Results 71 to 80 of about 114,514 (356)

miR-24 is involved in vertebrate LC-PUFA biosynthesis as demonstrated in marine teleost Siganus canaliculatus [PDF]

, 2019
Recently, microRNAs (miRNAs) have emerged as crucial regulators of lipid metabolism. However, the miRNA-mediated regulatory mechanism on long-chain (≥C20) polyunsaturated fatty acids (LC-PUFA) biosynthesis in vertebrates remains largely unknown. Here, we
You, Cuihong, Tocher, Douglas R, Tocher, Douglas R., Chen, Baojia, Xie, Dizhi, Liu, Yang, Wang, Shuqi, Zhang, Mei, Monroig, Óscar, Li, Yuanyou, Waiho, Khor, Chen, Cuiying   +11 more
core   +1 more source

Identification of miR-145 as a Key Regulator Involved in LC-PUFA Biosynthesis by Targeting hnf4α in the Marine Teleost Siganus canaliculatus [PDF]

, 2020
Fish, particularly marine species, are considered as the major source of long-chain polyunsaturated fatty acids (LC-PUFA) in the human diet. The extent to which fish can synthesize LC-PUFA varies with species and is regulated by dietary fatty acids and ...
You, Cuihong, Tocher, Douglas R, Wen, Xiaobo, Shen, Jiajian, Xie, Dizhi, Zhang, Mei, Li, Yuanyou, Wang, Shuqi, Monroig, Óscar, Chen, Cuiying, He, Xianda, Hu, Yu   +11 more
core   +1 more source

A Non‐Canonical Core Transcriptional Regulatory Circuit Orchestrates Chromatin Reprogramming to Drive Osimertinib Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu, Zhenguo Liu, Lizhen Jiang, Andong Huang, Xinqing Lin, Xinyue Li, Bingyuan Liu, Shiwen Hu, Qiang Pan, Junjun Huang, Liyuan Yin, Liling Jiang, Wei Yi, Wenjun Mao, Yueyuan Zheng, Xianping Shi   +15 more
wiley   +1 more source

Omega-3 PUFA Loaded in Resveratrol-Based Solid Lipid Nanoparticles: Physicochemical Properties and Antineoplastic Activities in Human Colorectal Cancer Cells In Vitro

International Journal of Molecular Sciences, 2018
New strategies are being investigated to ameliorate the efficacy and reduce the toxicity of the drugs currently used in colorectal cancer (CRC), one of the most common malignancies in the Western world.
S. Serini, R. Cassano, P. Corsetto, A. Rizzo, G. Calviello, S. Trombino   +5 more
semanticscholar   +1 more source

Characteristics of LC-PUFA biosynthesis in marine herbivorous teleost Siganus canaliculatus under different ambient salinities

, 2015
The present study aimed to characterize the influence of salinity on the biosynthesis of long-chain polyunsaturated fatty acid (LC-PUFA) in rabbitfishSiganus canaliculatus.
You, Cuihong, Tocher, Douglas R, Chen, Fang, Xie, Dizhi, Wang, Shuqi, Li, Yuanyou   +5 more
core   +1 more source

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Murine hepatic proteome adaptation to high-fat diets with different contents of saturated fatty acids and linoleic acid : α-linolenic acid polyunsaturated fatty acid ratios

Journal of Veterinary Research
Some health disorders, such as obesity and type 2 diabetes, are associated with a poor diet and low quality of the fat in it. The type and duration of the diet have an impact on the liver.
Liput Kamila P., Lepczyński Adam, Poławska Ewa, Ogłuszka Magdalena, Starzyński Rafał, Urbański Paweł, Nawrocka Agata, Jończy Aneta, Pierzchała Dorota, Pareek Chandra S., Gołyński Marcin, Woźniakowski Grzegorz, Czarnik Urszula, Pierzchała Mariusz   +13 more
doaj   +1 more source

Enrichment of Polyunsaturated fatty acids from catfish oil with immobilized Rhizopus oryzea lipase

Ho Chi Minh City Open University Journal of Science - Engineering and Technology, 2018
Nowadays, Pangasius hypophthalmus fillet is one of the main marine products in Vietnamese Mekong River Delta with over three hundred thousand tons per year. One of the byproducts of this industry is fat, about one hundred thousand tons per year.
Ly Thi Minh Hien
doaj   +1 more source

Revisiting the Role of LXRs in PUFA Metabolism and Phospholipid Homeostasis

International Journal of Molecular Sciences, 2019
Liver X receptors (LXRs) play a pivotal role in fatty acid (FA) metabolism. So far, the lipogenic consequences of in vivo LXR activation, as characterized by a major hepatic steatosis, has constituted a limitation to the clinical development of ...
A. Jalil, Thibaut Bourgeois, L. Ménégaut, L. Lagrost, C. Thomas, D. Masson   +5 more
semanticscholar   +1 more source

Genome wide identification and functional characterization of two LC-PUFA biosynthesis elongase (elovl8) genes in rabbitfish (Siganus canaliculatus) [PDF]

, 2020
Elongases of very long-chain fatty acids (Elovls) catalyze the rate-limiting step of the elongation pathway that results in net 2‑carbon elongation of pre-existing fatty acyl chains.
Wen, Zhengyong, You, Cuihong, Tocher, Douglas R, Li, Yang, Xie, Zhiyong, Wang, Shuqi, Li, Yuanyou, Zhang, Yueling   +7 more
core   +1 more source