Results 91 to 100 of about 445,623 (380)

Pulmonary arterial hypertension patients display normal kinetics of clot formation using thrombelastography

Pulmonary Circulation, 2021
Pulmonary arterial hypertension is characterized by endothelial dysfunction and microthrombi formation. The role of anticoagulation remains controversial, with studies demonstrating inconsistent effects on pulmonary arterial hypertension mortality ...
Mengyun Lu, Kevin P. Blaine, Ann Cullinane, Courtney Hall, Alina Dulau‐Florea, Junfeng Sun, Herman F. Chenwi, Grace M. Graninger, Bonnie Harper, Keshia Thompson, Janell Krack, Christopher F. Barnett, Samuel B. Brusca, Jason M. Elinoff, Michael A. Solomon   +14 more
doaj   +1 more source

Blockade of JAK2 protects mice against hypoxia‐induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation

Cell Proliferation, 2020
Hypoxia is an important risk factor for pulmonary arterial remodelling in pulmonary arterial hypertension (PAH), and the Janus kinase 2 (JAK2) is believed to be involved in this process.
Lei Zhang, Yi Wang, Guorao Wu, Lizong Rao, Yanqiu Wei, H. Yue, Ting Yuan, Ping Yang, Fei Xiong, Shu Zhang, Qing Zhou, Zhishui Chen, Jinxiu Li, B. Mo, Huilan Zhang, W. Xiong, Cong-Yi Wang   +16 more
semanticscholar   +1 more source

Echocardiography and Pulmonary Arterial Hypertension

Monaldi Archives for Chest Disease, 2016
Pulmonary Arterial Hypertension (PAH) is an heterogeneous condition brought on by a wide range of causes. It is characterized by structural changes in small pulmonary arteries, that produce a progressive increase in pulmonary artery pressure and pulmonary vascular resistance, ultimately leading to right ventricle failure and death.
Bossone Eduardo, Citro R, Ruggiero Alberto, Kuersten Bettina, Gregorio Giovanni, Blasi Francesco, Allegra Luigi   +6 more
openaire   +6 more sources

Inhibition and Rescue of Hyperglycemia‐Induced Cellular Senescence by Mitochondrial Transfer from Enucleated Mesenchymal Stem Cell‐Derived Microvesicles for Chronic Wound Healing

Advanced Science, EarlyView.
This study develops enucleated MSC‐derived microvesicles (Mito@euMVs) to deliver functional mitochondria for optimizing wound repair. By efficiently encapsulating mitochondria, Mito@euMVs rejuvenate hyperglycemia‐induced senescent fibroblasts and HUVECs. Using PVA microneedle patches, the therapeutic efficacy of Mito@euMVs is validated in diabetic rats
Zixuan Dong, Xiaobing Liu, Shichun Li, Xiaoling Fu   +3 more
wiley   +1 more source

Baicalin prevents pulmonary arterial remodeling in vivo via the AKT/ERK/NF-κB signaling pathways

Pulmonary Circulation, 2019
Pulmonary arterial hypertension is a rapidly progressive and often fatal disease. As the pathogenesis of pulmonary arterial hypertension remains unclear, there is currently no good drug for pulmonary arterial hypertension and new therapy is desperately ...
Guosen Yan, Jinxia Wang, Tao Yi, Junfen Cheng, Haixu Guo, Yuan He, Xiaorong Shui, Zeyong Wu, Shian Huang, Wei Lei   +9 more
doaj   +1 more source

Functions of ceramide and its role in pulmonary arterial hypertension [PDF]

Jichu yixue yu linchuang, 2021
Ceramide is a kind of sphingomyelin molecule,as a second messenger in cells,regulates cell proliferation,differentiation,senescence,apoptosis and other life activities.Pulmonary arterial hypertension is a disease characterized by pulmonary arterioles ...
LI Fa-mei, YU Zai-xin
doaj  

Riociguat for the treatment of pulmonary arterial hypertension.

New England Journal of Medicine, 2013
BACKGROUND Riociguat, a soluble guanylate cyclase stimulator, has been shown in a phase 2 trial to be beneficial in the treatment of pulmonary arterial hypertension.
H. Ghofrani, N. Galiè, F. Grimminger, E. Grünig, M. Humbert, Z. Jing, A. Keogh, D. Langleben, M. O. Kilama, A. Fritsch, D. Neuser, L. Rubin   +11 more
semanticscholar   +1 more source

Pulmonary hypertension and pulmonary artery dissection [PDF]

Jornal Brasileiro de Pneumologia, 2013
Pulmonary artery dissection is a fatal complication of long-standing pulmonary hypertension, manifesting as acute, stabbing chest pain, progressive dyspnea, cardiogenic shock, or sudden death. Its incidence has been underestimated, and therapeutic options are still scarce.
Corrêa, Ricardo de Amorim, Silva, Luciana Cristina dos Santos, Rezende, Cláudia Juliana, Bernardes, Rodrigo Castro, Prata, Tarciane Aline, Silva, Henrique Lima   +5 more
openaire   +6 more sources

A Dual‐Modal Wearable Pulse Detection System Integrated with Deep Learning for High‐Accuracy and Low‐Power Sleep Apnea Monitoring

Advanced Science, EarlyView.
A dual‐modal wearable pulse detection system is developed for sleep apnea monitoring by integrating a self‐powered PENG and PPG sensor with a biomimetic fingertip structure. Through a two‐stage detection strategy, continuous PPW monitoring and on‐demand PPG detection achieve high‐accuracy sleep apnea recognition while maintaining low power consumption.
Jia Wang, Jiangtao Xue, Yang Zou, Yuxin Ma, Junhan Xu, Yanming Li, Fei Deng, Yiqian Wang, Kai Xing, Zhou Li, Tong Zou   +10 more
wiley   +1 more source

“Anagrelide-induced pulmonary arterial hypertension”: a rare case of drug-induced pulmonary arterial hypertension

Pulmonary Circulation, 2019
Pulmonary arterial hypertension can be associated with exposure to certain drugs or toxins. However, only a few cases of drug-induced pulmonary arterial hypertension have been previously reported.
Keiko Sumimoto, Yu Taniguchi, Yoichiro Matsuoka, Hiroyuki Onishi, Noriaki Emoto, Ken-ichi Hirata   +5 more
doaj   +1 more source