Results 31 to 40 of about 1,251,660 (305)

In Vivo Electroporation-Mediated, Intrahepatic Alpha1 Antitrypsin Gene Transfer Reduces Pulmonary Emphysema in Pallid Mice

Pharmaceutics, 2020
Rationale: Mutation in the alpha1 antitrypsin (AAT) gene leads to low circulating levels of AAT, which is associated with several disease processes including pulmonary emphysema. The standard of care relies on substitution with plasma-purified AAT.
Marco A. Sutter, Tiziana P. Cremona, Izabela Nita, Eleonora Cavarra, Giuseppe Lungarella, Eli C. Lewis, Johannes C. Schittny, Thomas Geiser, Amiq Gazdhar   +8 more
doaj   +1 more source

Localized Pulmonary Interstitial Emphysema Which Occurred After Non-invasive Mechanical Ventilatory Support

, 2020
Pulmonary interstitial emphysema is a rare condition characterized by collection of air in the pulmonary interstitial tissue outside normal air passages as a result of injury to the alveoli and small airways, and accumulation of air within the ...
Hakan Ildır, Sevgi Pekcan, Abdullah Yazar, Esra Türe, Fatih Akın   +4 more
core   +1 more source

Binding of pulmonary surfactant proteins to carbon nanotubes; potential for damage to lung immune defense mechanisms [PDF]

, 2007
Potential pulmonary toxicity of carbon nanotubes is a research area that has received considerable attention. Surfactant proteins A and D (SP-A and SP-D) are collectin proteins that are secreted by airway epithelial cells in the lung.
Vlandas, A, Flahaut, E, Green, MLH, Vénien-Bryan, Catherine, Townsend, Paul, Green, Malcolm L. H., Flahaut, Emmanuel, Salvador-Morales, C, Sim, Robert B., Townsend, P, Salvador-Morales, Carolina, Venien-Bryan, C, Sim, RB, Vlandas, Alexis   +13 more
core   +1 more source

Improvement of pulmonary arterial compliance by pulmonary vasodilator in pulmonary hypertension from combined pulmonary fibrosis and emphysema

Respiratory Medicine Case Reports, 2019
Combined pulmonary fibrosis and emphysema (CPFE) is a common but under-recognized syndrome characterized with distinct profiles of both pulmonary fibrosis and emphysema.
Kei Kusaka, Yoshiteru Morio, Yuya Kimura, Keita Takeda, Masahiro Kawashima, Kimihiko Masuda, Hirotoshi Matsui   +6 more
doaj   +1 more source

Elimination of p19ARF‐expressing cells protects against pulmonary emphysema in mice

Aging Cell, 2018
Senescent cells accumulate in tissues during aging and are considered to underlie several aging‐associated phenotypes and diseases. We recently reported that the elimination of p19ARF‐expressing senescent cells from lung tissue restored tissue function ...
R. Mikawa, Yohei Suzuki, Hario Baskoro, Kazuki Kanayama, K. Sugimoto, Tadashi Sato, M. Sugimoto   +6 more
semanticscholar   +1 more source

Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation

Respiratory Research, 2017
Background Exacerbations in COPD are often accompanied by pulmonary and systemic inflammation, and associated with increased susceptibility to and prevalence of weight loss and muscle wasting.
Judith J. M. Ceelen, Annemie M. W. J. Schols, Stefan J. van Hoof, Chiel C. de Theije, Frank Verhaegen, Ramon C. J. Langen   +5 more
doaj   +1 more source

Effect of combined pulmonary fibrosis and emphysema on patients with connective tissue diseases and systemic sclerosis: a systematic review and meta-analysis

Arthritis Research & Therapy, 2021
Background This study aimed to analyze the literature systematically to determine the clinical characteristics and prognosis of patients with connective tissue disease (CTD) with combined pulmonary fibrosis and emphysema (CPFE) compared to those of ...
Bon San Koo, Kyu Yong Park, Hyun Jung Lee, Hyun Jung Kim, Hyeong Sik Ahn, Shin-Young Yim, Jae-Bum Jun   +6 more
doaj   +1 more source

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]

, 2011
Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Wu, Shaoping, Jae-Woong Hwang, Sundar, Isaac K, Sun, Jun, Isaac K. Sundar, Hwang, Jae-woong, Rahman, Irfan, Shaoping Wu, Irfan Rahman, Jun Sun   +9 more
core   +1 more source

A Low Peripheral Blood CD4/CD8 Ratio Is Associated with Pulmonary Emphysema in HIV

PLoS ONE, 2017
Objectives The prevalence of emphysema is higher among HIV-infected (HIV+) individuals compared to HIV-uninfected persons. While greater tobacco use contributes, HIV-related effects on immunity likely confer additional risk.
Matthew Triplette, E. Attia, Kathleen M. Akgün, G. S. Soo Hoo, M. Freiberg, A. Butt, C. Wongtrakool, M. Goetz, Sheldon T. Brown, C. Graber, Laurence Huang, K. Crothers   +11 more
semanticscholar   +1 more source

Genetic polymorphism in matrix metalloproteinase-9 and transforming growth factor-β1 and susceptibility to combined pulmonary fibrosis and emphysema in a Chinese population

Kaohsiung Journal of Medical Sciences, 2017
In this study, we aimed to explore the association of genetic polymorphism in matrix metalloproteinase-9 (MMP-9) and transforming growth factor-β1 (TGF-β1) and the susceptibility to combined pulmonary fibrosis and emphysema (CPFE).
Ling Xu, Wei Bian, Xiao-Hua Gu, Ce Shen
doaj   +1 more source