, Weidong Pan, Kegang Linghu   +4 more
wiley   +1 more source

Research Progress on Alleviating Inflammatory Responses by Regulating Macrophage Polarization Using Medicinal and Edible Homologous Traditional Chinese Medicines

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
This review summarizes that medicinal and edible homologous TCMs—such as Mongolian milkvetch root, common turmeric rhizome, and Angelica—alleviate chronic inflammatory diseases (IBD, RA, and AS) by inhibiting M1 and promoting M2 macrophage polarization, providing a theoretical basis for inflammation therapy and daily dietary intervention.
Cheng Zhang, Xinyi Liu, Wenlin Chen, Weilin Song, Junjie Cai, Cheng Liang, Jun Shen, Ruoxuan Liu, Yiming Xu, Chunhui Li, Chenghong Li, Yuyuan Wu, Xinyi Li, Chuwen Li, Hongxun Tao, Yuanye Dang   +15 more
wiley   +1 more source

Puerarin exhibits greater distribution and longer retention time in neurons than astrocytes in a co-cultured system

Neural Regeneration Research, 2015
The phytoestrogen puerarin has been shown to protect neurons and astrocytes in the brain, and is therefore an attractive drug in the treatment of Alzheimer′s disease, Parkinson′s disease and cerebral ischemia.
Shu-Yong Wei, Jie Tong, Qiang Xue, Fang-hong Shang, Yan-jun Li, Yang Liu, Bin-bin Feng, Xiao-yu Xu   +7 more
doaj   +1 more source

Furong Tongmai Capsule Ameliorates Atherosclerosis in ApoE−/− Mice by Modulating Gut Microbiota, Arachidonic Acid Metabolism and Macrophage Polarization

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Furong Tongmai capsule (FRTM) is a traditional Chinese medicine formula with reported lipid‐lowering and anti‐inflammatory activities, but its mechanisms in atherosclerosis (AS) remain unclear. In ApoE−/− mice fed a high‐fat diet, FRTM administration improved serum lipid profiles by reducing total cholesterol, triglycerides and low‐density ...
Shuquan Lv, Hanzhou Li, Yuming Wang, Xiuxiu Sang, Feng Wang, Jing Yang, Lirong Fan, Ziang Ma, Lixin Wang, Yuhong Bian, Huantian Cui   +10 more
wiley   +1 more source

Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin and menthol

, 2017
Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Hui-Chao Wu, Zhi-Hao Tian, Min Wang, Chang Yang School of Chinese Materia Medica, Beijing University of Chinese Medicine, Chaoyang District, Beijing, People’s Republic of China Abstract: Nose-to-brain ...
Tian Z, Wang M, Du S, Lu Y, Zhang L, Liu C, Yang C, Wu H   +7 more
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