Results 91 to 100 of about 591,821 (395)

Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma

Arthritis Care &Research, EarlyView.
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source

Micro-CT Image-Derived Metrics Quantify Arterial Wall Distensibility Reduction in a Rat Model of Pulmonary Hypertension [PDF]

, 2000
We developed methods to quantify arterial structural and mechanical properties in excised rat lungs and applied them to investigate the distensibility decrease accompanying chronic hypoxia-induced pulmonary hypertension. Lungs of control and hypertensive
Dawson, Christopher A, Haworth, Steven Thomas, Johnson, Roger H., Karau, Kelly L., Molthen, Robert C.   +4 more
core   +1 more source

Demographics and Outcomes of Pulmonary Hypertension Patients in United States Emergency Departments [PDF]

, 2020
Introduction: Pulmonary hypertension (PH) is a common, yet under-diagnosed, contributor to morbidity and mortality. Our objective was to characterize the prevalence of PH among adult patients presenting to United States (US) emergency departments (ED ...
Camargo Jr., Carlos A., Faridi, M. Kamal, Wilcox, Susan R.   +2 more
core  

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Pulmonary arterial hypertension: an update [PDF]

Netherlands Heart Journal, 2011
Pulmonary arterial hypertension (PAH), defined as group 1 of the World Heart Organisation (WHO) classification of pulmonary hypertension, is an uncommon disorder of the pulmonary vascular system. It is characterised by an increased pulmonary artery pressure, increased pulmonary vascular resistance and specific histological changes.
openaire   +3 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Left ventricular torsion rate and the relation to right ventricular function in pediatric pulmonary arterial hypertension

Pulmonary Circulation, 2018
The right ventricle and left ventricle are physically coupled through the interventricular septum. Therefore, changes in the geometry and mechanics of one ventricle can directly affect the function of the other.
Melanie J. Dufva, Uyen Truong, Pawan Tiwari, Dunbar D. Ivy, Robin Shandas, Vitaly O. Kheyfets   +5 more
doaj   +1 more source

Oxidative stress in patients with pulmonary hypertension

Advances in Redox Research, 2022
Rationale: Pulmonary arterial hypertension is a devastating cardiovascular disease that is progressive and fatal despite advances in therapy. Animal models have shown that oxidative stress may be pathogenic in pulmonary hypertension.
Tammy O. Wichman, Galo Martin Sanchez Palacios, Ross Davidson, Christopher S. Wichman, Matthew C. Zimmerman   +4 more
doaj   +1 more source

What every ICU clinician needs to know about the cardiovascular effects caused by abdominal hypertension [PDF]

, 2015
The effects of increased intra-abdominal pressure (IAP) on cardiovascular function are well recognized and include a combined negative effect on preload, afterload and contractility.
De Keulenaer, Bart L, De Waele, Jan, Malbrain, Manu LNG   +2 more
core   +1 more source

Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Right ventricular (RV) fibrosis in pulmonary arterial hypertension contributes to RV failure.
Lian Tian, Danchen Wu, A. Dasgupta, Kuang‐Hueih Chen, J. Mewburn, F. Potus, P. Lima, Z. Hong, Yuan-Yuan Zhao, Charles T. Hindmarch, S. Kutty, S. Provencher, S. Bonnet, G. Sutendra, S. Archer   +14 more
semanticscholar   +1 more source