Results 61 to 70 of about 72,126 (206)

A Painful Purpuric Rash in a Febrile Smoker

JEADV Clinical Practice, EarlyView.
Eugerta Dilka, Ina Sotiri, Irda Rrugeja, Monika Fida   +3 more
wiley   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

A case report of subconjunctival emphysema as a rare complication of pulmonary resections

Journal of Minimal Access Surgery
Lung volume reduction surgery (LVRS) is performed to the selected patients with lung emphysema who have higher residual volume, restricted pulmonary functions and limited diaphragmatic movement. Post-operative prolonged air leak is not uncommon following
Ismail Sarbay, Akif Turna
doaj   +1 more source

Frailty and Fitness in Older Adults With Acute Myeloid Leukemia: From Chronological Age to Multiparametric Assessment

European Journal of Haematology, EarlyView.
ABSTRACT Acute Myeloid Leukemia predominantly affects older adults, who often present with comorbidities, functional impairment, and frailty, limiting eligibility for intensive chemotherapy or allogeneic transplantation. Historically, treatment options were restricted to hypomethylating agents, low‐dose cytarabine, hydroxyurea, or supportive care, with
Antonella Bruzzese, Enrica Antonia Martino, Santino Caserta, Maria Eugenia Alvaro, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Fortunato Morabito, Ernesto Vigna, Massimo Gentile   +11 more
wiley   +1 more source

Combined pulmonary fibrosis and emphysema: a narrative review

Frontiers in Medicine
Combined pulmonary fibrosis and emphysema (CPFE) is defined as a clinical-radiological-physiological syndrome characterized by upper-lobe emphysema and fibrosis predominantly in the lower lobes.
Wenjing Zeng, Binmiao Liang, Xuemei Ou
doaj   +1 more source

Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD

Respiratory Research, 2019
Background The mechanisms underlying airflow obstruction in COPD cannot be distinguished by standard spirometry. We ascertain whether mathematical modeling of airway biomechanical properties, as assessed from spirometry, could provide estimates of ...
Mariaelena Occhipinti, Matteo Paoletti, Brian J. Bartholmai, Srinivasan Rajagopalan, Ronald A. Karwoski, Cosimo Nardi, Riccardo Inchingolo, Anna R. Larici, Gianna Camiciottoli, Federico Lavorini, Stefano Colagrande, Vito Brusasco, Massimo Pistolesi   +12 more
doaj   +1 more source

Periodontitis and Chronic Conditions in Older Adults: A Scoping Review and Evidence Map of Systematic Reviews

Gerodontology, EarlyView.
ABSTRACT Background Periodontitis is a prevalent chronic inflammatory condition that frequently co‐occurs with systemic chronic diseases. Although older adults experience a high burden of both periodontitis and chronic conditions, the extent to which age‐specific evidence has been synthesised remains unclear.
Manisha Tamrakar, Najith Amarasena, Kym Michelle McCormick, Liana Luzzi, Gloria Mejia   +4 more
wiley   +1 more source

Idiopathic Pulmonary Fibrosis update, comparing the Australasian Interstitial Lung Disease Registry to the Australian Idiopathic Pulmonary Fibrosis Registry

Internal Medicine Journal, EarlyView.
Abstract Background and aims Real‐world evaluation of clinical characteristics and treatment profile of patients with idiopathic pulmonary fibrosis (IPF) is needed to establish areas for improvement according to evidence‐based recommendations. This study evaluated the clinical characteristics and treatment profile of patients with IPF from the ...
Michelle Chee, Yet Hong Khor, Dan Jackson, Wendy Cooper, Jason D’Costa, Sally de Boer, Adrienne Edwards, Samantha Ellis, Eli Gabbay, Henry Gallagher, Ian Glaspole, Nicole Goh, Christopher Grainge, Peter Hopkins, Gregory Keir, Benjamin Kwan, John Mackintosh, Yuben Moodley, Irene Moore, Vidya Navaratnam, Chong Ong, Paul Reynolds, Karen Royals, Alan Teoh, Lauren Troy, Elizabeth Veitch, Margaret Wilsher, Jeremy Wrobel, Chris Zappala, Tamera Corte, Francis Thien, on behalf of the AILDR Steering Committee   +31 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source