Results 81 to 90 of about 560,791 (351)

SIRT6 Lysine‐Demyristoylates ATF2 to Ameliorate Vascular Injury via PRKCD/VE‐Cadherin Pathway Regulating Vascular Endothelial Barrier

Advanced Science, EarlyView.
A novel modified SIRT6 variant (dSIRT6) H133Y‐mediated enrichment technique unmasks 15 new human lysine‐myristoylated proteins. Notably, Sirtuin 6 (SIRT6) demyristoylation of activating transcription factor 2 (ATF2) at K296 orchestrates its nucleoplasmic translocation.
Runyang Feng, Zheyan Fang, Shuang Zhao, You‐en Zhang, Na Wu, Zhenyang Guo, Xin Zhong, Bixuan Jiang, Hongfei Xu, Hangnan Hong, Zhentao Zhang, Mukaddas Abdurahman, Xueting Yu, Jilong Geng, Xiansu Nie, Supuya Abuduwahapi, Dong Huang, Gang Zhao, Wenbin Zhang, Hao Lu, Li Shen, Xin Zhao, Zhaoyang Chen, Junjie Guo, Hongchao Zheng, Yue He, Sanwu Wu, Jiayin Peng, Jiawen Song, Xiao Wang, Haomin Li, Yuli Huang, Shengying Qin, Haojie Lu, Xiangdong Wang, Jianguo Zhao, Lei Huang, Yun Zhao, Peng Li, Junbo Ge, Hua Li   +40 more
wiley   +1 more source

Definition, classification and diagnosis of pulmonary hypertension

European Respiratory Journal
Pulmonary hypertension (PH) is a haemodynamic condition characterised by elevation of mean pulmonary arterial pressure (mPAP) >20 mmHg, assessed by right heart catheterisation.
Gabor Kovacs, Sonja Bartolome, C. Denton, M. A. Gatzoulis, Sue Gu, Dinesh Khanna, David B Badesch, D. Montani   +7 more
semanticscholar   +1 more source

Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome

Advanced Science, EarlyView.
Shear‐activated nanoparticles carrying nitroglycerin selectively target high‐shear stress collateral vessels during ischaemic stroke, enhancing blood flow to at‐risk brain without systemic side effects. This novel approach significantly improves outcomes in animal models, outperforming conventional nitroglycerin delivery.
Magdalena Litman, Sara Azarpeykan, Rebecca J Hood, Kristy Martin, Debbie Pepperall, Daniel Omileke, Fern Williams, Oktay Uzun, Deen Bhatta, Yuen K Yong, Alex Chan, Nicholas Hough, Sarah Johnson, Pablo Garcia Bermejo, Ferdinand Miteff, Carlos Garcia Esperon, Yvonne Couch, Alastair M Buchan, Neil J Spratt, Netanel Korin, Donald E Ingber, Daniel J Beard   +21 more
wiley   +1 more source

Care of patients with pulmonary arterial hypertension during the coronavirus (COVID-19) pandemic

Pulmonary Circulation, 2020
The COVID-19 pandemic presents many unique challenges when caring for patients with pulmonary hypertension. The COVID-19 pandemic has altered routine standard of care practice and the acute management particularly for those patients with pulmonary ...
J. Ryan, L. Melendres‐Groves, R. Zamanian, R. Oudiz, M. Chakinala, E. Rosenzweig, M. Gomberg-Maitland   +6 more
semanticscholar   +1 more source

Role of prostacyclin in pulmonary hypertension [PDF]

, 2014
Date of Acceptance: 11/12/2014 This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY-4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is ...
Ali FY, Butrous G, Chester AH, Geiger LE, Newsholme SJ, Nguyen H, Ruan CH, Smith WL, Whittaker N   +8 more
core   +3 more sources

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Pulmonary hypertension and pulmonary artery dissection [PDF]

Jornal Brasileiro de Pneumologia, 2013
Pulmonary artery dissection is a fatal complication of long-standing pulmonary hypertension, manifesting as acute, stabbing chest pain, progressive dyspnea, cardiogenic shock, or sudden death. Its incidence has been underestimated, and therapeutic options are still scarce.
Corrêa, Ricardo de Amorim, Silva, Luciana Cristina dos Santos, Rezende, Cláudia Juliana, Bernardes, Rodrigo Castro, Prata, Tarciane Aline, Silva, Henrique Lima   +5 more
openaire   +6 more sources

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Identification of rare sequence variation underlying heritable pulmonary arterial hypertension

Nature Communications, 2018
Pulmonary arterial hypertension (PAH) is a rare disorder with a poor prognosis. Deleterious variation within components of the transforming growth factor-β pathway, particularly the bone morphogenetic protein type 2 receptor (BMPR2), underlies most ...
S. Gräf, M. Haimel, M. Bleda, C. Hadinnapola, L. Southgate, L. Southgate, Wei Li, J. Hodgson, Bin Liu, R. Salmon, M. Southwood, R. Machado, Jennifer M. Martin, C. Treacy, C. Treacy, Katherine Yates, L. Daugherty, O. Shamardina, Deborah Whitehorn, Simon Holden, M. Aldred, H. Bogaard, Colin Church, G. Coghlan, R. Condliffe, P. Corris, C. Danesino, M. Eyries, Henning Gall, Stefano Ghio, H. Ghofrani, H. Ghofrani, J. S. R. Gibbs, B. Girerd, A. Houweling, Luke Howard, Marc Humbert, D. Kiely, Gabor Kovacs, R. Ross, S. Moledina, D. Montani, M. Newnham, Andrea Olschewski, H. Olschewski, A. Peacock, Joanna Pepke-Zaba, Inga Prokopenko, Christopher J. Rhodes, L. Scelsi, Werner Seeger, F. Soubrier, D. Stein, J. Suntharalingam, E. Swietlik, M. Toshner, D. A. Heel, A. Noordegraaf, Q. Waisfisz, J. Wharton, S. J. Wort, W. Ouwehand, Nicole Soranzo, Nicole Soranzo, A. Lawrie, P. Upton, Martin R. Wilkins, R. Trembath, N. Morrell   +68 more
semanticscholar   +1 more source