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Pulmonary arterial hypertension [PDF]
Orphanet Journal of Rare Diseases, 2013 Pulmonary arterial hypertension (PAH) is a chronic and progressive disease leading to right heart failure and ultimately death if untreated. The first classification of PH was proposed in 1973. In 2008, the fourth World Symposium on PH held in Dana Point
D. Montani +12 more
semanticscholar +9 more sources
Cardiac sympathetic dysfunction in pulmonary arterial hypertension: lesson from left-sided heart failure [PDF]
Pulmonary Circulation, 2019 Sympathetic nervous system hyperactivity has a well-recognized role in the pathophysiology of heart failure with reduced left ventricular ejection fraction.
Valentina Mercurio +10 more
doaj +2 more sources
PULMONARY ARTERIAL HYPERTENSION [PDF]
Annals of Medicine, 2006 Pulmonary arterial hypertension is a disease of the small pulmonary arteries characterized by vascular narrowing and increased pulmonary vascular resistance, which eventually leads to right ventricular failure. Vasoconstriction, vascular proliferation, remodeling of the pulmonary vessels, and thrombosis are all contributing factors to the increased ...
Joseph Loscalzo, Azad Raiesdana
+13 more sources
Pulmonary arterial hypertension [PDF]
Medicina, 2007 Pulmonary arterial hypertension is a life-threatening, progressive disorder of pulmonary blood vessels leading to an increase in pressure in pulmonary artery. Diagnosis is based on a mean pulmonary artery pressure of more than 25 mmHg at rest or more than 30 mmHg during exercise. No cure exists for it yet.
Harry L. Messmore +3 more
+9 more sources
Pulmonary arterial hypertension [PDF]
Internal and Emergency Medicine, 2009 In Internal and Emergency Medicine, Wu and coworkers [1] review the topic of pulmonary arterial hypertension. Overall, their article is sound and pertinent; however, some issues deserve comments. First, the value of chest radiography in the diagnostic process is somewhat overlooked.
Aydin Uzunpinar, Mehmet Cilingiroglu
+11 more sources
Transient but not genetic loss of miR-451 attenuates the development of pulmonary arterial hypertension [PDF]
, 2013 <b>Rationale:</b> MicroRNAs are small non-coding RNAs involved in the regulation of gene expression and have recently been implicated in the development of pulmonary arterial hypertension (PAH).
Baker, Andrew H. +5 more
core +13 more sources
Pulmonary arterial hypertension [PDF]
Breathe, 2005 Key pointsPAH is defined by RHC showing a pre-capillary PH.Clinical suspicion of PH should arise in the case of symptoms such as dyspnoea without overt signs of specific heart or lung disease.RHC is required to confirm the diagnosis of PAH, to assess the severity of the haemodynamic impairment and to test the vasoreactivity of the pulmonary circulation.
Xavier Jaïs +5 more
openaire +4 more sources
Pulmonary Arterial Hypertension
Journal of the American College of Cardiology, 2008 Significant advances in the treatment of pulmonary arterial hypertension (PAH) have occurred over the last 10 years, starting with the approval of epoprostenol in 1998. Subsequently, multiple additional medications have received approval, including a subcutaneous prostacyclin, an inhaled prostacyclin, and oral medications in 2 separate classes.
Kelly Chin, Lewis J. Rubin
openaire +6 more sources
Cell Proliferation, 2021 High‐mobility group box‐1 (HMGB1) and aberrant mitochondrial fission mediated by excessive activation of GTPase dynamin‐related protein 1 (Drp1) have been found to be elevated in patients with pulmonary arterial hypertension (PAH) and critically ...
Wei Feng +12 more
semanticscholar +1 more source
Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension
HYPERTENSION, 2020 Supplemental Digital Content is available in the text. Pulmonary arterial hypertension (PAH) is considered a disease of the pulmonary vasculature. Limited progress has been made in preventing or arresting progression of PAH despite extensive efforts. Our
Seungbum Kim +6 more
semanticscholar +1 more source