Results 91 to 100 of about 72,126 (206)

Targeting Elastin‐Derived Peptides Reverses Alveolar Epithelial Dysfunction in Chronic Obstructive Pulmonary Disease

MedComm, Volume 7, Issue 8, August 2026.
In COPD, extracellular matrix and elastin degradation increase elastin‐derived peptides (EDPs), which are associated with TLR4/NF‐κB activation, DKK1 upregulation, reduced β‐catenin signaling, and impaired AT2‐to‐AT1 differentiation. Neutralization of EDPs by TB partially restores β‐catenin‐associated alveolar epithelial differentiation and attenuates ...
Huijuan Zhu, Yiling Zhao, Yingchao Qin, Wenfeng Huang, Jiarui Weng, Zihan Liu, Jiahong Kuang, Zibei Feng, Zhilian Ye, Peiji Zheng, Xiaolan Guo, Fei Cui, Bingjie Chen, Pixin Ran, Jianwei Dai   +14 more
wiley   +1 more source

Leveraging Administrative Health Data to Capture Rare Adverse Drug Reactions: Identifying Pediatric Patients With Trimethoprim‐Sulfamethoxazole Acute Respiratory Distress Syndrome

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Rare adverse drug reactions (ADRs) are underrecognized and underreported in the electronic medical record (EMR). These events often require clinical review, making systematic identification challenging. The study aim was to develop an approach to prioritize identification and validation of a rare ADR to trimethoprim‐sulfamethoxazole causing ...
Keith Feldman, Jenna O. Miller, Katherine Doane, Laura Loftis, James W. Antoon, Kevin J. Downes, Jennifer L. Goldman   +6 more
wiley   +1 more source

The Role of Polyphenols in Respiratory and Gut Health: From the Perspective of Gut‐Lung Axis

Phytotherapy Research, Volume 40, Issue 8, Page 5071-5089, August 2026.
ABSTRACT The gut‐lung axis constitutes a dynamic, multidirectional communication platform between the gastrointestinal and respiratory tracts. Its complexity arises from the integrated crosstalk among the microbiota, immune system, and redox homeostasis, collectively influencing disease susceptibility and progression.
Jian Kang, YongJun Du, Yanmei Hou, Liangliang Hao, Zhen Chen, Haoyang Xie, Chuantao Zhang, Lei Li   +7 more
wiley   +1 more source

Small Cell Lung Cancer Associated With Cystic Airspace: A Case Report and Literature Review

Respirology Case Reports, Volume 14, Issue 8, August 2026.
We report a rare case of small cell lung cancer (SCLC) associated with a cystic airspace. Chest CT revealed a solid tumour component arising from the wall of a pre‐existing lung cyst. This case highlights the clinical importance of recognising cystic airspaces as potential sites for aggressive malignancies like SCLC.
Hiroyuki Shimada, Yukihisa Inoue, Osamu Matsubara, Mio Yamamoto, Shohei Yamashita, Tetsu Hara, Kazuki Yamanaka, Yasuto Jinn   +7 more
wiley   +1 more source

Association of incidental emphysema with annual lung function decline and future development of airflow limitation

International Journal of COPD, 2016
Hyeon-Kyoung Koo,1 Kwang Nam Jin,2 Deog Kyeom Kim,3 Hee Soon Chung,3 Chang-Hoon Lee3,4 1Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, College of Medicine, Ilsan Paik Hospital, Inje University, Goyang-si, Gyeonggi-Do,
Koo HK, Jin KN, Kim DK, Chung HS, Lee CH
doaj  

Treatable Traits‐Oriented Management in Pre‐COPD With Severe Obstructive Sleep Apnea: A Case Report of Symptomatic and Spirometric Improvement After Integrated Therapy

Respirology Case Reports, Volume 14, Issue 8, August 2026.
This case illustrates a multifactorial treatable traits‐oriented approach in pre‐COPD complicated by severe obstructive sleep apnea. Inhaled triple therapy plus effective CPAP was associated with symptomatic and spirometric improvement over 12 weeks, although causality cannot be inferred from a single case.
Norifumi Kudeken
wiley   +1 more source

Lung transplantation for COPD/pulmonary emphysema. [PDF]

Eur Respir Rev, 2023
Verleden GM, Gottlieb J.
europepmc   +1 more source

Bronchoscopic Localization of a Post‐Surgical Persistent Air Leak Facilitating Successful Treatment With a Hybrid Imaging‐Guided Percutaneous Sealing of Fistula and Autologous Blood Patch Technique

Respirology Case Reports, Volume 14, Issue 8, August 2026.
In this case of a complex post‐surgical PAL after radical thymectomy, lobectomy and pleurectomy, we describe how sequential bronchoscopic balloon catheter occlusion with the aid of a digital chest drain allowed physiological localization of an air leak predominantly originating from the LB6 lateral subsegment.
Ivory Ching Yee Yeo, Carrie Kah‐Lai Leong, Eugene MingJin Gan   +2 more
wiley   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Meta‐Analysis: Redefining Liver Disease Risk in Heterozygous Alpha‐1 Antitrypsin Deficiency

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 4, Page 430-440, August 2026.
SERPINA1 MZ/SZ genotypes is a common but under‐recognised liver risk state. Despite modest shifts in liver function tests, it is associated with approximately doubled odds of fibrosis, cirrhosis, and liver transplantation, supporting its inclusion in chronic liver disease risk assessment.
Adam M. Syanda, Dimitra Georgantaki, Riona T. T. Linn, Amara Agbai, Hassan Tahir, Manako Sakai, Richard Thompson, Mariam Molokhia, S. Tamir Rashid   +8 more
wiley   +1 more source