Results 31 to 40 of about 797,268 (256)

In Vivo Electroporation-Mediated, Intrahepatic Alpha1 Antitrypsin Gene Transfer Reduces Pulmonary Emphysema in Pallid Mice

Pharmaceutics, 2020
Rationale: Mutation in the alpha1 antitrypsin (AAT) gene leads to low circulating levels of AAT, which is associated with several disease processes including pulmonary emphysema. The standard of care relies on substitution with plasma-purified AAT.
Marco A. Sutter, Tiziana P. Cremona, Izabela Nita, Eleonora Cavarra, Giuseppe Lungarella, Eli C. Lewis, Johannes C. Schittny, Thomas Geiser, Amiq Gazdhar   +8 more
doaj   +1 more source

Combined pulmonary fibrosis and emphysema syndrome: a radiologic perspective

Monaldi Archives for Chest Disease, 2015
Chronic obstructive pulmonary disease (that includes emphysema) results in significant morbidity and mortality worldwide. Idiopathic pulmonary fibrosis (IPF) is also a chronic and progressive parenchymal lung disease with an average survival of less than
I.B. Oliva, F. Cortopassi, C.L. Rochester, A.N. Rubinowitz   +3 more
doaj   +1 more source

Cardiovascular function in pulmonary emphysema [PDF]

, 2013
Chronic obstructive pulmonary disease (COPD) and chronic cardiovascular disease, such as coronary artery disease, congestive heart failure, and cardiac arrhythmias, have a strong influence on each other, and systemic inflammation has been considered as ...
Visca, Dina, CHETTA, Alfredo Antonio, Chetta, Alfredo, Aiello, Marina   +3 more
core   +1 more source

Pulmonary interstitial emphysema presenting in a woman on the intensive care unit: case report and review of literature

Journal of Medical Case Reports, 2011
Introduction Pulmonary interstitial emphysema is a life-threatening form of ventilator-induced lung injury. We present one of the few reported adult cases of pulmonary interstitial emphysema in a woman with respiratory failure admitted to our intensive ...
Jovaisa Tomas, Sherren Peter B
doaj   +1 more source

Persistent diffuse pulmonary interstitial emphysema mimicking pulmonary emphysema [PDF]

BMJ Case Reports, 2007
A 69-year-old male non-smoker with a history of atopic asthma presented with symptoms suggestive of chronic obstructive pulmonary disease and this appeared to be corroborated by lung function testing and a chest radiograph. However, a chest CT showed no evidence of pulmonary emphysema and instead demonstrated free air along the bronchovascular sheaths ...
Y, Demura, T, Ishizaki, M, Nakanishi, S, Ameshima, H, Itoh   +4 more
openaire   +6 more sources

Distinct responses to hypoxia in subpopulations of distal pulmonary artery cells contribute to pulmonary vascular remodeling in emphysema [PDF]

, 2012
We have shown previously that hypoxia inhibits the growth of distal human pulmonary artery smooth muscle cells (PASMC) isolated under standard normoxic conditions (PASMCnorm).
N. W. Morrell, Vaughan, P, Sobolewski, A, Howard, LS, Foster, ML, Howard, L. S., Morrell, NW, L. S. Howard, Chilvers, E. R., Chilvers, ER, A. Crosby, E. R. Chilvers, Crosby, A., Vaughan, P., P. Vaughan, Sobolewski, A., Southwood, M., A. Sobolewski, Foster, M. L., Southwood, M, Morrell, N. W., M. L. Foster, M. Southwood, Crosby, A   +23 more
core   +1 more source

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

Signal Transduction and Targeted Therapy, 2023
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.
Xia Xu, Tao Yu, Lingling Dong, Rainer Glauben, Siyuan Wu, Ronghua Huang, Shiwei Qumu, Chenli Chang, Jing Guo, Lin Pan, Ting Yang, Xin Lin, Ke Huang, Zhihua Chen, Chen Wang   +14 more
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

The impact of emphysema in pulmonary fibrosis [PDF]

European Respiratory Review, 2013
Several groups have described a syndrome in which idiopathic pulmonary fibrosis (IPF) coexists with pulmonary emphysema. This comes as no surprise since both diseases are associated with a history of exposure to cigarette smoke.
Vincent Cottin
doaj   +1 more source

Microfluidic Gratings for X‐Ray Phase Contrast Imaging

Advanced Science, EarlyView.
This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...
Alessandro Rossi, Antonio Ferraro, Francesco Coccimiglio, Tiziana Ritacco, Alberto Astolfo, Michele Giocondo, Vincenzo Formoso, Raffaele Giuseppe Agostino, Francesco Iacoviello, Ioannis Papakonstantinou, Alessandro Olivo   +10 more
wiley   +1 more source