Results 91 to 100 of about 560,791 (351)
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 [PDF]
, 2018 Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined.
Chen, Jiwang +6 more
core +1 more source
Pulmonary Artery Denervation for Pulmonary Artery Hypertension
JACC: Cardiovascular Interventions, 2015 While the seminal advance in the treatment of pulmonary artery hypertension (PAH) over the past 2 decades has been pharmacological targeting of dysfunctional endothelium-derived pathways that contribute to the characteristic vascular remodeling of this condition irrespective of etiology [(1)][1],
openaire +3 more sources
Advanced Science, EarlyView.The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang +28 more
wiley +1 more source
Haemodynamic definitions and updated clinical classification of pulmonary hypertension
European Respiratory Journal, 2019 Since the 1st World Symposium on Pulmonary Hypertension (WSPH) in 1973, pulmonary hypertension (PH) has been arbitrarily defined as mean pulmonary arterial pressure (mPAP) ≥25 mmHg at rest, measured by right heart catheterisation. Recent data from normal
G. Simonneau +7 more
semanticscholar +1 more source
The trajectory to diagnosis with pulmonary arterial hypertension: a qualitative study [PDF]
, 2012 Objectives To investigate the patient's experience of the trajectory to receiving a diagnosis of pulmonary arterial hypertension (PAH) and inform the provision of care for this patient group.
Armstrong, I +4 more
core +2 more sources
Association Between Cholecystectomy and Gastric Cancer in a Cohort Study in Taiwan
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Objective The association between cholecystectomy and gastric cancer is undetermined. The objective of this study was to assess whether subjects with cholecystectomy are at risk of gastric cancer in Taiwan. Methods This study used data from a cohort of 2 000 000 beneficiaries over a twelve‐year period (2010–2021) from the Taiwan National ...
Kuan‐Fu Liao +4 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.Deep learning‐based prediction model for operative mortality using the National Clinical Database (NCD). The model achieved a C‐statistic of 0.74. ABSTRACT Background Radical gastrectomy with lymph node dissection is the primary treatment for gastric cancer.
Ryosuke Fukuyo +5 more
wiley +1 more source
Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Although living‐donor liver transplantation (LDLT) has become the standard treatment for end‐stage liver disease, one of its major challenges is small‐for‐size syndrome (SFSS). SFSS is characterized by severe icterus and intractable ascites, although the severity of the condition can vary.
Toru Ikegami +6 more
wiley +1 more source
Clinical trial design and new therapies for pulmonary arterial hypertension
European Respiratory Journal, 2019 Until 20 years ago the treatment of pulmonary arterial hypertension (PAH) was based on case reports and small series, and was largely ineffectual. As a deeper understanding of the pathogenesis and pathophysiology of PAH evolved over the subsequent two ...
O. Sitbon +9 more
semanticscholar +1 more source
Pulmonary Circulation, 2020 The pathogenesis of pulmonary arterial hypertension is closely associated with dysregulated inflammation. Recently, abnormal alterations in gut microbiome composition and function were reported in a pulmonary arterial hypertension experimental animal ...
T. Sanada +14 more
semanticscholar +1 more source