Results 81 to 90 of about 1,251,660 (305)

Alendronate inhalation ameliorates elastase-induced pulmonary emphysema in mice by induction of apoptosis of alveolar macrophages

Nature Communications, 2015
Alveolar macrophages play a crucial role in the pathogenesis of emphysema, for which there is currently no effective treatment. Bisphosphonates are widely used to treat osteoclast-mediated bone diseases.
Manabu Ueno, T. Maeno, S. Nishimura, Fusa Ogata, Hiroaki Masubuchi, Kenichiro Hara, Kouichi Yamaguchi, Fumiaki Aoki, T. Suga, R. Nagai, M. Kurabayashi   +10 more
semanticscholar   +1 more source

Combined pulmonary fibrosis and emphysema syndrome: a radiologic perspective

Monaldi Archives for Chest Disease, 2015
Chronic obstructive pulmonary disease (that includes emphysema) results in significant morbidity and mortality worldwide. Idiopathic pulmonary fibrosis (IPF) is also a chronic and progressive parenchymal lung disease with an average survival of less than
I.B. Oliva, F. Cortopassi, C.L. Rochester, A.N. Rubinowitz   +3 more
doaj   +1 more source

MRI of the lung (3/3)-current applications and future perspectives [PDF]

, 2011
BackgroundMRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women.MethodsProvided there is sufficient expertise, magnetic ...
M. Both, Molinari, F., Mirsadraee, S., E. J. R. Van Beek, Molinari, F, Both, M, Beer, M., Bauman, G, Wild, J., Mirsadraee, S, Biederer, J, Hintze, C, Jürgen Biederer, J. Wild, S. Mirsadraee, Puderbach, M, Biederer, Jürgen, Wild, J, Bauman, G., M. Beer, M. Puderbach, Van Beek, E J R, Beer, M, Hintze, C., Both, M., G. Bauman, C. Hintze, Van Beek, EJR, F. Molinari, Van Beek, E. J. R., Puderbach, M.   +30 more
core   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, EarlyView.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source

Pulmonary Arterial Pruning and Longitudinal Change in Percent Emphysema and Lung Function [PDF]

, 2021
Carrie L. Pistenmaa, Pietro Nardelli, Samuel Y. Ash, C.E. Come, Alejandro A. Díaz, Farbod N. Rahaghi, R. Graham Barr, Kendra A. Young, Gregory L. Kinney, J.P. Simmons, R. Chad Wade, J. Michael Wells, John E. Hokanson, George R. Washko, Raúl San Jośe Estépar, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Terri H. Beaty, Peter J. Castaldi, Michael H. Cho, Dawn L. DeMeo, Adel Boueiz, Marilyn G. Foreman, Auyon Ghosh, Lystra P. Hayden, Craig P. Hersh, Jacqueline B. Hetmanski, Brian D. Hobbs, John E. Hokanson, Wonji Kim, Nan M. Laird, Christoph Lange, Sharon M. Lutz, Merry‐Lynn McDonald, Dmitry Prokopenko, Matthew Moll, Jarrett D. Morrow, Dandi Qiao, Elizabeth A. Regan, Aabida Saferali, Phuwanat Sakornsakolpat, Edwin K. Silverman, Emily S. Wan, Jeong H. Yun, Juan Pablo Centeno, Jean‐Paul Charbonnier, Harvey O. Coxson, Craig J. Galbán, MeiLan K. Han, Eric A. Hoffman, Stephen M. Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, David A. Lynch, Pietro Nardelli, John D. Newell, Aleena Notary, Andrea Oh, Elizabeth A. Regan, James C. Ross, Raúl San Jośe Estépar, Joyce Schroeder, Jered Sieren, Berend C. Stoel, Juerg Tschirren, Edwin J.R. van Beek, Bramvan Ginneken, Eva M. van Rikxoort, Gonzalo Vegas Sanchez Ferrero, Lucas Veitel, George R. Washko, Carla G. Wilson, Robert T. Jensen, D. H. Everett, Jim Crooks, Katherine Pratte, Matthew Strand, Carla G. Wilson, John E. Hokanson, Erin Austin, Gregory L. Kinney, Sharon M. Lutz, Kendra A. Young, Surya P. Bhatt, Jessica Bon, Alejandro A. Díaz, MeiLan K. Han, Barry J. Make, Susan Murray, Elizabeth A. Regan, Xavier Soler, Carla G. Wilson, Russell P. Bowler, Katerina Kechris, Farnoush Banaei‐Kashani, Jeffrey L. Curtis   +99 more
openalex   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, EarlyView.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

Pulmonary Vascular Volume by Quantitative CT in Dyspneic Smokers with Minor Emphysema

COPD, 2023
Reduced lung diffusing capacity for carbon monoxide (DLCO) at rest and increased ventilation (⩒E)-carbon dioxide output (⩒CO2) during exercise are frequent findings in dyspneic smokers with largely preserved FEV1.
Amany F. Elbehairy, Sandra G. Vincent, Devin B. Phillips, Matthew D. James, Jenna Veugen, Grace Parraga, Denis E. O’Donnell, J. Alberto Neder   +7 more
doaj   +1 more source

Sargassum Lung Syndrome: Air Flow Obstruction and Bronchial Inflammation Are Observed After Prolonged Exposure to Sargassum Gas Emissions in the Eastern Caribbean

Environmental Toxicology, EarlyView.
ABSTRACT Sargassum inundation of Caribbean and American shorelines is a growing environmental hazard. Hydrogen sulfide (H2S) and ammonia (NH3) produced by decomposing Sargassum could be involved in airway obstruction and bronchial inflammation. The study was undertaken to evaluate the effects of exposure to H2S and NH3 gases emitted during Sargassum ...
Rishika Banydeen, Jonathan Florentin, Maxime Boutourlinsky, Remi Nguyen, Fatima Radouani, Moustapha Agossou, Gary Lutin, Thierry Lebrun, Remi Neviere, Dabor Resiere   +9 more
wiley   +1 more source

Distribution of emphysema in heavy smokers: Impact on pulmonary function

, 2010
SummaryPurposeTo investigate impact of distribution of computed tomography (CT) emphysema on severity of airflow limitation and gas exchange impairment in current and former heavy smokers participating in a lung cancer screening trial.Materials and ...
Gietema, HA, Schilham, A, Gietema, H.A., Zanen, Pieter, Prokop, M., Lammers, J.W., Klaveren, RJ, Zanen, P., Schilham, A., Lammers, Jan Willem J., Gietema, Hester A., Zanen, P, van Ginneken, B, van Klaveren, Rob J., Prokop, Mathias, Klaveren, R.J.J. van, Prokop, M, Schilham, Arnold, Ginneken, B. van, Lammers, JWJ, van Ginneken, Bram   +20 more
core   +1 more source

Quantitative CT analysis in patients with pulmonary emphysema: Do calculated differences between full inspiration and expiration correlate with lung function?

, 2022
S.1877-1886Purpose: The aim of this retrospective study was to evaluate correlations between parameters of quantitative computed tomography (QCT) analysis, especially the 15th percentile of lung attenuation (P15), and parameters of clinical tests in a ...
Hubner, R.H., Feldhaus, F.W., Song, L., Neumann, K., Song, W., Fahlenkamp, U.L., Jin, Z., Theilig, D.C., Hamm, B., Leppig, J.A., Doellinger, F., Lassen-Schmidt, B.C.   +11 more
core   +1 more source