Results 121 to 130 of about 1,251,660 (305)

Phase I clinical trial of cell therapy in patients with advanced chronic obstructive pulmonary disease: follow-up of up to 3 years

Revista Brasileira de Hematologia e Hemoterapia, 2013
BACKGROUND Chronic obstructive pulmonary disease is a major inflammatory disease of the airways and an enormous therapeutic challenge. Within the spectrum of chronic obstructive pulmonary disease, pulmonary emphysema is characterized by the destruction ...
Talita Stessuk, Milton Artur Ruiz, Oswaldo Tadeu Greco, Aldemir Bilaqui, Maria Jose de Oliveira Ribeiro-Paes, Joao Tadeu Ribeiro-Paes   +5 more
doaj   +1 more source

Angiogenesis in Chronic Obstructive Pulmonary Disease

, 2012
Angiogenesis is a crucial component of lung pathophysiology, not only in cancer but also in other disorders, such as chronic obstructive pulmonary disease (COPD).
Gaetano Santulli, Alessandro Matarese
core  

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease [PDF]

, 2023
Barbara D. Summers, Kihwan Kim, Tyler M. Lu, Sean Houghton, Anjali Trivedi, Joselyn Rojas Quintero, Juan Cala-García, Tania Pannellini, Francesca Polverino, Raphaël Lis, Hasina Outtz Reed   +10 more
openalex   +1 more source

Emphysema and bronchiectasis in COPD patients with previous pulmonary tuberculosis: computed tomography features and clinical implications

, 2018
Jianmin Jin,1 Shuling Li,2 Wenling Yu,2 Xiaofang Liu,1 Yongchang Sun1,3 1Department of Respiratory and Critical Care Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, 2Department of Radiology, Beijing Tongren Hospital, Capital ...
Li S, Yu W, Liu XF, Jin J, Sun Y
core  

Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.

, 2019
Translational research is essential to develop strategies for the treatment of pulmonary arterial hypertension (PAH) using animal models which reproduce the severity, the progressive nature and resistance to treatment of human PAH, including ...
Chaudhary, Ketul R., Legchenko, Ekaterina, Stewart, Duncan J., Hansmann, Georg, Bogaard, Harm J., Sun, Xiao Qing   +5 more
core   +1 more source

The 2025 ATS/ERS update of the international multidisciplinary classification of the interstitial pneumonias: implications for the pathologist

Histopathology, EarlyView.
This review highlights changes relevant to pathologists in the updated multidisciplinary classification of interstitial pneumonias. Changes include expansion beyond idiopathic disease, subclassification as interstitial (fibrotic vs non‐fibrotic) and alveolar filling disorders, expansion to include additional patterns (e.g.
Andrew G Nicholson, Wendy A. Cooper, Aurelie Fabre, William Travis, Lida P. Hariri, Ayodeji Adegunsoye, Sara Piciucchi, Christopher J Ryerson   +7 more
wiley   +1 more source

Predicting clinical outcome with phenotypic clusters using quantitative CT fibrosis and emphysema features in patients with idiopathic pulmonary fibrosis.

PLoS ONE, 2019
BackgroundThe clinical course of IPF varies. This study sought to identify phenotyping with quantitative computed tomography (CT) fibrosis and emphysema features using a cluster analysis and to assess prognostic impact among identified clusters in ...
So Hyeon Bak, Hye Yun Park, Jin Hyun Nam, Ho Yun Lee, Jeong Hyun Lee, Insuk Sohn, Man Pyo Chung   +6 more
doaj   +1 more source

Atypical characteristics of COVID-19 infection on CT imaging with preexisting combined pulmonary fibrosis and emphysema: A case report

, 2022
Wei Zhang, Xiong Wei, Yonghui Li, Yong Chen   +3 more
openalex   +1 more source