Results 101 to 110 of about 113,232 (234)

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Age-related changes in the respiratory system [PDF]

, 1999
This article summarises the main structural and physiological changes which take place in the lung from young adulthood to senescence. An understanding of these changes helps the clinician to correctly interpret some results of radiology and pulmonary ...
Ebejer, Martin J., Lesauskaite, Vita
core  

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Phase I clinical trial of cell therapy in patients with advanced chronic obstructive pulmonary disease: follow-up of up to 3 years

Revista Brasileira de Hematologia e Hemoterapia, 2013
BACKGROUND Chronic obstructive pulmonary disease is a major inflammatory disease of the airways and an enormous therapeutic challenge. Within the spectrum of chronic obstructive pulmonary disease, pulmonary emphysema is characterized by the destruction ...
Talita Stessuk, Milton Artur Ruiz, Oswaldo Tadeu Greco, Aldemir Bilaqui, Maria Jose de Oliveira Ribeiro-Paes, Joao Tadeu Ribeiro-Paes   +5 more
doaj   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Interval identification of natural effects in the presence of outcome‐related unmeasured confounding

Scandinavian Journal of Statistics, EarlyView.
Abstract With reference to a binary outcome and a binary mediator, we derive identification bounds for natural effects under a reduced set of assumptions. Specifically, no assumptions about confounding are made that involve the outcome; we only assume no unobserved exposure‐mediator confounding as well as a pair of conditions termed Partially Constant ...
Marco Doretti, Elena Stanghellini
wiley   +1 more source

Predicting clinical outcome with phenotypic clusters using quantitative CT fibrosis and emphysema features in patients with idiopathic pulmonary fibrosis.

PLoS ONE, 2019
BackgroundThe clinical course of IPF varies. This study sought to identify phenotyping with quantitative computed tomography (CT) fibrosis and emphysema features using a cluster analysis and to assess prognostic impact among identified clusters in ...
So Hyeon Bak, Hye Yun Park, Jin Hyun Nam, Ho Yun Lee, Jeong Hyun Lee, Insuk Sohn, Man Pyo Chung   +6 more
doaj   +1 more source

Prognostic Value of Magnetic Resonance Imaging Defined Extent of Surgical Resection in Dogs With Intracranial Meningiomas

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Surgery is a common treatment for intracranial meningiomas in dogs, although the prognostic impact of the extent of resection (EOR) has not been systematically evaluated. This retrospective study identified prognostic factors associated with clinical outcomes in dogs that underwent surgery and early post‐operative magnetic resonance imaging ...
John H. Rossmeisl, Rell L. Parker, Richard L. Shinn, Josefa K. Garcia Mora, Thomas E. Cecere, Teresa Southard, John L. Robertson   +6 more
wiley   +1 more source

Classification of lung disease in HRCT scans using integral geometry measures and functional data analysis [PDF]

, 2010
A framework for classification of chronic lung disease from high-resolution CT scans is presented. We use a set of features which measure the local morphology and topology of the 3D voxels within the lung parenchyma and apply functional data classification
Bhalerao, Abhir, Parr, David, Thönnes, Elke   +2 more
core   +1 more source

Safety and feasibility of near‐infrared fluorescence imaging with inhaled indocyanine green to assess the pulmonary parenchyma in six normal dogs

Veterinary Surgery, EarlyView.
Abstract Objective To assess the safety and feasibility of near‐infrared fluorescence (NIRF) imaging with inhaled indocyanine green (ICG) to visualize normal pulmonary parenchyma in dogs, report clinically useful information regarding dosage and timing of administration, and to evaluate effects on pulmonary function and tissue histology.
Jourdan B. McPhetridge, Michelle L. Oblak, Jacob Levine, Alex Lynch, Robert A. Foster, Valery F. Scharf   +5 more
wiley   +1 more source