Schistosomiasis Pulmonary Arterial Hypertension [PDF]
Frontiers in Immunology, 2020 Pulmonary arterial hypertension (PAH) is a disease of the lung blood vessels that results in right heart failure. PAH is thought to occur in about 5% to 10% of patients with hepatosplenic schistosomiasis, particularly due to S. mansoni. The lung blood vessel injury may result from a combination of embolization of eggs through portocaval shunts into the
Virginia Pacheco Guimaraes +24 more
openaire +6 more sources
Genetics of Pulmonary Arterial Hypertension [PDF]
Seminars in Respiratory and Critical Care Medicine, 2009 Tremendous progress has been made in understanding the genetics of pulmonary arterial hypertension (PAH) since its description in the 1950s as a primary disorder of the pulmonary vasculature. Heterozygous germline mutations in the gene coding bone morphogenetic receptor type 2 (BMPR2) are detectable in the majority of cases of heritable PAH, and in ...
Joshua D. Chew +2 more
openaire +4 more sources
Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension [PDF]
, 2014 Pulmonary arterial hypertension is a major complication of systemic sclerosis. Although oxidative stress, intima hyperplasia and a progressive vessel occlusion appear to be clearly involved, the fine molecular mechanisms underpinning the onset and ...
Boin, Francesco +8 more
core +2 more sources
Quantification of Pulmonary Arterial Wall Distensibility Using Parameters Extracted from Volumetric Micro-CT Images [PDF]
, 1999 Stiffening, or loss of distensibility, of arterial vessel walls is among the manifestations of a number of vascular diseases including pulmonary arterial hypertension.
Dawson, Christopher A +3 more
core +2 more sources
Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study [PDF]
, 2017 BackgroundIdiopathic and heritable pulmonary arterial hypertension form a rare but molecularly heterogeneous disease group. We aimed to measure and validate differences in plasma concentrations of proteins that are associated with survival in patients ...
Abdul-Salam +29 more
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Cardiac sympathetic dysfunction in pulmonary arterial hypertension: Lesson from left-sided heart failure [PDF]
, 2019 Sympathetic nervous system hyperactivity has a well-recognized role in the pathophysiology of heart failure with reduced left ventricular ejection fraction.
Bonaduce, Domenico +10 more
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Pulmonary Circulation, 2020 This systematic review of literature and online reports critically appraised incidence and prevalence estimates of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension to identify the most accurate estimates.
L. Leber, A. Beaudet, A. Muller
semanticscholar +1 more source
European Respiratory Journal, 2019 Paediatric pulmonary arterial hypertension (PAH) shares common features of adult disease, but is associated with several additional disorders and challenges that require unique approaches.
E. Rosenzweig +7 more
semanticscholar +1 more source
Echocardiographic assessment of pulmonary hypertension: a guideline protocol from the British Society of Echocardiography. [PDF]
, 2018 Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg as confirmed on right heart catheterisation. Traditionally, the pulmonary arterial systolic pressure has been estimated on echo by utilising the simplified Bernoulli equation from ...
Augustine, DX +20 more
core +3 more sources
Perivascular Inflammation in Pulmonary Arterial Hypertension
Cells, 2020 Perivascular inflammation is a prominent pathologic feature in most animal models of pulmonary hypertension (PH) as well as in pulmonary arterial hypertension (PAH) patients.
Yijie Hu +3 more
semanticscholar +1 more source