Results 81 to 90 of about 591,821 (395)

Metabolomics of exercise pulmonary hypertension are intermediate between controls and patients with pulmonary arterial hypertension

Pulmonary Circulation, 2019
Mechanisms underlying pulmonary arterial hypertension (PAH) remain elusive. Pulmonary arterial hypertension and exercise PH share similar physiologic consequences; it is debated whether they share biologic mechanisms and if exercise PH represents an ...
Jason L. Sanders, Yuchi Han, Mariana F. Urbina, David M. Systrom, Aaron B. Waxman   +4 more
doaj   +1 more source

Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training

Frontiers in Physiology, 2023
Pulmonary arterial hypertension is associated with skeletal muscle myopathy and atrophy and impaired exercise tolerance. Aerobic exercise training has been recommended as a non-pharmacological therapy for deleterious effects imposed by pulmonary arterial
Filipe Rios Drummond, Luciano Bernardes Leite, Denise Coutinho de Miranda, Denise Coutinho de Miranda, Lucas Rios Drummond, Victor Neiva Lavorato, Leôncio Lopes Soares, Clóvis Andrade Neves, Antônio José Natali   +8 more
doaj   +1 more source

Changes in Pulmonary Arterial Wall Mechanical Properties and Lumenal Architecture with Induced Vascular Remodeling [PDF]

, 2004
To explore and quantify pulmonary arterial remodeling we used various methods including micro-CT, high-resolution 3-dimensional x-ray imaging, to examine the structure and function of intact pulmonary vessels in isolated rat lungs.
Dawson, Christopher A, Haworth, Steven Thomas, Heinrich, Amy, Molthen, Robert C.   +3 more
core   +1 more source

Cellular senescence impairs the reversibility of pulmonary arterial hypertension

Science Translational Medicine, 2020
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis. Reversing maladaptive remodeling Pathologic vascular remodeling of pulmonary arterial hypertension (PAH ...
D. E. van der Feen, Guido P. L. Bossers, Q. Hagdorn, J. Moonen, K. Kurakula, R. Szulcek, James Chappell, Francesco Vallania, Michele Donato, K. Kok, J. Kohli, A. Petersen, T. van Leusden, M. Demaria, M. Goumans, R. D. de Boer, P. Khatri, M. Rabinovitch, R. Berger, B. Bartelds   +19 more
semanticscholar   +1 more source

Pulmonary Arterial Hypertension: Iron Matters [PDF]

Frontiers in Physiology, 2018
The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight regulation of these interactions including homeostatic regulation of iron utilization ensures safe usage of this limited resource. However, when control is lost adverse events can ensue, which are known to contribute to an array of disease processes.
Ramakrishnan, L, Pedersen, S, Toe, Q, Quinlan, GJ, Wort, S   +4 more
openaire   +5 more sources

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source

Pulmonary arterial hypertension patients display normal kinetics of clot formation using thrombelastography

Pulmonary Circulation, 2021
Pulmonary arterial hypertension is characterized by endothelial dysfunction and microthrombi formation. The role of anticoagulation remains controversial, with studies demonstrating inconsistent effects on pulmonary arterial hypertension mortality ...
Mengyun Lu, Kevin P. Blaine, Ann Cullinane, Courtney Hall, Alina Dulau‐Florea, Junfeng Sun, Herman F. Chenwi, Grace M. Graninger, Bonnie Harper, Keshia Thompson, Janell Krack, Christopher F. Barnett, Samuel B. Brusca, Jason M. Elinoff, Michael A. Solomon   +14 more
doaj   +1 more source

Genetics and genomics of pulmonary arterial hypertension

European Respiratory Journal, 2019
Since 2000 there have been major advances in our understanding of the genetic and genomics of pulmonary arterial hypertension (PAH), although there remains much to discover. Based on existing knowledge, around 25–30% of patients diagnosed with idiopathic
N. Morrell, M. Aldred, W. Chung, C. G. Elliott, William C Nichols, F. Soubrier, R. Trembath, James E. Loyd   +7 more
semanticscholar   +1 more source

Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension

Antioxidants and Redox Signaling, 2020
Endothelial-to-mesenchymal transition (EndMT) is a process that encompasses extensive transcriptional reprogramming of activated endothelial cells leading to a shift toward mesenchymal cellular phenotypes and functional responses.
A. Gorelova, M. Berman, I. Al Ghouleh
semanticscholar   +1 more source

Pulmonary Artery Hypertension

Journal of the Practice of Cardiovascular Sciences, 2021
Pulmonary artery hypertension (PAH) is a rare progressive disease affecting pulmonary arterial vasculature and the right side of the heart. The disease is notorious for its ominous course and high accelerated rates of mortality. Due to its varied etiology, it requires stepwise evaluation to differentiate various causes of PAH.
Mohit Bhagwati, Rahul Mehrotra
openaire   +2 more sources