Results 121 to 130 of about 211,135 (314)

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Clinical outcomes of upfront combination therapy for portopulmonary hypertension

International Journal of Cardiology. Cardiovascular Risk and Prevention
Background: Limited data exists on upfront combination therapy for portopulmonary hypertension. We evaluated the clinical efficacy, long-term outcomes, and safety of upfront combination therapy in patients with portopulmonary hypertension.
Takatoyo Kiko, Ryotaro Asano, Hiroyuki Endo, Naruhiro Nishi, Hiroya Hayashi, Jin Ueda, Tatsuo Aoki, Akihiro Tsuji, Takeshi Ogo   +8 more
doaj   +1 more source

Plasma adrenomedullin peptides and precursor levels in pulmonary arterial hypertension disease severity and risk stratification [Elektronisk resurs]

, 2020
Adrenomedullin is a potent vasodilatory peptide, linked to pulmonary arterial hypertension pathology. Proximity extension assays were utilized to study plasma biomarkers related to vasoregulation, with focus on adrenomedullin peptides and precursor ...
Bouzina, Habib,, Lund University., Rådegran, Göran,   +2 more
core   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

Advanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li, Zhonglian Cao, Rongrui Zhou, Xu Cheng, Xiaozhi Hu, Shuwen Xu, Zihan Dou, Ling Du, Dianwen Ju   +8 more
wiley   +1 more source

The prognostic value of pulmonary artery compliance in cardiogenic shock.

, 2019
The aim of this study was to evaluate the pathophysiological role and the prognostic significance of pulmonary artery compliance (C PA ), a measure of right ventricular pulsatile afterload, in cardiogenic shock. We retrospectively included 91 consecutive
Liaudet, L., Yerly, P., Zorzi, M.F., Cancelli, E., Rusca, M., Kirsch, M.   +5 more
core   +1 more source

Toward Nano‐Nutritional Medicine: A Remotely Activated Trans‐Vaccenic Acid‐Based Lipid Nanoparticles for Enhancing Immune Checkpoint Blockade Therapy

Advanced Science, EarlyView.
Eutectic mixtures from trans‐vaccenic acid (TVA) and stearic acid, which served as phase‐change material to encapsulate IR780, forming NIR‐responsive nanoparticles. IR780@TVA LNPs induce photothermal therapy and initiate adaptive anti‐tumor immunity.
Kang Liu, Yunlong Li, Hanmeng Liu, Peng Zhang, Mingjing Wang, Quanwei Sun, Wenshuo Yang, Zhengwei Song, Song Tan, Ye Yang, Peng She, Dengke Yin, Wei Shen   +12 more
wiley   +1 more source

Prevalence and Clinical Characteristics of Heterozygous RNF213 p.Arg4810Lys Variant Carriers Diagnosed With Chronic Thromboembolic Pulmonary Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Ring finger protein 213 (RNF213) p.Arg4810Lys is a susceptibility gene for moyamoya disease, peripheral pulmonary artery stenosis (PPS), and other vascular diseases and thrombosis. We investigated the prevalence and clinical characteristics of
Takatoyo Kiko, Ryotaro Asano, Tomohiko Ishibashi, Hiroyuki Endo, Naruhiro Nishi, Hiroya Hayashi, Jin Ueda, Tatsuo Aoki, Akihiro Tsuji, Yoshikazu Nakaoka, Takeshi Ogo   +10 more
doaj   +1 more source

Versican accumulates in vascular lesions in pulmonary arterial hypertension

, 2016
Pulmonary arterial hypertension (PAH) is a lethal condition for which there is no effective curative pharmacotherapy. PAH is characterized by vasoconstriction, wall thickening of pulmonary arteries, and increased vascular resistance.
Chan, Christina K., Inger Eriksson, Cao, Xiaofang, Ya‐Ting Chang, Tran-Lundmark, Karin,, Xiaofang Cao, Andersson-Sjöland, Annika, Kjellen, Lena,, Kjellén, Lena, Andersson-Sjoland, Annika,, Pamela Y. Johnson, Johansson, Staffan,, Gunilla Westergren‐Thorsson, Johnson, Pamela Y., Ulf Hedin, Karin Tran‐Lundmark, Cao, Xiaofang,, Wight, Thomas N., Westergren-Thorsson, Gunilla, Westöö, Christian, Tran-Lundmark, Karin, Johansson, Staffan, Lena Kjellén, Christian Westöö, Eriksson, Inger,, Annika Andersson‐Sjöland, Christina K. Chan, Thomas N. Wight, Hedin, Ulf,, Wight, Thomas N.,, Christian Norvik, Chang, Ya-Ting,, Chan, Christina K.,, Johnson, Pamela Y.,, Norvik, Christian, Hedin, Ulf, Chang, Ya Ting, Westoo, Christian,, Norvik, Christian,, Westergren-Thorsson, Gunilla,, Staffan Johansson, Eriksson, Inger   +41 more
core   +1 more source