Results 51 to 60 of about 80,002 (308)

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

open access: yesAdvanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao   +13 more
wiley   +1 more source

Influence of dietary linseed and sunflower oil on sensory characteristics of rainbow trout (Oncorhynchus mykiss)

open access: yesCzech Journal of Animal Science, 2006
This study describes the effects of dietary linseed and sunflower oil on the sensory characteristics of rainbow trout (Oncorhynchus mykiss) fillets. Rainbow trout were fed a diet containing either 2.5% or 5% of linseed or sunflower oil or 5% mixture of ...
Z. Drobná   +3 more
doaj   +1 more source

Characteristics of LC-PUFA biosynthesis in marine herbivorous teleost Siganus canaliculatus under different ambient salinities

open access: yes, 2015
The present study aimed to characterize the influence of salinity on the biosynthesis of long-chain polyunsaturated fatty acid (LC-PUFA) in rabbitfishSiganus canaliculatus.
You, Cuihong   +5 more
core   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu   +10 more
wiley   +1 more source

Influence of n-3 and n-6 polyunsaturated fatty acids on sensory characteristics of chicken meat

open access: yesCzech Journal of Animal Science, 2008
The relationship between different levels of n-6 and n-3 PUFA in chicken breast and thigh meat and sensory characteristics of meat was studied. Chickens were fed diets containing 1, 3, 5 or 7 percent of oil made of seeds either of the linseed cultivar ...
J. Zelenka   +2 more
doaj   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia   +8 more
wiley   +1 more source

Oil in Inajá Pulp (Maximiliana maripa): Fatty Acid Profile and Anti-acetylcholinesterase Activity

open access: yesOrbital: The Electronic Journal of Chemistry, 2016
The inajá (Maximiliana maripa) is a palm from Arecaceae family. The inajá distribution occurs from Amazon to the west-central of South America. The inajá has edible parts: the palm heart and oils obtained from pulp and seed.
Ismael Montero Fernandez   +9 more
doaj   +1 more source

Assessment of the Consequences of Dental Caries on the Body Mass Index in Children using the Pufa Index [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2018
Introduction: Dental caries continues to exert a significant influence on children’s overall health and the effect of untreated dental caries impacts dental health more than the presence of caries itself. Aim: To investigate the effect of consequences of
Nikita Vinod Dandekar   +2 more
doaj   +1 more source

Are total omega-3 and omega-6 polyunsaturated fatty acids predictors of fatal stroke in the Adventist Health Study 2 prospective cohort?

open access: yesPLoS ONE, 2022
IntroductionThe effects of omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) on cerebrovascular disease remain unsettled. However, most studies have focused on marine sourced n-3 PUFA rather than total n-3 PUFA, of which the majority in ...
Alan Cupino   +6 more
doaj   +1 more source

Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. [PDF]

open access: yes, 2013
BACKGROUND: Intestinal damage and malabsorption caused by chronic environmental enteropathy are associated with growth faltering seen in infants in less-developed countries.
Drammeh, Saikou   +13 more
core   +1 more source

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