Results 41 to 50 of about 797,268 (256)

Impact of emphysema heterogeneity on pulmonary function. [PDF]

PLoS ONE, 2014
To investigate the association between emphysema heterogeneity in spatial distribution, pulmonary function and disease severity.We ascertained a dataset of anonymized Computed Tomography (CT) examinations acquired on 565 participants in a COPD study ...
Jieyang Ju, Ruosha Li, Suicheng Gu, Joseph K Leader, Xiaohua Wang, Yahong Chen, Bin Zheng, Shandong Wu, David Gur, Frank Sciurba, Jiantao Pu   +10 more
doaj   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Chronic Pulmonary Emphysema

Postgraduate Medicine, 1956
Patients with chronic pulmonary emphysema were analyzed on clinical and morphological standpoints. Pulmonary function tests and selective alveolobronchography were used for this study. Significant differences in two types of clinical features of chronic pulmonary emphysema were demonstrated on one aspect, and remarkable overlapping of alveolar and ...
B, HYDE, L, HYDE
openaire   +6 more sources

Combined Pulmonary Fibrosis and Emphysema: Pulmonary Function Testing and a Pathophysiology Perspective

Medicina, 2019
Combined pulmonary fibrosis and emphysema (CPFE) has been increasingly recognized over the past 10−15 years as a clinical entity characterized by rather severe imaging and gas exchange abnormalities, but often only mild impairment in spirometric ...
Diana E. Amariei, Neal Dodia, Janaki Deepak, Stella E. Hines, Jeffrey R. Galvin, Sergei P. Atamas, Nevins W. Todd   +6 more
doaj   +1 more source

Combined Pulmonary Fibrosis Emphysema: Role of Cigarette Smoking and Pulmonary Hypertension in a Rural Cohort

, 2021
Rahul Sangani,1 Andrew Ghio,2 Stacey Culp,3 Zalak Patel,4 Sunil Sharma1 1Section of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, West Virginia University, Morgantown, WV, USA; 2Human Studies Facility, US Environmental Protection ...
Culp S, Sharma S, Sangani R, Ghio A, Patel Z   +4 more
core  

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Effects of pirbuterol and sodium nitroprusside on pulmonary haemodynamics in hypoxic cor pulmonale [PDF]

, 1983
The acute haemodynamic effects of oral pirbuterol (a beta-agonist) were contrasted with those of sodium nitroprusside, a vasodilator, in six patients with hypoxic chronic bronchitis and emphysema.
Wathen, C G, Macnee, William, Flenley, DC, Hannan, W J, Muir, A.L   +4 more
core  

Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration

Molecules, 2022
Pulmonary emphysema is a fatal lung disease caused by the progressive thinning, enlargement and destruction of alveoli that is closely related to inflammation and oxidative stress.
Jianqing Peng, Zimin Cai, Qin Wang, Jia Zhou, Jinzhuan Xu, Di Pan, Tingting Chen, Guangqiong Zhang, Ling Tao, Yi Chen, Xiangchun Shen   +10 more
doaj   +1 more source

Targeting Kynurenine Synthesis Attenuated Cigarette Smoke‐Induced COPD‐Like Lung Injury Driven by TALDO1‐Mediated Metabolic Reprogramming

Advanced Science, EarlyView.
Cigarette smoke induces airway epithelial TALDO1 upregulation and L‐kynurenine accumulation, driving mitochondrial injury with elevated mtROS, reduced Δψm, ATP, and OCR. This links to lung inflammation, alveolar destruction, and lung function damage, all attenuated by Epacadostat or Taldo1 reduction.
Wenjing Wang, Mindan Wu, Yuanlan Yang, Zemin Chen, Jiawei Yan, Xuan Jin, Yachao Cui, Feng Zhang, Haiqing Li, Wensheng Chen, Yumin Zhou, Leqing Zhu, Wei Tu, Pixin Ran   +13 more
wiley   +1 more source

Imaging of pulmonary emphysema: A pictorial review

International Journal of COPD, 2008
Masashi Takahashi1, Junya Fukuoka2, Norihisa Nitta1, Ryutaro Takazakura1, Yukihiro Nagatani1, Yoko Murakami1, Hideji Otani1, Kiyoshi Murata11Department of Radiology, Shiga University of Medical Science, Shiga, Japan; 2Laboratory of Pathology, Toyama ...
Masashi Takahashi, Junya Fukuoka, Norihisa Nitta, Ryutaro Takazakura, Yukihiro Nagatani, et al   +5 more
doaj