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Pulmonary arterial hypertension [PDF]

Orphanet Journal of Rare Diseases, 2013
Pulmonary arterial hypertension (PAH) is a chronic and progressive disease leading to right heart failure and ultimately death if untreated. The first classification of PH was proposed in 1973. In 2008, the fourth World Symposium on PH held in Dana Point
D. Montani, S. Günther, P. Dorfmüller, F. Perros, B. Girerd, G. Garcia, X. Jaïs, L. Savale, Élise Artaud-Macari, L. Price, M. Humbert, G. Simonneau, O. Sitbon   +12 more
semanticscholar   +4 more sources

PULMONARY ARTERIAL HYPERTENSION [PDF]

Annals of Medicine, 2006
Pulmonary arterial hypertension is a disease of the small pulmonary arteries characterized by vascular narrowing and increased pulmonary vascular resistance, which eventually leads to right ventricular failure. Vasoconstriction, vascular proliferation, remodeling of the pulmonary vessels, and thrombosis are all contributing factors to the increased ...
Azad, Raiesdana, Joseph, Loscalzo
  +9 more sources

Pulmonary arterial hypertension [PDF]

Current Atherosclerosis Reports, 2009
Pulmonary arterial hypertension is a progressive disease of pulmonary vasculature characterized by increased mean pulmonary arterial pressure and elevated vascular resistance with normal left-sided pressures, differentiating it from left-sided heart disease.
Aydin, Uzunpinar, Mehmet, Cilingiroglu
  +7 more sources

Pulmonary arterial hypertension

Medicina, 2007
Pulmonary arterial hypertension is a life-threatening, progressive disorder of pulmonary blood vessels leading to an increase in pressure in pulmonary artery. Diagnosis is based on a mean pulmonary artery pressure of more than 25 mmHg at rest or more than 30 mmHg during exercise. No cure exists for it yet.
José Luis, Puglisi, William H, Wehrmacher, Harry, Messmore, Donald M, Bers   +3 more
  +7 more sources

Pulmonary arterial hypertension [PDF]

Breathe, 2005
Key pointsPAH is defined by RHC showing a pre-capillary PH.Clinical suspicion of PH should arise in the case of symptoms such as dyspnoea without overt signs of specific heart or lung disease.RHC is required to confirm the diagnosis of PAH, to assess the severity of the haemodynamic impairment and to test the vasoreactivity of the pulmonary circulation.
D, Montani, X, Jaïs, O, Sitbon, F, Capron, G, Simonneau, M, Humbert   +5 more
openaire   +3 more sources

Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2022
Background Current mortality data for pulmonary arterial hypertension (PAH) in the United States are based on registries that enrolled patients prior to 2010.
Kevin Y. Chang, S. Duval, D. Badesch, T. Bull, M. Chakinala, T. De Marco, R. Frantz, A. Hemnes, S. Mathai, E. Rosenzweig, J. Ryan, T. Thenappan   +11 more
semanticscholar   +1 more source

COMPERA 2.0: a refined four-stratum risk assessment model for pulmonary arterial hypertension

European Respiratory Journal, 2021
Background Risk stratification plays an essential role in the management of patients with pulmonary arterial hypertension (PAH). The current European guidelines propose a three-stratum model to categorise risk as low, intermediate or high, based on the ...
M. Hoeper, C. Pausch, K. Olsson, D. Huscher, D. Pittrow, E. Grünig, G. Staehler, C. Vizza, H. Gall, O. Distler, C. Opitz, J. Gibbs, M. Delcroix, H. Ghofrani, D. Park, R. Ewert, H. Kaemmerer, H. Kabitz, D. Skowasch, J. Behr, K. Milger, M. Halank, H. Wilkens, H. Seyfarth, M. Held, D. Dumitrescu, I. Tsangaris, A. Vonk-Noordegraaf, S. Ulrich, H. Klose, M. Claussen, T. Lange, S. Rosenkranz   +32 more
semanticscholar   +1 more source

Pulmonary Arterial Hypertension [PDF]

New England Journal of Medicine, 2004
Pulmonary arterial hypertension (PAH) is characterized by vascular obstruction and the variable presence of vasoconstriction, leading to increased pulmonary vascular resistance and right-sided heart failure. PAH can present in an idiopathic form, usually called primary pulmonary hypertension (PPH), and PAH is also associated with the scleroderma ...
Harrison W, Farber, Joseph, Loscalzo
openaire   +3 more sources

Endothelial cells in the pathogenesis of pulmonary arterial hypertension

European Respiratory Journal, 2021
Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and development of plexiform lesions.
C. Evans, N. Cober, Z. Dai, D. Stewart, You-yang Zhao   +4 more
semanticscholar   +1 more source

The physiological basis of pulmonary arterial hypertension

European Respiratory Journal, 2021
Pulmonary arterial hypertension (PAH) is a rare dyspnoea-fatigue syndrome caused by a progressive increase in pulmonary vascular resistance and eventual right ventricular (RV) failure.
R. Naeije, M. Richter, L. Rubin
semanticscholar   +1 more source